CN1278260A - 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 - Google Patents

氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 Download PDF

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Publication number
CN1278260A
CN1278260A CN98810769A CN98810769A CN1278260A CN 1278260 A CN1278260 A CN 1278260A CN 98810769 A CN98810769 A CN 98810769A CN 98810769 A CN98810769 A CN 98810769A CN 1278260 A CN1278260 A CN 1278260A
Authority
CN
China
Prior art keywords
methyl
benzo
hexahydro
quinazinyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98810769A
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English (en)
Chinese (zh)
Inventor
P·梅耶
J－L·维达鲁克
T·伊姆伯特
M·马瑞恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of CN1278260A publication Critical patent/CN1278260A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN98810769A 1997-10-28 1998-10-26 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用 Pending CN1278260A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR97/13499 1997-10-28
FR9713499A FR2770215B1 (fr) 1997-10-28 1997-10-28 Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives

Publications (1)

Publication Number Publication Date
CN1278260A true CN1278260A (zh) 2000-12-27

Family

ID=9512729

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98810769A Pending CN1278260A (zh) 1997-10-28 1998-10-26 氨基甲基－苯并[α]喹嗪烷衍生物、其制备及其在治疗神经变性性疾病中的应用

Country Status (8)

Country Link
EP (1) EP1027350A1 (fr)
JP (1) JP2001521034A (fr)
CN (1) CN1278260A (fr)
AU (1) AU9751798A (fr)
BR (1) BR9813303A (fr)
CA (1) CA2307748A1 (fr)
FR (1) FR2770215B1 (fr)
WO (1) WO1999021856A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0016454D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Thienopyrrolidinones
JPWO2006054793A1 (ja) 2004-11-19 2008-06-05 財団法人新産業創造研究機構 ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP1855677B1 (fr) * 2005-08-06 2008-12-03 Cambridge Laboratories (Ireland) Limited 3,11b cis-dihydrotetrabenazine permettant de traiter la schizophrenie et d'autres psychoses
DK2012833T3 (en) * 2006-05-02 2015-01-19 Univ Pennsylvania RADIOACTIVALLY LABELED DIHYDROTETRABENAZINE DERIVATIVES AND USE THEREOF AS IMAGING AGENTS
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
FR2976287B1 (fr) * 2011-06-09 2013-07-05 Pf Medicament Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique
EP2758376A4 (fr) * 2011-09-19 2015-04-29 Vitas Pharma Res Private Ltd Composés hétérocycliques en tant qu'inhibiteurs de la biosynthèse d'acide gras pour des infections bactériennes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8416432D0 (en) * 1984-06-28 1984-08-01 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
JP2001521034A (ja) 2001-11-06
FR2770215B1 (fr) 2000-01-14
BR9813303A (pt) 2000-08-29
CA2307748A1 (fr) 1999-05-06
AU9751798A (en) 1999-05-17
FR2770215A1 (fr) 1999-04-30
EP1027350A1 (fr) 2000-08-16
WO1999021856A1 (fr) 1999-05-06

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication