CN112494652A - 用于治疗骨髓增生异常综合征的jak1抑制剂 - Google Patents

用于治疗骨髓增生异常综合征的jak1抑制剂 Download PDF

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Publication number: CN112494652A
Authority: CN; China
Prior art keywords: pyrimidin; pyrrolo; pyrazol; trifluoromethyl; acetonitrile
Prior art date: 2014-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN202010986614.7A

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English (en)

Chinese (zh)

Inventor

K·瓦迪

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Incyte Corp

Original Assignee

Incyte Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-28

Filing date

2015-02-27

Publication date

2021-03-16

2015-02-27 Application filed by Incyte Corp filed Critical Incyte Corp

2021-03-16 Publication of CN112494652A publication Critical patent/CN112494652A/zh

Status Pending legal-status Critical Current

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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CN202010986614.7A 2014-02-28 2015-02-27 用于治疗骨髓增生异常综合征的jak1抑制剂 Pending CN112494652A (zh)

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CN201580017178.XA Pending CN106456773A (zh)	2014-02-28	2015-02-27	用于治疗骨髓增生异常综合征的jak1抑制剂

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US (4)	US20150246046A1 (2)
EP (1)	EP3110409B1 (2)
JP (1)	JP6576941B2 (2)
KR (1)	KR20160136323A (2)
CN (2)	CN112494652A (2)
AU (1)	AU2015222913B2 (2)
CA (1)	CA2940659C (2)
CL (1)	CL2016002144A1 (2)
CR (1)	CR20160449A (2)
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DK (1)	DK3110409T3 (2)
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SG10201807952PA (en)	2018-10-30
BR112016019511A8 (pt)	2023-01-24
EP3110409B1 (en)	2018-08-15
US20210069193A1 (en)	2021-03-11
SMT201800551T1 (it)	2019-01-11
NZ724464A (en)	2021-01-29
RS57723B1 (sr)	2018-12-31
CY1120857T1 (el)	2019-12-11
IL247475A0 (en)	2016-11-30
HRP20181661T1 (hr)	2018-12-14
KR20160136323A (ko)	2016-11-29
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ZA201606610B (en)	2020-08-26
UA121857C2 (uk)	2020-08-10
DK3110409T3 (en)	2018-10-22
PT3110409T (pt)	2018-11-07
AU2015222913B2 (en)	2019-12-12
MY185392A (en)	2021-05-17
US20150246046A1 (en)	2015-09-03
JP6576941B2 (ja)	2019-09-18
CA2940659C (en)	2023-01-03
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US20190111058A1 (en)	2019-04-18
SG11201607083VA (en)	2016-09-29
IL247475B (en)	2020-05-31
US20220378791A1 (en)	2022-12-01
CA2940659A1 (en)	2015-09-03
JP2017506659A (ja)	2017-03-09
EP3110409A1 (en)	2017-01-04
HUE041456T2 (hu)	2019-05-28
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CN106456773A (zh)	2017-02-22
PL3110409T3 (pl)	2018-12-31
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