CR10451A - Acidos bifenilocarbocilicos substituidos y sus derivados - Google Patents

Acidos bifenilocarbocilicos substituidos y sus derivados

Info

Publication number
CR10451A
CR10451A CR10451A CR10451A CR10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A CR 10451 A CR10451 A CR 10451A
Authority
CR
Costa Rica
Prior art keywords
substituted
bifenylocarboyclic
derivatives
acids
group
Prior art date
Application number
CR10451A
Other languages
English (en)
Inventor
Wilson Francis
Reid Alison
Reader Valerie
John Harrison Richard
Sunose Mihiro
Hernandez-Perni Remedios
Mayor Jeremy
Boussard Cyrille
Smelt Kathryn
Taylor Jess
Leformal Adeline
Cansfield Andrew
Burckhardt Svenja
Yung Ho Chih
Zhang Yan
Original Assignee
Ortho Macneil Pharmaceutical Inc
Cellzome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Macneil Pharmaceutical Inc, Cellzome Ltd filed Critical Ortho Macneil Pharmaceutical Inc
Publication of CR10451A publication Critical patent/CR10451A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

l o ester del mismo; mas aun, la invencion se relaciona con el uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y con su uso para la modulacion de la actividad y-secretasa, en donde A es O, NH, S; X es un enlace o grupo -CR5R6 Y es un grupo carboxi-C(O)OH o un grupo tetrazol sustituido o no sustituido.
CR10451A 2006-04-21 2008-11-21 Acidos bifenilocarbocilicos substituidos y sus derivados CR10451A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
CR10451A true CR10451A (es) 2009-03-31

Family

ID=36688012

Family Applications (2)

Application Number Title Priority Date Filing Date
CR10375A CR10375A (es) 2006-04-21 2008-10-17 Acidos bifenilcarboxilicos sustituidos y sus derivados
CR10451A CR10451A (es) 2006-04-21 2008-11-21 Acidos bifenilocarbocilicos substituidos y sus derivados

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR10375A CR10375A (es) 2006-04-21 2008-10-17 Acidos bifenilcarboxilicos sustituidos y sus derivados

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194852A0 (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Ｇｓｍ 중간체
BRPI0818773A2 (pt) 2007-10-19 2015-04-14 Janssen Pharmaceutica Nv Moduladores de gama-secretase ligados a carbono
AU2008312612B2 (en) 2007-10-19 2013-11-28 Janssen Pharmaceutica, N.V. Piperidinyl and piperazinyl modulators of gamma-secretase
KR20100082351A (ko) * 2007-10-19 2010-07-16 얀센 파마슈티카 엔.브이. γ-세크레타아제의 아민 결합된 조절제
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
EP2488031A4 (en) 2009-10-16 2014-07-23 Merck Sharp & Dohme DIARYL ETHER DERIVATIVES AS A NOTCH-PROOFING GAMMETRETASE INHIBITOR
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
CA2828764A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
WO2001078721A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research Aβ42 LOWERING AGENTS
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
NZ537206A (en) * 2002-06-27 2007-06-29 Astellas Pharma Inc Aminoalcohol derivatives
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
TW200621227A (en) * 2004-08-24 2006-07-01 Kissei Pharmaceutical Medicament for preventing or treating fatty liver
JP5155171B2 (ja) * 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物

Also Published As

Publication number Publication date
SI1849762T1 (sl) 2009-12-31
TNSN08413A1 (en) 2010-04-14
AR060568A1 (es) 2008-06-25
CA2650006A1 (en) 2007-11-01
EP2021314A1 (en) 2009-02-11
PE20080364A1 (es) 2008-05-16
ES2400530T3 (es) 2013-04-10
WO2007124394A1 (en) 2007-11-01
TW200815320A (en) 2008-04-01
ES2328616T3 (es) 2009-11-16
DE602006007810D1 (de) 2009-08-27
EP1849762B1 (en) 2009-07-15
CN101687758B (zh) 2014-05-14
EA016129B9 (ru) 2012-06-29
AU2007240335A1 (en) 2007-11-01
BRPI0710656A2 (pt) 2011-08-16
EP2021314B1 (en) 2013-01-23
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
IL194790A (en) 2012-12-31
PL1849762T3 (pl) 2009-12-31
UY30301A1 (es) 2007-08-31
DK1849762T3 (da) 2009-10-12
CA2650006C (en) 2016-08-23
US20070293567A1 (en) 2007-12-20
CY1109399T1 (el) 2014-07-02
KR101542255B1 (ko) 2015-08-06
EA200802172A1 (ru) 2009-06-30
AU2007240335B2 (en) 2013-05-02
KR20090024679A (ko) 2009-03-09
GEP20115269B (en) 2011-08-25
GT200900120A (es) 2009-11-16
AP2008004656A0 (en) 2008-10-31
SMP200800061B (it) 2009-07-14
TWI399362B (zh) 2013-06-21
ZA200809856B (en) 2009-06-24
SMAP200800061A (it) 2008-11-19
EP1849762A1 (en) 2007-10-31
NZ573000A (en) 2011-11-25
JP2009544573A (ja) 2009-12-17
PT1849762E (pt) 2009-09-16
CR10375A (es) 2009-02-26
UA95952C2 (ru) 2011-09-26
MX2008013445A (es) 2009-03-10
IL194852A0 (en) 2009-08-03
EA016129B1 (ru) 2012-02-28
IL194790A0 (en) 2009-08-03
CN101687758A (zh) 2010-03-31
MA30475B1 (fr) 2009-06-01
JP5479088B2 (ja) 2014-04-23
MY148953A (en) 2013-06-14

Similar Documents

Publication Publication Date Title
CR10451A (es) Acidos bifenilocarbocilicos substituidos y sus derivados
CO6300954A2 (es) Derivados de tienopiridinonas como activadores de proteina quinasa activados por ampk
UY29919A1 (es) Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones
NI200700107A (es) (bifenil) ácidos carboxílicos y sus derivados
UY30274A1 (es) Derivados sustituidos de la n-(4-metil-1,3-tiazol-2-il)guanidina, formulaciones farmacéuticas conteniéndolo y aplicaciones
UY29927A1 (es) Derivados sustituidos de la 5-fenil-2-tioxo-imidazolin-4-ona y de la 5-fenil-2-amino-imidazolidin-4-ona y sus sales, composiciones y aplicaciones
ECSP088969A (es) Amino-imidazolones y su uso como medicamento para tratar deficiencias cognitivas, enfermedad de alzheimer, neurodegeneración y demencia
CR9721A (es) Compuestos de carbamato para utilizar en el tratamiento de desordenes neurodegenerativos
SV2011003903A (es) Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa iv para el tratamiento o prevencion de diabetes
ECSP099755A (es) Derivados de pirrolopiridina y su uso como inhibidores de bace
CY1107956T1 (el) Χρηση υποκατεστημενων 2-αμινοτετραλινιων για την προληπτικη αντιμετωπιση της νοσου του παρκινσον
UY30408A1 (es) Derivados sustituidos del acetato de 8-(4-metoxifenil)-2,3,4,8-tetrahidroimidazo-[1,5-a]-pirimidin-6-amina, composiciones farmacéuticas y aplicaciones
UY28473A1 (es) Nuevos compuestos
CO6331304A2 (es) Derivados de tienopiridonas como activadores de proteina quinasa activados por amp (ampk)
CR10452A (es) Derivados de terfenilo para el tratamiento de enfermedad de alzheimer
DOP2006000170A (es) Nuevos derivados de espirocromanona
UY30588A1 (es) Compuestos de 4-metilpiridopirimidinona
EA201101672A1 (ru) Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
UY29112A1 (es) Derivados de pirazol condensado, su preparacion y su aplicacion terapeutica
UY30426A1 (es) Derivados sustituidos del 3-(4-metoxi-fenil)-3h-isoindol-1-ilamina trifluoroacetado, sus sales o solvatos farmaceuticamente aceptables, formulaciones farmacéuticas y aplicaciones.
NO20082904L (no) Feksofenadinsupensjonsformulering
EA201270410A1 (ru) Производное инденона и содержащая его фармацевтическая композиция
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
EA201170783A1 (ru) Новые соединения
EA201070478A1 (ru) Дифенилкарбоновые кислоты и их производные

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)