CN1159183A - 作为抗癌和抗病毒剂的二-(2-卤代乙基)氨基苯基取代的偏端霉素衍生物 - Google Patents

作为抗癌和抗病毒剂的二-(2-卤代乙基)氨基苯基取代的偏端霉素衍生物 Download PDF

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Publication number
CN1159183A
CN1159183A CN96190784A CN96190784A CN1159183A CN 1159183 A CN1159183 A CN 1159183A CN 96190784 A CN96190784 A CN 96190784A CN 96190784 A CN96190784 A CN 96190784A CN 1159183 A CN1159183 A CN 1159183A
Authority
CN
China
Prior art keywords
methyl
pyrrole
formylamino
carboxamido
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96190784A
Other languages
English (en)
Chinese (zh)
Inventor
P·科兹
I·贝里亚
L·卡珀隆格
C·福兰泽蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CN1159183A publication Critical patent/CN1159183A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96190784A 1995-07-21 1996-06-19 作为抗癌和抗病毒剂的二-(2-卤代乙基)氨基苯基取代的偏端霉素衍生物 Pending CN1159183A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514993.6A GB9514993D0 (en) 1995-07-21 1995-07-21 Site specific phenyl nitrogen mustards
GB9514993.6 1995-07-21

Publications (1)

Publication Number Publication Date
CN1159183A true CN1159183A (zh) 1997-09-10

Family

ID=10778062

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96190784A Pending CN1159183A (zh) 1995-07-21 1996-06-19 作为抗癌和抗病毒剂的二-(2-卤代乙基)氨基苯基取代的偏端霉素衍生物

Country Status (18)

Country Link
EP (1) EP0787126A1 (fr)
JP (1) JPH10506410A (fr)
KR (1) KR970706251A (fr)
CN (1) CN1159183A (fr)
AR (1) AR003456A1 (fr)
AU (1) AU6357996A (fr)
BR (1) BR9606528A (fr)
CA (1) CA2199635A1 (fr)
EA (1) EA000033B1 (fr)
GB (1) GB9514993D0 (fr)
HU (1) HUP9702393A3 (fr)
IL (1) IL120342A0 (fr)
MX (1) MX9701949A (fr)
NO (1) NO971142D0 (fr)
PL (1) PL319352A1 (fr)
TW (1) TW367325B (fr)
WO (1) WO1997003957A1 (fr)
ZA (1) ZA965028B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968186A1 (fr) 1996-02-26 2000-01-05 California Institute Of Technology Polyamides ameliores pour assurer une liaison dans le sillon mineur de l'adn a double brins
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US5998140A (en) * 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9907414D0 (en) * 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
US20030236198A1 (en) 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
ATE425753T1 (de) 2002-08-02 2009-04-15 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
EP1562931A2 (fr) 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Composes biaryle anti-infectieux
JP2006509027A (ja) 2002-12-10 2006-03-16 オーシェント ファーマシューティカルズ コーポレーション （ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
EP2792355A1 (fr) 2013-04-17 2014-10-22 Albert-Ludwigs-Universität Freiburg Composés destinés à être utilisés comme inhibiteurs de bromodomaine
CN115414356A (zh) * 2022-09-27 2022-12-02 广西科技大学 一种茚并吡咯类衍生物在制备抗肿瘤药物组合物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
PL319352A1 (en) 1997-08-04
HUP9702393A2 (hu) 1998-04-28
NO971142L (no) 1997-03-12
JPH10506410A (ja) 1998-06-23
EA199700046A1 (ru) 1997-12-30
IL120342A0 (en) 1997-06-10
AU6357996A (en) 1997-02-18
ZA965028B (en) 1997-01-23
MX9701949A (es) 1997-06-28
CA2199635A1 (fr) 1997-02-06
TW367325B (en) 1999-08-21
BR9606528A (pt) 1997-12-23
WO1997003957A1 (fr) 1997-02-06
EA000033B1 (ru) 1998-02-26
GB9514993D0 (en) 1995-09-20
KR970706251A (ko) 1997-11-03
EP0787126A1 (fr) 1997-08-06
HUP9702393A3 (en) 1998-05-28
AR003456A1 (es) 1998-08-05
NO971142D0 (no) 1997-03-12

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication