CN1291233A - 来自肺炎链球菌之人类补体c3降解蛋白酶 - Google Patents

来自肺炎链球菌之人类补体c3降解蛋白酶 Download PDF

Info

Publication number
CN1291233A
CN1291233A CN98809460A CN98809460A CN1291233A CN 1291233 A CN1291233 A CN 1291233A CN 98809460 A CN98809460 A CN 98809460A CN 98809460 A CN98809460 A CN 98809460A CN 1291233 A CN1291233 A CN 1291233A
Authority
CN
China
Prior art keywords
protein
seq
nucleic acid
isolated
streptococcus pneumoniae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98809460A
Other languages
English (en)
Chinese (zh)
Inventor
马格列特K·贺斯泰特
大卫J·芬科尔
程希
布鲁斯A·葛林
爱美W·马西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
University of Minnesota System
Original Assignee
American Cyanamid Co
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co, University of Minnesota System filed Critical American Cyanamid Co
Publication of CN1291233A publication Critical patent/CN1291233A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN98809460A 1997-09-24 1998-09-24 来自肺炎链球菌之人类补体c3降解蛋白酶 Pending CN1291233A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5990797P 1997-09-24 1997-09-24
US60/059,907 1997-09-24

Publications (1)

Publication Number Publication Date
CN1291233A true CN1291233A (zh) 2001-04-11

Family

ID=22026061

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98809460A Pending CN1291233A (zh) 1997-09-24 1998-09-24 来自肺炎链球菌之人类补体c3降解蛋白酶

Country Status (8)

Country Link
EP (1) EP1017828A1 (fr)
JP (1) JP2001517449A (fr)
KR (1) KR20010024299A (fr)
CN (1) CN1291233A (fr)
AU (1) AU9510598A (fr)
BR (1) BR9812525A (fr)
CA (1) CA2305016A1 (fr)
WO (1) WO1999015675A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102731739A (zh) * 2012-07-05 2012-10-17 富阳经略化工技术有限公司 用作润滑油粘度指数改进剂的星形聚合物及其制备方法和应用

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
ATE348887T1 (de) 1996-10-31 2007-01-15 Human Genome Sciences Inc Streptococcus pneumoniae antigene und impfstoffe
US6676943B1 (en) 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
EP1783224A3 (fr) * 1998-07-27 2007-08-15 Sanofi Pasteur Limited Protéines de Streptococcus pneumoniae et molécules d'acide nucléique
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
EP1115875A1 (fr) * 1998-09-24 2001-07-18 Regents Of The University Of Minnesota Polypeptide de degradation du complement humain c3 de streptococcus pneumoniae
CA2355364C (fr) 1998-12-21 2014-03-18 Medimmune, Inc. Proteines de streptococcus pneumoniae et fragments immunogenes pour vaccins
EP1950302B1 (fr) * 1998-12-23 2012-12-05 ID Biomedical Corporation of Quebec Nouveaux antigènes de streptocoque
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
AU2005209689B2 (en) * 1998-12-23 2008-07-17 Id Biomedical Corporation Of Quebec Novel streptococcus antigens
PL205041B1 (pl) * 1998-12-23 2010-03-31 Id Biomedical Corp Izolowany polinukleotyd, wektor zawierający izolowany polinukleotyd, komórka gospodarza transfekowana lub transformowana za pomocą tego wektora, sposób wytwarzania polipeptydu kodowanego przez izolowany polinukleotyd, izolowany polipeptyd, chimeryczny polipeptyd, kompozycja do szczepionek zawierająca polipeptyd oraz jej zastosowanie w leczeniu lub zapobieganiu zakażeniu osobnika paciorkowcem
WO2001098334A2 (fr) * 2000-06-20 2001-12-27 Shire Biochem Inc. Antigenes de streptocoque
US7074415B2 (en) 2000-06-20 2006-07-11 Id Biomedical Corporation Streptococcus antigens
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
BR0116756A (pt) * 2000-12-28 2005-01-04 Wyeth Corp Proteìna protetora recombinante de streptococcus pneumoniae e uso da mesma
US7262024B2 (en) 2001-12-20 2007-08-28 Id Biomedical Corporation Streptococcus antigens
KR101126423B1 (ko) * 2005-10-21 2012-07-11 카탈리스트 바이오사이언시즈, 인코포레이티드 보체 활성화를 억제하는 변형된 프로테아제
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
JP5792920B2 (ja) 2005-12-22 2015-10-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
EA200901578A1 (ru) 2007-06-26 2010-08-30 Глаксосмитклайн Байолоджикалс С.А. Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
KR20110009157A (ko) 2008-04-16 2011-01-27 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
KR20140033127A (ko) 2011-05-17 2014-03-17 글락소스미스클라인 바이오로지칼즈 에스.에이. 스트렙토코쿠스 뉴모니애에 대한 백신
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
GB201711635D0 (en) 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE348887T1 (de) * 1996-10-31 2007-01-15 Human Genome Sciences Inc Streptococcus pneumoniae antigene und impfstoffe
EP0977872A1 (fr) * 1997-04-24 2000-02-09 Regents Of The University Of Minnesota PROTEINASE, ISSUE DE $i(STREPTOCOCCUS PNEUMONIAE) DEGRADANT LA PROTEINE C3 HUMAINE DU COMPLEMENT

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102731739A (zh) * 2012-07-05 2012-10-17 富阳经略化工技术有限公司 用作润滑油粘度指数改进剂的星形聚合物及其制备方法和应用
CN102731739B (zh) * 2012-07-05 2013-11-06 富阳经略化工技术有限公司 用作润滑油粘度指数改进剂的星形聚合物及其制备方法和应用

Also Published As

Publication number Publication date
JP2001517449A (ja) 2001-10-09
BR9812525A (pt) 2000-07-25
WO1999015675A1 (fr) 1999-04-01
CA2305016A1 (fr) 1999-04-01
KR20010024299A (ko) 2001-03-26
AU9510598A (en) 1999-04-12
EP1017828A1 (fr) 2000-07-12

Similar Documents

Publication Publication Date Title
CN1352691A (zh) 来自肺炎链球菌的人补体c3降解性多肽
AU9510598A (en) Human complement c3-degrading proteinase from (streptococcus pneumoniae)
JPH1169980A (ja) 新規ｄｎａ鎖リゾルーション
JP2000512487A (ja) 新規化合物
JP2001508650A (ja) 新規細菌ポリペプチドおよびポリヌクレオチド
CN1240001A (zh) 链球菌毒素c突变体及其使用方法
JPH05502370A (ja) 分子量３９ｋＤａの赤痢病原体抗原およびそれに対する遺伝子暗号付与
JPH10191987A (ja) 新規３−デヒドロキナ酸シンターゼ
US6676943B1 (en) Human complement C3-degrading protein from Streptococcus pneumoniae
JPH11103871A (ja) 新規化合物
CN1150324C (zh) 一种新的人溶菌酶基因、其编码的多肽及制备方法
JPH1189585A (ja) 新規Ｄｅｆ１
CN1224710C (zh) 一种新的人溶菌酶基因、其编码的多肽及制备方法
JP2002508171A (ja) 新規ａｂｃトランスポーター
AU740153B2 (en) Human complement C3-degrading proteinase from streptococcus pneumoniae
JPH11266880A (ja) 新規ｄｂｐＡ
CN1149290C (zh) 一种新的人溶菌酶基因、其编码的多肽及制备方法
MXPA00002932A (en) Human complement c3-degrading proteinase from streptococcus pneumoniae
JPH10313875A (ja) 新規化合物
JPH11127879A (ja) 新規ｇｉｄＡ１
JPH1175877A (ja) 新規化合物
JP2001516211A (ja) スタフィロコッカスの３−デヒドロキネートシンターゼ
JP2002506624A (ja) スタフィロコッカス・アウレウスｓｐｏ０ｊ２：ポリヌクレオチドおよび蛋白
AU2420800A (en) Human complement C3-degrading polypeptide from streptococus pneumoniae
JPH10229886A (ja) ｓｐｏ／ｒｅｌ

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication