CN1102527A - 末梢血管舒张剂 - Google Patents

末梢血管舒张剂 Download PDF

Info

Publication number
CN1102527A
CN1102527A CN94190064A CN94190064A CN1102527A CN 1102527 A CN1102527 A CN 1102527A CN 94190064 A CN94190064 A CN 94190064A CN 94190064 A CN94190064 A CN 94190064A CN 1102527 A CN1102527 A CN 1102527A
Authority
CN
China
Prior art keywords
lower alkyl
quinolone
hydrogen atom
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94190064A
Other languages
English (en)
Chinese (zh)
Inventor
藤冈孝文
寺本修二
田中理纪
清水洋
田房不二男
富永道明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of CN1102527A publication Critical patent/CN1102527A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN94190064A 1993-02-16 1994-02-03 末梢血管舒张剂 Pending CN1102527A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26594/93 1993-02-16
JP5026594A JPH06239858A (ja) 1993-02-16 1993-02-16 末梢血管拡張剤

Publications (1)

Publication Number Publication Date
CN1102527A true CN1102527A (zh) 1995-05-10

Family

ID=12197866

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94190064A Pending CN1102527A (zh) 1993-02-16 1994-02-03 末梢血管舒张剂

Country Status (10)

Country Link
US (1) US5591751A (2)
EP (1) EP0636128A1 (2)
JP (1) JPH06239858A (2)
KR (1) KR950700900A (2)
CN (1) CN1102527A (2)
AU (1) AU666259B2 (2)
CA (1) CA2133207A1 (2)
PH (1) PH30979A (2)
TW (1) TW259789B (2)
WO (1) WO1994019339A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116143751A (zh) * 2022-07-15 2023-05-23 中国人民解放军军事科学院防化研究院 一种含苯乙烯吡啶的喹喔啉酮化合物及其制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06239858A (ja) * 1993-02-16 1994-08-30 Otsuka Pharmaceut Co Ltd 末梢血管拡張剤
IL155163A0 (en) * 2000-10-02 2003-10-31 Janssen Pharmaceutica Nv Metabotropic glutamate receptor antagonists
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
EP1709012B1 (en) * 2003-12-05 2015-07-29 Janssen Pharmaceutica NV 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose)polymerase inhibitors
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7487406B2 (en) * 2005-11-29 2009-02-03 International Business Machines Corporation Systems, methods, and media for managing software defects
TW200803855A (en) * 2006-02-24 2008-01-16 Kalypsys Inc Quinolones useful as inducible nitric oxide synthase inhibitors
EP2445877B1 (en) * 2008-12-03 2014-07-23 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
US11377452B2 (en) 2017-01-16 2022-07-05 Drexel University Glutamate transporter activators and methods using same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5165770A (ja) * 1974-12-04 1976-06-07 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS5168574A (ja) * 1974-12-07 1976-06-14 Otsuka Pharma Co Ltd Karubosuchirirujudotaino seizoho
JPS51118771A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
JPS597707B2 (ja) * 1975-06-23 1984-02-20 オオツカセイヤク カブシキガイシヤ カルボスチリルユウドウタイノ セイゾウホウ
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS5283380A (en) * 1975-12-26 1977-07-12 Otsuka Pharmaceut Co Ltd Synthesis of thiocarbostyril derivatives
JPS52118474A (en) * 1976-03-31 1977-10-04 Otsuka Pharmaceut Co Ltd Alpha-substituted aminoalkanyol-3,4-dihydrocarbostyril derivatives and method of preparing the same
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
JPS57171974A (en) * 1981-04-15 1982-10-22 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
JPS57154129A (en) * 1981-03-16 1982-09-22 Otsuka Pharmaceut Co Ltd Cardiotonic drug
JPS5929668A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
US4886809A (en) * 1986-07-31 1989-12-12 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof
US5405602A (en) * 1989-01-31 1995-04-11 Simmons; Paul L. Nonaqueous cold sterilant
EP0382185B1 (en) * 1989-02-10 1994-06-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JPH06239858A (ja) * 1993-02-16 1994-08-30 Otsuka Pharmaceut Co Ltd 末梢血管拡張剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116143751A (zh) * 2022-07-15 2023-05-23 中国人民解放军军事科学院防化研究院 一种含苯乙烯吡啶的喹喔啉酮化合物及其制备方法
CN116143751B (zh) * 2022-07-15 2025-07-15 中国人民解放军军事科学院防化研究院 一种含苯乙烯吡啶的喹喔啉酮化合物及其制备方法

Also Published As

Publication number Publication date
US5591751A (en) 1997-01-07
KR950700900A (ko) 1995-02-20
JPH06239858A (ja) 1994-08-30
EP0636128A1 (en) 1995-02-01
PH30979A (en) 1997-12-23
WO1994019339A1 (en) 1994-09-01
AU666259B2 (en) 1996-02-01
TW259789B (2) 1995-10-11
CA2133207A1 (en) 1994-09-01
AU5978894A (en) 1994-09-14

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