CN1154746C - 酶促合成手性胺的改进 - Google Patents

酶促合成手性胺的改进 Download PDF

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Publication number
CN1154746C
CN1154746C CNB99803651XA CN99803651A CN1154746C CN 1154746 C CN1154746 C CN 1154746C CN B99803651X A CNB99803651X A CN B99803651XA CN 99803651 A CN99803651 A CN 99803651A CN 1154746 C CN1154746 C CN 1154746C
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CN
China
Prior art keywords
aminopropane
amino
chiral
transaminase
amine
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Expired - Fee Related
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CNB99803651XA
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English (en)
Chinese (zh)
Other versions
CN1292828A (zh
Inventor
吴薇
͵�
M·B·巴蒂亚
C·M·刘易斯
��ǡķ
郎伟
王俐
G·W·马恰姆
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Celgro
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Celgro
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB99803651XA 1998-03-11 1999-03-10 酶促合成手性胺的改进 Expired - Fee Related CN1154746C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7752098P 1998-03-11 1998-03-11
US60/077,520 1998-03-11

Publications (2)

Publication Number Publication Date
CN1292828A CN1292828A (zh) 2001-04-25
CN1154746C true CN1154746C (zh) 2004-06-23

Family

ID=22138554

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99803651XA Expired - Fee Related CN1154746C (zh) 1998-03-11 1999-03-10 酶促合成手性胺的改进

Country Status (23)

Country Link
EP (1) EP1075534B8 (cs)
JP (1) JP2002505884A (cs)
KR (1) KR20010034561A (cs)
CN (1) CN1154746C (cs)
AT (1) ATE295424T1 (cs)
AU (1) AU753904B2 (cs)
BR (1) BR9908797A (cs)
CA (1) CA2322605A1 (cs)
CZ (1) CZ295882B6 (cs)
DE (1) DE69925267T2 (cs)
ES (1) ES2243051T3 (cs)
FI (1) FI20001805A7 (cs)
HU (1) HUP0101056A3 (cs)
MX (1) MXPA00008573A (cs)
NO (1) NO319671B1 (cs)
NZ (1) NZ506405A (cs)
PL (1) PL342882A1 (cs)
PT (1) PT1075534E (cs)
RU (1) RU2213142C2 (cs)
SK (1) SK284352B6 (cs)
TR (1) TR200002604T2 (cs)
UA (1) UA64784C2 (cs)
WO (1) WO1999046398A1 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1038953B1 (en) * 1999-03-19 2004-09-22 Sumitomo Chemical Company, Limited Stereoselective transaminase, gene encoding said protein and use thereof
JP2001190298A (ja) * 2000-01-13 2001-07-17 Kanegafuchi Chem Ind Co Ltd 光学活性ｎ−メチルアミノ酸の製造方法
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
DE102007042600A1 (de) 2007-09-07 2009-03-12 Evonik Degussa Gmbh Verfahren zur Herstellung von enantiomerenangereichten Aminen
HUE036104T2 (hu) 2009-01-08 2018-06-28 Codexis Inc Transzamináz polipeptidek
JP5707344B2 (ja) 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
CN102597226B (zh) 2009-06-22 2015-08-19 科德克希思公司 转氨酶反应
EP2862938A3 (en) * 2009-09-02 2015-07-15 Lonza AG A process for the identification and preparation of a (R)-specific omega-transaminase
DK2582799T3 (en) 2010-06-17 2018-02-12 Codexis Inc BIOCATALATORS AND PROCEDURES FOR THE SYNTHESIS OF (S) -3- (1-AMINOETHYL) -PHENOL
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2744908A4 (en) * 2011-08-16 2015-05-27 Embio Ltd ENZYMATIC SYNTHESIS OPTICALLY ACTIVE CHIRAL AMINE
CN104630170A (zh) * 2013-11-08 2015-05-20 中国科学院天津工业生物技术研究所 一种来源于里氏木霉的新(r)-转氨酶及其应用
CN114134126B (zh) * 2021-10-28 2023-12-05 浙江大学杭州国际科创中心 转氨酶及其突变体在制备(s)-1-甲氧基-2-丙胺中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
WO1997015682A1 (en) * 1995-10-23 1997-05-01 Kaneka Corporation Process for producing optically active amino compounds

Also Published As

Publication number Publication date
MXPA00008573A (es) 2003-07-14
NO20004036L (no) 2000-10-27
FI20001805L (fi) 2000-08-15
NZ506405A (en) 2003-08-29
TR200002604T2 (tr) 2000-11-21
NO319671B1 (no) 2005-09-05
SK13382000A3 (sk) 2001-05-10
ES2243051T3 (es) 2005-11-16
NO20004036D0 (no) 2000-08-11
EP1075534A1 (en) 2001-02-14
EP1075534B8 (en) 2005-07-06
DE69925267T2 (de) 2006-01-26
PL342882A1 (en) 2001-07-16
RU2213142C2 (ru) 2003-09-27
JP2002505884A (ja) 2002-02-26
CZ20003177A3 (cs) 2000-12-13
PT1075534E (pt) 2005-09-30
HUP0101056A2 (hu) 2001-07-30
ATE295424T1 (de) 2005-05-15
HK1035000A1 (en) 2001-11-09
AU2993899A (en) 1999-09-27
DE69925267D1 (de) 2005-06-16
EP1075534B1 (en) 2005-05-11
CN1292828A (zh) 2001-04-25
WO1999046398A1 (en) 1999-09-16
HUP0101056A3 (en) 2006-03-28
EP1075534A4 (en) 2003-07-09
SK284352B6 (sk) 2005-02-04
UA64784C2 (en) 2004-03-15
CA2322605A1 (en) 1999-09-16
KR20010034561A (ko) 2001-04-25
BR9908797A (pt) 2000-12-12
AU753904B2 (en) 2002-10-31
FI20001805A7 (fi) 2000-09-11
CZ295882B6 (cs) 2005-11-16

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