CN1431903A - 含敏乐定的制剂 - Google Patents

含敏乐定的制剂 Download PDF

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CN1431903A
CN1431903A CN01810649A CN01810649A CN1431903A CN 1431903 A CN1431903 A CN 1431903A CN 01810649 A CN01810649 A CN 01810649A CN 01810649 A CN01810649 A CN 01810649A CN 1431903 A CN1431903 A CN 1431903A
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michloridine
antioxidant
root
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bark
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今村康二
落合留美
冈岛孝子
森冈进
堀江太郎
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Taisho Pharmaceutical Co Ltd
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Abstract

本发明提供了一种含敏乐定的组合物，该组合物可保持长时间不改变颜色。该组分含有一种抗氧化剂，例如二丁基羟基甲苯，丁基羟基苯甲醚或异抗坏血酸，其pH值为5.5～7.0。

Description

含敏乐定的制剂
技术领域
本发明涉及一种防止随时间而改变颜色的敏乐定组合物。
技术背景
敏乐定(minoxidil)是一种具有促进毛发生长作用的成分，可以将其作为一种体外毛发生长剂。
然而，当敏乐定以溶液状态长时间储存时会逐渐改变颜色，从而存在着其商品价值受损的潜在危险。本发明要解决的问题
本发明的目的是防止含敏乐定的组合物改变颜色。
本发明的公开
一般来说，为了将一种可能变色的组分并入一种液态制剂，在制剂中加入抗氧化剂(如二丁基羟基甲苯)可以改善制剂的抗变色性。然而，本发明人发现，如果是含敏乐定的液态制剂，若在其中加入抗氧化剂(如二丁基羟基甲苯)则不能防止制剂变色，甚至还增强其变色的程度。
为了解决这个问题，经过大量的研究发现，当将一种含敏乐定的液态组合物的pH值调至5.5～7.0时，上述缺点会得以克服，对这种液态制剂变色的保护作用会明显提高，从而实现了本发明的目的。
即，本发明涉及一种含敏乐定的组合物，该组合物包括抗氧化剂，以及其pH值为5.5～7.0。
进而，本发明涉及一种含敏乐定的组合物，该组合物包括二丁基羟基甲苯或丁基羟基苯甲醚，以及其pH值为5.5～7.0。
更进一步，本发明涉及一种防止含敏乐定的组分变色的方法，该方法是在这种组合物中加入抗氧化剂并将该组合物的pH值调至5.5～7.0。实现本发明的方式
本发明优选下列一组化合物中的一或二种作为抗氧化剂：二丁基羟基甲苯，丁基羟基苯甲醚，异抗坏血酸，乙二胺四乙酸二钠，柠檬酸异丙基酯，倍酸丙基酯，愈创木酸，α-硫甘油，二氯异氰尿酸钾，2，6-二-反式-丁基-4-甲基苯酚，大豆卵磷脂，巯基乙酸钠，硫羟苹果酸钠，抗坏血酸棕榈酸酯，2-巯基苯咪唑和氧化喹啉硫酸盐。此外，一种草本植物提取物也可作为抗氧化剂，优选的一、二种这类抗氧化剂包括下列草本植物的提取物：丁香，天竺葵，大黄，黄柏树皮，芍药根，幕天树皮，黄连的根茎，橘皮，蛇麻草，黄芩根，樟树皮，甘草，桔梗根，生姜，红花和日本当归根。这些草本植物的提取液可以用水或含2～4个碳原子的醇(例如乙醇，丙二醇，1，3-丁二醇或甘油)，或水与这种醇的混合物作为溶剂进行提取来制备。
该组分中这种抗氧化剂与敏乐定的比例，优选的范围为0.005∶1～0.5∶1(质量比)，更优选的范围为0.01∶1～0.5∶1(质量比)。因抗氧化剂的种类不同，若添加的抗氧化剂的量不足，即使pH值在5.5～7.0的范围之内，有时也会促使组合物变色。
本发明的组合物中，pH值降低会使防止变色的保护作用减弱，因此优选地应使pH值调至5.5或5.5以上，更优选的应使pH值调至5.7或5.7以上。
考虑到敏乐定的溶解性，优选地应使pH值调至7.0或7.0以下，更优选的应使pH值调至6.3或6.3以下。
可用常规的pH值调节剂调节本发明的组合物的pH值，例如用有机酸(如柠檬酸，苹果酸和乳酸)，或无机酸(如磷酸，盐酸和硫酸)。
本发明组合物中，若以整个组合物质量为1，则敏乐定的浓度范围，优选的为1％～10％，更优选的为3％～6％。
本发明的组合物中优选地可含一种多元醇为溶剂。
至于这类多元醇，优选的是丙二醇，二丙二醇，1，3-丁二醇，甘油，己二醇和聚乙二醇，更优选的是1，3-丁二醇。至于聚乙二醇，优选的是聚乙二醇200和聚乙二醇400。加入的多元醇的量与敏乐定的质量比，优选地为1∶1～50∶1。
本发明的组合物的制剂剂型可以是，但不特别限定于，各种洗剂、气雾剂和凝胶剂，这些剂型的产品可以按药品或化妆品制剂的一般方法制取。
本发明的组合物，如果需要，可以含有助溶剂(例如脂肪酸酯，多元醇脂肪酸酯，中链脂肪酸甘油酯，菜子油或烷基甘油醚)，表面活性剂(例如非离子表面活性剂，卵磷脂衍生物或聚合物乳化剂)，乳化稳定剂，吸收促进剂等等。本发明的优点
本发明提供的含敏乐定的组合物可以长时间地保持不变颜色。
实施
下列实施例和实验将对本发明做更详细的说明。其中的pH值是用DKK-Toa公司生产的带有一个玻璃电极的酸度计对5ml制剂检测5分钟测定的。
实施例1
将0.5ml磷酸加到5g敏乐定，30g 1，3-丁二醇，50g乙醇和0.5g二丁基羟基甲苯中，加入纯净水使此混合物的总体积达到100ml，搅拌溶解后生成一种洗液型组合物，pH值为6.0。
实施例2
将0.9ml磷酸加到5g敏乐定，30g 1，3-丁二醇，50g乙醇和0.1g二丁基羟基甲苯中，加入纯净水使此混合物的总体积达到100ml，搅拌溶解后生成一种洗液型组合物，pH值为5.5。
实施例3
将0.55g柠檬酸加到5g敏乐定，30g 1，3-丁二醇，50g乙醇和0.5g二丁基羟基甲苯中，加入纯净水使此混合物的总体积达到100ml，搅拌溶解后生成一种洗液型组合物，pH值为6.4。
实施例4
将0.02ml磷酸加到3g敏乐定，30g 1，3-丁二醇，50g乙醇和0.5g丁基羟基苯甲醚中，加入纯净水使此混合物的总体积达到100ml，搅拌溶解后生成一种洗液型组合物，pH值为7.0。
实施例5
将0.3ml磷酸加到5g敏乐定，52g丙二醇，25g乙醇和0.5g二丁基羟基甲苯中，加入纯净水使此混合物的总体积达到100ml，搅拌溶解后生成一种洗液型组合物，pH值为6.0。比较实施例1
将纯净水加到3g敏乐定，30g 1，3-丁二醇，50g乙醇和0.5g丁基羟基甲苯的混合物中，使其总体积达到100ml，将混合物搅拌溶解后生成一种洗液型组合物，pH值为8.8。比较实施例2
将5g敏乐定，52g丙二醇和25g乙醇混合在一起，加入纯净水使其总体积达到100ml，将混合物搅拌溶解后生成一种洗液型组合物，pH值为8.7。比较实施例3
将5g敏乐定，52g丙二醇，25g乙醇和0.3ml磷酸混合在一起，加入纯净水使其总体积达到100ml，将混合物搅拌溶解后生成一种洗液型组合物，pH值为6.0。比较实施例4
将5g敏乐定，52g丙二醇和25g乙醇和0.5g二丁基羟基甲苯混合在一起，加入纯净水使其总体积达到100ml，将混合物搅拌溶解后生成一种洗液型组合物，pH值为8.7。实验1
在5只PET(聚对苯二甲酸乙二醇酯)瓶中分别倒入实施例1、2、3、4和比较实施例1的组合物，50℃下储存一个月，观察并按下列标准判定其色调变化程度：
0：未见着色，作为商品不成问题。
1：轻微着色，但作为商品不成问题。
2：见有着色，作为商品会有问题。
结果见表1。
表1
制剂 实施例1 实施例2 实施例3 实施例4 比较实施例1
 pH值 6  5.5  6.4  7  8.8
评价 0  1  0  1  2
在比较实施例1中观察到有着色，因此判定其作为商品会有问题。在实施例1～实施例4中未见着色或仅见轻微着色，因此判定其作为商品没有问题。实验2
在4只PET(聚对苯二甲酸乙二醇酯)瓶中分别倒入实施例5和比较实施例2、3和4的组合物，50℃下储存一个月后用液体溶气计(Beckman公司产品)在420nm处测其吸收值。
结果见表2。
表2
制剂 实施例5 比较实施例2 比较实施例3 比较实施例4
pH值 6  8.7  6  8.7
BHT 0.5g  0g  0g  0.5g
吸收度(420nm) 0.013  0.021  0.058  0.039
比较实施例2和3的结果表明，含敏乐定组合物的着色程度因pH值的降低而加深了。此外，比较实施例4的结果表明，加入丁基化羟基甲苯(BHT)后着色加深了，没有起到有保护作用。
相反，实施例5的结果表明，它比任何一个比较实施例都表现出了非凡的保护作用。

Claims (10)

1.一种含敏乐定的组合物，它包括一种抗氧化剂并且pH值为5.5～7.0。
2.一种含敏乐定的组合物，它包括一种抗氧化剂并且pH值为5.5～6.3。
3.权利要求1或2的含敏乐定的组合物，其中所述抗氧化剂是选自下列的一种或多种化合物：二丁基羟基甲苯，丁基羟基苯甲醚，异抗坏血酸，乙二胺四乙酸二钠，柠檬酸异丙基酯，倍酸丙基酯，愈创木酸，α-硫代甘油，二氯异氰尿酸钾，2，6-二-叔丁基-4-甲基苯酚，大豆卵磷脂，巯基乙酸钠，硫羟苹果酸钠，棕榈酸抗坏血酸酯，2-巯基苯并咪唑和氧化喹啉硫酸盐。
4.权利要求1或2的含敏乐定的组合物，其中所述抗氧化剂为选自下列的一种或多种提取物：丁香、天竺葵、大黄、黄柏树皮、芍药根、幕天树皮、黄连的根茎、橘皮、蛇麻草、黄芩根、樟树皮、甘草、桔梗根、生姜、红花和日本当归根的提取物。
5.权利要求1或2的含敏乐定的组合物，其中所述抗氧化剂为二丁基羟基甲苯或丁基羟基苯甲醚。
6.权利要求1至5中任一项的含敏乐定的组合物，其中敏乐定的浓度为1％～10％(质量)。
7.权利要求1至5中任一项的含敏乐定的组合物，其中敏乐定的浓度为3％～6％(质量)。
8.权利要求1至7中任一项的含敏乐定的组合物，其中抗氧化剂的量，与敏乐定的质量比为0.005∶1～0.5∶1。
9.权利要求1至8中任一项的含敏乐定的组合物，其中还包括一种多元醇。
列的一种或二种化合物：二丁基羟基甲苯，丁基羟基苯甲醚，异抗坏血酸，乙二胺四乙酸二钠，柠檬酸异丙基酯，倍酸丙基酯，愈创木酸，α-硫代甘油，二氯异氰尿酸钾，2，6-二-叔丁基-4-甲基苯酚，大豆卵磷脂，巯基乙酸钠，硫羟苹果酸钠，棕榈酸抗坏血酸酯，2-巯基苯并咪唑和氧化喹啉硫酸盐。
13.权利要求11的防止该组合物变色的方法，其中所述抗氧化剂为选自下列的一种或二种提取物：丁香、天竺葵、大黄、黄柏树皮、芍药根、幕天树皮、黄连的根茎、橘皮、蛇麻草、黄芩根、樟树皮、甘草、桔梗根、生姜、红花和日本当归根的提取物。
CNB018106498A 2000-04-07 2001-04-05 含敏乐定的制剂 Expired - Fee Related CN1279914C (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014178617A1 (en) * 2013-04-29 2014-11-06 Korea United Pharm. Inc. Oral formulation comprising extract of coptis rhizome having masked bitter taste

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO983897A0 (en) 1997-10-17 1997-11-06 Soltec Research Pty Ltd Topical antifungal composition
AUPP310798A0 (en) 1998-04-22 1998-05-14 Soltec Research Pty Ltd Vehicle system for a composition comprising a piperidinopyrimidine derivative
JP5785353B2 (ja) * 2004-02-27 2015-09-30 大正製薬株式会社 眼科用剤
TW200534875A (en) * 2004-04-23 2005-11-01 Lonza Ag Personal care compositions and concentrates for making the same
JP2006022091A (ja) * 2004-06-09 2006-01-26 Dai Ichi Seiyaku Co Ltd 育毛用組成物
JP5040060B2 (ja) * 2004-10-14 2012-10-03 大正製薬株式会社 メチオニン配合内服液剤
CA2673841A1 (en) * 2006-12-20 2008-06-26 Taisho Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for alopecia
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
JP5286999B2 (ja) * 2008-07-10 2013-09-11 大正製薬株式会社 ミノキシジル含有液剤
EP2344198B1 (en) * 2008-09-27 2020-11-04 Jina Pharmaceuticals Inc. Lipid based pharmaceutical preparations for topical application
US8470833B2 (en) 2009-12-15 2013-06-25 Mcneil-Ppc, Inc. Hair growth and/or regrowth compositions
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
WO2014119186A1 (ja) * 2013-01-31 2014-08-07 富士フイルム株式会社 乳化組成物
JP6199066B2 (ja) * 2013-04-24 2017-09-20 ロート製薬株式会社 ミノキシジル含有外用組成物
KR102320051B1 (ko) 2013-10-03 2021-10-29 다우 파마슈티컬 사이언시즈, 인코포레이티드 안정화된 에피나코나졸 조성물
CA3052643A1 (en) 2013-11-22 2015-05-28 Bausch Health Ireland Limited Anti-infective methods, compositions, and devices
JP6736889B2 (ja) * 2015-01-23 2020-08-05 大正製薬株式会社 外用組成物
JP6052686B2 (ja) * 2015-02-06 2016-12-27 ダイヤ製薬株式会社 外用液剤
JP6528194B2 (ja) * 2015-02-06 2019-06-12 ダイヤ製薬株式会社 ミノキシジル含有外用液剤および外用液剤の製造方法
JP6825354B2 (ja) * 2015-12-29 2021-02-03 大正製薬株式会社 外用組成物
JP7346010B2 (ja) * 2016-09-15 2023-09-19 大正製薬株式会社 外用組成物
KR102000217B1 (ko) * 2017-08-08 2019-07-15 에스씨엠생명과학 주식회사 Cxcl1 단백질 및 미녹시딜을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물
JP2017206558A (ja) * 2017-08-22 2017-11-24 ロート製薬株式会社 ミノキシジル含有外用組成物
JP2020023467A (ja) * 2018-01-19 2020-02-13 ロート製薬株式会社 外用製剤、液切れ性を改善する方法、および、液切れ性改善剤
JP7304463B2 (ja) * 2018-01-29 2023-07-06 富士化学工業株式会社 ミノキシジル含有外用組成物
JP2019014764A (ja) * 2018-11-06 2019-01-31 ロート製薬株式会社 ミノキシジル含有外用組成物
JP7488634B2 (ja) * 2019-07-10 2024-05-22 ロート製薬株式会社 外用製剤
JP7575722B2 (ja) * 2019-10-28 2024-10-30 大正製薬株式会社 外用医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601359B1 (fr) * 1986-07-09 1988-10-28 Cird Nouveaux derives bicycliques naphtaleniques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique.
FR2621912B1 (fr) * 1987-10-16 1990-03-02 Oreal Nouveaux derives du norbornane, leur procede de preparation et compositions cosmetique et medicamenteuse les contenant
ATE110954T1 (de) * 1988-01-29 1994-09-15 Peter H Proctor Haarwachstumanregung mit nitroxyd und anderen radikalen.
FR2641184B1 (fr) * 1988-12-30 1991-04-05 Oreal Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, a base de derives de pyrimidine et de filtres solaires
JP2511714B2 (ja) * 1989-12-05 1996-07-03 一丸ファルコス株式会社 植物由来抽出成分からなるフケ菌発育阻害剤を含有する皮膚・頭皮・頭髪用化粧料
MX9305615A (es) * 1992-09-14 1994-05-31 Walter P Smith Composicion para el acondicionamiento de la piel, su aplicacion y fabricacion.
JP4467085B2 (ja) * 1996-01-05 2010-05-26 大正製薬株式会社 ヒノキチオール含有組成物
FR2756561B1 (fr) * 1996-12-04 1999-01-08 Cird Galderma Composes heteroaryles, compositions pharmaceutiques et cosmetiques les contenant et utilisations
JPH11349451A (ja) * 1998-06-08 1999-12-21 Taisho Pharmaceut Co Ltd 育毛剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014178617A1 (en) * 2013-04-29 2014-11-06 Korea United Pharm. Inc. Oral formulation comprising extract of coptis rhizome having masked bitter taste

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