CN1328452A - 苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途 - Google Patents

苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途 Download PDF

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Publication number
CN1328452A
CN1328452A CN99813826A CN99813826A CN1328452A CN 1328452 A CN1328452 A CN 1328452A CN 99813826 A CN99813826 A CN 99813826A CN 99813826 A CN99813826 A CN 99813826A CN 1328452 A CN1328452 A CN 1328452A
Authority
CN
China
Prior art keywords
het
methyl
hal
insulin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99813826A
Other languages
English (en)
Chinese (zh)
Inventor
R·格里克
M·鲍姆加斯
K·明克
D·梅桑格奥
L·多尔雷
M·克尔戈尔特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN1328452A publication Critical patent/CN1328452A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN99813826A 1998-11-26 1999-11-16 苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途 Pending CN1328452A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98122419.9 1998-11-26
EP98122419 1998-11-26

Publications (1)

Publication Number Publication Date
CN1328452A true CN1328452A (zh) 2001-12-26

Family

ID=8233036

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99813826A Pending CN1328452A (zh) 1998-11-26 1999-11-16 苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途

Country Status (14)

Country Link
EP (1) EP1131064A2 (id)
JP (1) JP2002530325A (id)
KR (1) KR20010080597A (id)
CN (1) CN1328452A (id)
AR (1) AR023064A1 (id)
AU (1) AU1553500A (id)
BR (1) BR9915667A (id)
CA (1) CA2352154A1 (id)
CZ (1) CZ20011785A3 (id)
HU (1) HUP0104418A2 (id)
ID (1) ID29523A (id)
NO (1) NO20012563L (id)
PL (1) PL348152A1 (id)
WO (1) WO2000030624A2 (id)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379410C (zh) * 2002-06-05 2008-04-09 株式会社医药分子设计研究所 糖尿病治疗药

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381841B2 (en) 2003-08-22 2008-06-03 Sanofi-Aventis Deutschland Gmbh Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE4437874A1 (de) * 1994-10-22 1996-04-25 Merck Patent Gmbh Alkyl-5-methylsulfonyl-benzoylguanidin-Derivate
DE19502644A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh 4-Amino-benzoylguanidin-Derivate
DE19502895A1 (de) * 1995-01-31 1996-08-01 Merck Patent Gmbh 4-Mercapto-benzoylguanidin-Derivate
DE19517848A1 (de) * 1995-05-16 1996-11-21 Merck Patent Gmbh Fluorhaltige Benzoylguanidine
DE19531138A1 (de) * 1995-08-24 1997-02-27 Merck Patent Gmbh Alkenyl-benzoylguanidin-Derivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100379410C (zh) * 2002-06-05 2008-04-09 株式会社医药分子设计研究所 糖尿病治疗药

Also Published As

Publication number Publication date
NO20012563D0 (no) 2001-05-25
CZ20011785A3 (cs) 2001-10-17
ID29523A (id) 2001-09-06
PL348152A1 (en) 2002-05-06
HUP0104418A2 (hu) 2002-04-29
EP1131064A2 (en) 2001-09-12
JP2002530325A (ja) 2002-09-17
AU1553500A (en) 2000-06-13
CA2352154A1 (en) 2000-06-02
BR9915667A (pt) 2001-08-14
KR20010080597A (ko) 2001-08-22
WO2000030624A3 (en) 2000-10-05
NO20012563L (no) 2001-05-25
AR023064A1 (es) 2002-09-04
WO2000030624A2 (en) 2000-06-02

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Legal Events

Date Code Title Description
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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication