CN1759115A - 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途 - Google Patents

埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途 Download PDF

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Publication number
CN1759115A
CN1759115A CNA038225611A CN03822561A CN1759115A CN 1759115 A CN1759115 A CN 1759115A CN A038225611 A CNA038225611 A CN A038225611A CN 03822561 A CN03822561 A CN 03822561A CN 1759115 A CN1759115 A CN 1759115A
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aliphatic group
hydrogen
heteroaryl
aryl
compound
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Pending
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CNA038225611A
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English (en)
Chinese (zh)
Inventor
赛缪尔·J·达尼谢夫斯凯
亚力克西·里夫金
吉村文彦
安娜·以斯贴·加瓦尔达·奥尔特加
朝永新
舒定朝
董华金
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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Priority claimed from US10/402,004 external-priority patent/US6921769B2/en
Priority claimed from US10/435,408 external-priority patent/US7649006B2/en
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CN1759115A publication Critical patent/CN1759115A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNA038225611A 2002-08-23 2003-08-22 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途 Pending CN1759115A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US40582302P 2002-08-23 2002-08-23
US40858902P 2002-09-06 2002-09-06
US42312902P 2002-11-01 2002-11-01
US45615903P 2003-03-20 2003-03-20
US10/402,004 US6921769B2 (en) 2002-08-23 2003-03-28 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 US7649006B2 (en) 2002-08-23 2003-05-09 Synthesis of epothilones, intermediates thereto and analogues thereof
US49674103P 2003-08-21 2003-08-21
PCT/US2003/026367 WO2004018478A2 (en) 2002-08-23 2003-08-22 Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Related Child Applications (1)

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CN2011103358062A Division CN102532120A (zh) 2002-08-23 2003-08-22 埃坡霉素(epothilone)，合成埃坡霉素的中间体，其类似物及其用途

Publications (1)

Publication Number Publication Date
CN1759115A true CN1759115A (zh) 2006-04-12

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CNA038225611A Pending CN1759115A (zh) 2002-08-23 2003-08-22 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途
CN2011103358062A Pending CN102532120A (zh) 2002-08-23 2003-08-22 埃坡霉素(epothilone)，合成埃坡霉素的中间体，其类似物及其用途

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Country Status (18)

Country Link
US (1) US7875638B2 (2)
EP (3) EP2186811A1 (2)
JP (2) JP4791183B2 (2)
KR (1) KR101173510B1 (2)
CN (2) CN1759115A (2)
AT (2) ATE450534T1 (2)
AU (1) AU2003260002B2 (2)
CA (1) CA2496477C (2)
DE (2) DE60310916T2 (2)
DK (2) DK1767535T3 (2)
ES (2) ES2281692T3 (2)
IL (1) IL167046A (2)
MX (1) MXPA05002113A (2)
NZ (1) NZ538522A (2)
PH (1) PH12012501351A1 (2)
PT (2) PT1506203E (2)
SI (1) SI1767535T1 (2)
WO (1) WO2004018478A2 (2)

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Publication number Priority date Publication date Assignee Title
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