CN115583947A - 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 - Google Patents

作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 Download PDF

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Publication number
CN115583947A
CN115583947A CN202211065963.0A CN202211065963A CN115583947A CN 115583947 A CN115583947 A CN 115583947A CN 202211065963 A CN202211065963 A CN 202211065963A CN 115583947 A CN115583947 A CN 115583947A
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CN
China
Prior art keywords
pyrrolo
pyridin
oxo
enyl
methyl
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Pending
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CN202211065963.0A
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English (en)
Chinese (zh)
Inventor
B·K·阿尔布雷克特
S·F·贝隆
D·J·伯迪克
A·科特
T·克劳福德
L·A·戴金
M·C·休伊特
V·萧魏徐
Y·勒布朗
S·R·马格努森
C·G·纳斯维斯查克
F·A·罗梅罗
Y·唐
A·M·泰勒
S·王
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Genentech Inc
Constellation Pharmaceuticals Inc
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Genentech Inc
Constellation Pharmaceuticals Inc
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Application filed by Genentech Inc, Constellation Pharmaceuticals Inc filed Critical Genentech Inc
Publication of CN115583947A publication Critical patent/CN115583947A/zh
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202211065963.0A 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 Pending CN115583947A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462077703P 2014-11-10 2014-11-10
US62/077,703 2014-11-10
PCT/US2015/060003 WO2016077378A1 (en) 2014-11-10 2015-11-10 Substituted pyrrolopyrdines as inhibitors of bromodomain
CN201580072359.2A CN107207493B (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

Related Parent Applications (1)

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CN202211065963.0A Pending CN115583947A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN201580072359.2A Expired - Fee Related CN107207493B (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202310032629.3A Pending CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

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CN202310032629.3A Pending CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

Country Status (6)

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US (1) US10183009B2 (2)
EP (1) EP3218375B1 (2)
JP (1) JP6669744B2 (2)
CN (3) CN115583947A (2)
MA (1) MA40943A (2)
WO (1) WO2016077378A1 (2)

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WO2016077378A1 (en) 2016-05-19
CN107207493A (zh) 2017-09-26
MA40943A (fr) 2017-09-19
US20170340605A1 (en) 2017-11-30
JP2017533248A (ja) 2017-11-09
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CN116003409A (zh) 2023-04-25

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