CN1720248A - 1－氮杂双环[2.2.2]八取代的呋喃并[2,3－c]吡啶基甲酰胺的晶体富马酸盐及其组合物和制备方法 - Google Patents

1－氮杂双环[2.2.2]八取代的呋喃并[2,3－c]吡啶基甲酰胺的晶体富马酸盐及其组合物和制备方法 Download PDF

Info

Publication number: CN1720248A
Authority: CN; China
Prior art keywords: fumarate; disease; salt; described salt; relevant
Prior art date: 2002-12-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CNA200380105166XA

Other languages

English (en)

Chinese (zh)

Inventor

J·G·塞尔伯

B·D·休伊特

D·W·拉帕斯

D·G·威希卡

A·Y·谢赫

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co LLC

Original Assignee

Pharmacia and Upjohn Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-06

Filing date

2003-12-01

Publication date

2006-01-11

2003-12-01 Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC

2006-01-11 Publication of CN1720248A publication Critical patent/CN1720248A/zh

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CNA200380105166XA 2002-12-06 2003-12-01 1－氮杂双环[2.2.2]八取代的呋喃并[2,3－c]吡啶基甲酰胺的晶体富马酸盐及其组合物和制备方法 Pending CN1720248A (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43161902P	2002-12-06	2002-12-06
US60/431,619		2002-12-06

Publications (1)

Publication Number	Publication Date
CN1720248A true CN1720248A (zh)	2006-01-11

Family

ID=32507764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CNA200380105166XA Pending CN1720248A (zh)	2002-12-06	2003-12-01	1－氮杂双环[2.2.2]八取代的呋喃并[2,3－c]吡啶基甲酰胺的晶体富马酸盐及其组合物和制备方法

Country Status (22)

Country	Link
US (1)	US20050165047A1 (fr)
EP (1)	EP1572700A1 (fr)
JP (1)	JP2006510664A (fr)
KR (1)	KR20050087826A (fr)
CN (1)	CN1720248A (fr)
AR (1)	AR042295A1 (fr)
AU (1)	AU2003302911A1 (fr)
BR (1)	BR0317019A (fr)
CA (1)	CA2506529A1 (fr)
CR (1)	CR7859A (fr)
EA (1)	EA200500738A1 (fr)
EC (1)	ECSP055834A (fr)
HR (1)	HRP20050494A2 (fr)
IS (1)	IS7844A (fr)
MA (1)	MA27604A1 (fr)
MX (1)	MXPA05005943A (fr)
NO (1)	NO20052560L (fr)
OA (1)	OA12968A (fr)
PL (1)	PL377052A1 (fr)
TW (1)	TW200427691A (fr)
WO (1)	WO2004052894A1 (fr)
ZA (1)	ZA200503988B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6670178B1 (en)	1992-07-10	2003-12-30	Transkaryotic Therapies, Inc.	In Vivo production and delivery of insulinotropin for gene therapy
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
WO2004083388A2 (fr)	2003-03-14	2004-09-30	Bristol-Myers Squibb Company	Polynucleotide codant un nouveau variant de recepteur de hm74, hgprbmy74 couple a une proteine g humaine
US8383657B2 (en)	2007-12-21	2013-02-26	Abbott Laboratories	Thiazolylidine urea and amide derivatives and methods of use thereof
JP2011511845A (ja) *	2008-02-13	2011-04-14	ターガセプト，インコーポレイテッド	アルファ７（α７）ニコチン作動薬と抗精神病薬との組合せ物
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
AR081402A1 (es)	2010-05-17	2012-08-29	Envivo Pharmaceuticals Inc	Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
CA2872005A1 (fr)	2012-05-08	2013-11-14	Forum Pharmaceuticals, Inc.	Procedes de maintien, de traitement ou d'amelioration de la fonction cognitive

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988002751A1 (fr) *	1986-10-13	1988-04-21	Asahi Kasei Kogyo Kabushiki Kaisha	Derives de pyridine
AR036040A1 (es) *	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen

2003
- 2003-12-01 EA EA200500738A patent/EA200500738A1/ru unknown
- 2003-12-01 HR HR20050494A patent/HRP20050494A2/hr not_active Application Discontinuation
- 2003-12-01 BR BR0317019-5A patent/BR0317019A/pt unknown
- 2003-12-01 MX MXPA05005943A patent/MXPA05005943A/es not_active Application Discontinuation
- 2003-12-01 JP JP2004558940A patent/JP2006510664A/ja active Pending
- 2003-12-01 OA OA1200500173A patent/OA12968A/en unknown
- 2003-12-01 KR KR1020057010196A patent/KR20050087826A/ko not_active Ceased
- 2003-12-01 CN CNA200380105166XA patent/CN1720248A/zh active Pending
- 2003-12-01 WO PCT/IB2003/005607 patent/WO2004052894A1/fr not_active Ceased
- 2003-12-01 CA CA002506529A patent/CA2506529A1/fr not_active Abandoned
- 2003-12-01 PL PL377052A patent/PL377052A1/pl not_active Application Discontinuation
- 2003-12-01 AU AU2003302911A patent/AU2003302911A1/en not_active Abandoned
- 2003-12-01 EP EP03812627A patent/EP1572700A1/fr not_active Withdrawn
- 2003-12-04 AR ARP030104471A patent/AR042295A1/es unknown
- 2003-12-05 TW TW092134360A patent/TW200427691A/zh unknown
2004
- 2004-10-08 US US10/962,071 patent/US20050165047A1/en not_active Abandoned
2005
- 2005-05-12 IS IS7844A patent/IS7844A/is unknown
- 2005-05-17 ZA ZA200503988A patent/ZA200503988B/en unknown
- 2005-05-26 NO NO20052560A patent/NO20052560L/no not_active Application Discontinuation
- 2005-06-03 EC EC2005005834A patent/ECSP055834A/es unknown
- 2005-06-06 MA MA28315A patent/MA27604A1/fr unknown
- 2005-06-06 CR CR7859A patent/CR7859A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL377052A1 (pl)	2006-01-23
WO2004052894A1 (fr)	2004-06-24
OA12968A (en)	2006-10-13
ECSP055834A (es)	2005-08-11
ZA200503988B (en)	2006-09-27
EP1572700A1 (fr)	2005-09-14
HRP20050494A2 (en)	2005-10-31
TW200427691A (en)	2004-12-16
JP2006510664A (ja)	2006-03-30
NO20052560L (no)	2005-08-17
CR7859A (es)	2005-07-08
BR0317019A (pt)	2005-10-25
MA27604A1 (fr)	2005-11-01
CA2506529A1 (fr)	2004-06-24
MXPA05005943A (es)	2005-08-18
IS7844A (is)	2005-05-12
NO20052560D0 (no)	2005-05-26
KR20050087826A (ko)	2005-08-31
US20050165047A1 (en)	2005-07-28
EA200500738A1 (ru)	2005-12-29
AR042295A1 (es)	2005-06-15
AU2003302911A1 (en)	2004-06-30

Legal Events

Date	Code	Title	Description
2006-01-11	C06	Publication
2006-01-11	PB01	Publication
2006-03-01	C10	Entry into substantive examination
2006-03-01	SE01	Entry into force of request for substantive examination
2006-05-26	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1081951 Country of ref document: HK
2007-08-08	C02	Deemed withdrawal of patent application after publication (patent law 2001)
2007-08-08	WD01	Invention patent application deemed withdrawn after publication
2012-07-13	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1081951 Country of ref document: HK

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