CO5140077A1 - Complejo estable insoluble en agua, composiciones farma- ceuticas que lo contienen y metodos para su preparacion . . - Google Patents
Complejo estable insoluble en agua, composiciones farma- ceuticas que lo contienen y metodos para su preparacion . .Info
- Publication number
- CO5140077A1 CO5140077A1 CO99059117A CO99059117A CO5140077A1 CO 5140077 A1 CO5140077 A1 CO 5140077A1 CO 99059117 A CO99059117 A CO 99059117A CO 99059117 A CO99059117 A CO 99059117A CO 5140077 A1 CO5140077 A1 CO 5140077A1
- Authority
- CO
- Colombia
- Prior art keywords
- weight
- active compound
- water insoluble
- polymer
- ionic polymer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un complejo insoluble en agua que comprende al menos 20% en peso de un polímero iónico insoluble en agua que tiene un peso molecular superior a 80.000 D (1.32 x 10-19 g) y una temperatura de transición vítrea igual o superior a 50° C, y de 0.1 a 80% en peso de un compuesto activo estable y, amorfo que tiene una solubilidad acuosa inferior a 1 mg/ml.Un método para la preparación de un complejo insoluble en agua compuesto de al menos un 20% en peso de un polímero iónico que tiene un peso molecular superior a 80.000 D (1.32 x 10-19 g) y una temperatura de transición vítrea igual o superior a 50° C y, de 0.1 a 80% en peso de un compuesto activo estable y amorfo, preparado mediante: (a) la fusión conjunta del compuesto terapéuticamente activo y el polímero iónico; y(b) enfriamiento de la mezcla resultante del paso (a).Una composición farmacéutica que comprende un complejo insoluble en agua compuesto de al menos 20% en peso de un polímero iónico insoluble en agua que tiene un peso molecular superior a 80.000 D (1.32 x 10-19 g) y una temperatura de transición vítrea igual o superior a 50° C, de 0.1 a 80% en peso de un compuesto activo que tiene una solubilidad acuosa inferior a 1 mg/ml, y un soporte.2Un método para la preparación de una composición farmacéutica que comprende un complejo insoluble en agua compuesto de al menos un 20% en peso de un polímero iónico insoluble en agua que tiene un peso molecular superior a 80.000 D (1.32 x 10-19 g) y una temperatura de transición vítrea igual o superior a 50° C y, de 0.1 a 80% en peso de un compuesto activo que tiene una solubilidad acuosa inferior a 1 mg/ml, que comprende:(a) la disolución del compuesto terapéuticamente activo y el polímero iónico en un disolvente orgánico que provee buena solubilidad para ambos el compuesto activo y el polímero;(b) la puesta en contacto de la solución del paso (a) con una solución acuosa a un pH en el cual el polímero iónico es escasamente soluble, con lo cual tiene lugar la microprecipitación del compuesto terapéuticamente activo y el polímero iónico en forma de un complejo compuesto/polímero;(c) la mezcla del complejo compuesto/polímero del paso (b) con un soporte y/o ingredientes adicionales convencionales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10133698P | 1998-09-22 | 1998-09-22 | |
| US13653199P | 1999-05-28 | 1999-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5140077A1 true CO5140077A1 (es) | 2002-03-22 |
Family
ID=26798138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99059117A CO5140077A1 (es) | 1998-09-22 | 1999-09-17 | Complejo estable insoluble en agua, composiciones farma- ceuticas que lo contienen y metodos para su preparacion . . |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6350786B1 (es) |
| EP (1) | EP0988863B2 (es) |
| JP (5) | JP2000095708A (es) |
| KR (1) | KR100362019B1 (es) |
| CN (1) | CN1201821C (es) |
| AR (2) | AR022096A1 (es) |
| AT (1) | ATE265232T1 (es) |
| AU (1) | AU770745B2 (es) |
| BR (1) | BR9904283A (es) |
| CA (1) | CA2282906C (es) |
| CO (1) | CO5140077A1 (es) |
| CZ (1) | CZ300215B6 (es) |
| DE (1) | DE69916733T3 (es) |
| DK (1) | DK0988863T4 (es) |
| ES (1) | ES2218918T5 (es) |
| HR (1) | HRP990287B1 (es) |
| HU (1) | HU228341B1 (es) |
| ID (1) | ID24034A (es) |
| IL (1) | IL131957A (es) |
| MA (1) | MA26692A1 (es) |
| MY (1) | MY124377A (es) |
| NO (1) | NO326928B1 (es) |
| NZ (1) | NZ337884A (es) |
| PE (1) | PE20001049A1 (es) |
| PL (1) | PL202757B1 (es) |
| PT (1) | PT988863E (es) |
| RS (1) | RS50193B (es) |
| RU (1) | RU2240827C2 (es) |
| SG (1) | SG97131A1 (es) |
| SI (1) | SI0988863T2 (es) |
| TR (1) | TR199902324A3 (es) |
| TW (1) | TWI234465B (es) |
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| WO2020114853A1 (en) | 2018-12-03 | 2020-06-11 | H. Lundbeck A/S | Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine |
| TWI849043B (zh) | 2019-01-25 | 2024-07-21 | 英屬開曼群島商百濟神州有限公司 | B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途 |
| IL294928A (en) | 2020-01-24 | 2022-09-01 | Nanocopoeia Llc | Amorphous solid dispersions of dasatinib and uses thereof |
| EP4096791A1 (en) | 2020-01-31 | 2022-12-07 | Nanocopoeia LLC | Amorphous nilotinib microparticles and uses thereof |
| JP7705715B2 (ja) | 2020-03-03 | 2025-07-10 | デクセリアルズ株式会社 | 画像表示装置の製造方法 |
| WO2021222739A1 (en) | 2020-04-30 | 2021-11-04 | Nanocopoeia, Llc | Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib |
| US11980619B2 (en) | 2021-07-28 | 2024-05-14 | Nanocopoeia, Llc | Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses |
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| JPS51118816A (en) * | 1975-04-08 | 1976-10-19 | Meiji Seika Kaisha Ltd | A process for stabilizing non-crystalloidal solid |
| US4344934A (en) * | 1978-11-20 | 1982-08-17 | American Home Products Corporation | Therapeutic compositions with enhanced bioavailability |
| PT83812B (en) * | 1985-11-27 | 1988-03-15 | Syntex Inc | Process for preparing amorphous benzimidazole derivatives |
| GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| JP2528706B2 (ja) † | 1988-05-30 | 1996-08-28 | ゼリア新薬工業株式会社 | ジヒドロピリジン化合物の製剤組成物 |
| USRE36736E (en) | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
| JPH0729926B2 (ja) † | 1989-07-25 | 1995-04-05 | 大塚製薬株式会社 | 易吸収性製剤用組成物 |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| WO1992018106A1 (fr) † | 1991-04-16 | 1992-10-29 | Nippon Shinyaku Co., Ltd. | Procede de production d'une dispersion solide |
| US5281420A (en) | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| TW493991B (en) | 1995-05-08 | 2002-07-11 | Novartis Ag | Pharmaceutical composition for oral administration of active agent having low water solubility and process for preparation of the same |
| GB9511220D0 (en) † | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
| FR2736550B1 (fr) * | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| DE69628276T2 (de) * | 1995-07-26 | 2004-04-08 | Kyowa Hakko Kogyo Co., Ltd. | Zubereitung von xanthinderivaten als feste dispersion |
| CA2231050A1 (en) † | 1995-09-07 | 1997-03-13 | Biovail International Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
| DE19548624A1 (de) | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JPH09208459A (ja) * | 1996-02-07 | 1997-08-12 | Eisai Co Ltd | 溶解性を改良した製剤 |
| CN1304058C (zh) | 1996-03-12 | 2007-03-14 | Pg－Txl有限公司 | 水溶性紫杉醇产品 |
| ATE273002T1 (de) * | 1996-06-28 | 2004-08-15 | Schering Corp | Feste lösung eines fungizids mit erhöhter bioverfügbarkeit |
| PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| US6229011B1 (en) | 1997-08-22 | 2001-05-08 | Hoffman-La Roche Inc. | N-aroylphenylalanine derivative VCAM-1 inhibitors |
| PT1064279E (pt) | 1998-03-17 | 2003-10-31 | Hoffmann La Roche | Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular |
-
1999
- 1999-09-07 US US09/391,060 patent/US6350786B1/en not_active Expired - Lifetime
- 1999-09-13 AT AT99117908T patent/ATE265232T1/de active
- 1999-09-13 DK DK99117908T patent/DK0988863T4/da active
- 1999-09-13 SI SI9930573T patent/SI0988863T2/sl unknown
- 1999-09-13 EP EP99117908A patent/EP0988863B2/en not_active Expired - Lifetime
- 1999-09-13 PT PT99117908T patent/PT988863E/pt unknown
- 1999-09-13 DE DE69916733T patent/DE69916733T3/de not_active Expired - Lifetime
- 1999-09-13 ES ES99117908T patent/ES2218918T5/es not_active Expired - Lifetime
- 1999-09-16 IL IL13195799A patent/IL131957A/xx not_active IP Right Cessation
- 1999-09-17 SG SG9904570A patent/SG97131A1/en unknown
- 1999-09-17 PE PE1999000947A patent/PE20001049A1/es not_active IP Right Cessation
- 1999-09-17 NZ NZ337884A patent/NZ337884A/xx not_active IP Right Cessation
- 1999-09-17 CO CO99059117A patent/CO5140077A1/es unknown
- 1999-09-17 CZ CZ0330499A patent/CZ300215B6/cs not_active IP Right Cessation
- 1999-09-20 ID IDP990878D patent/ID24034A/id unknown
- 1999-09-20 HR HR990287 patent/HRP990287B1/xx not_active IP Right Cessation
- 1999-09-20 TW TW088116184A patent/TWI234465B/zh not_active IP Right Cessation
- 1999-09-20 MY MYPI99004065A patent/MY124377A/en unknown
- 1999-09-20 HU HU9903189A patent/HU228341B1/hu unknown
- 1999-09-20 AR ARP990104725A patent/AR022096A1/es not_active Application Discontinuation
- 1999-09-20 CA CA2282906A patent/CA2282906C/en not_active Expired - Lifetime
- 1999-09-20 AU AU48807/99A patent/AU770745B2/en not_active Expired
- 1999-09-21 RU RU99120377/15A patent/RU2240827C2/ru active
- 1999-09-21 JP JP11267142A patent/JP2000095708A/ja not_active Withdrawn
- 1999-09-21 CN CNB991194063A patent/CN1201821C/zh not_active Expired - Lifetime
- 1999-09-21 NO NO19994583A patent/NO326928B1/no not_active IP Right Cessation
- 1999-09-21 MA MA25778A patent/MA26692A1/fr unknown
- 1999-09-21 RS YUP-473/99A patent/RS50193B/sr unknown
- 1999-09-21 BR BR9904283-5A patent/BR9904283A/pt not_active Application Discontinuation
- 1999-09-21 TR TR1999/02324A patent/TR199902324A3/tr unknown
- 1999-09-22 KR KR1019990041130A patent/KR100362019B1/ko not_active Expired - Lifetime
- 1999-09-22 PL PL335592A patent/PL202757B1/pl unknown
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2007
- 2007-06-06 JP JP2007150911A patent/JP2007224048A/ja active Pending
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2011
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