CR10913A - Compuestos de benzotriazinone para mejorar las respuestas sinapticas glutamatergicas - Google Patents

Compuestos de benzotriazinone para mejorar las respuestas sinapticas glutamatergicas

Info

Publication number
CR10913A
CR10913A CR10913A CR10913A CR10913A CR 10913 A CR10913 A CR 10913A CR 10913 A CR10913 A CR 10913A CR 10913 A CR10913 A CR 10913A CR 10913 A CR10913 A CR 10913A
Authority
CR
Costa Rica
Prior art keywords
glutamatergical
improve
brain
benzotriazinone
compounds
Prior art date
Application number
CR10913A
Other languages
English (en)
Inventor
Mueller Rudolf
Lee Stephen
O'hare Sean
Rogers Gary
Rachwal Stan
Street Leslie
Original Assignee
Cortex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortex Pharma Inc filed Critical Cortex Pharma Inc
Publication of CR10913A publication Critical patent/CR10913A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invencion se refiere a la prevencion y tratamiento de la insuficiencia cerebral incluyendo la mejoria en el funcionamiento de los receptores en sinapsis de redes cerebrales responsables por comprtamientos de alto orden. Estas redes cerebrales participan en capacidades cognitivas relacionadas con el deterioro de la memoria, tal como las que se observan en una variedad de demencias y desequilibrios en la actividad neuronal entre diferentes regiones del cerebro.
CR10913A 2007-01-03 2009-07-03 Compuestos de benzotriazinone para mejorar las respuestas sinapticas glutamatergicas CR10913A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87862607P 2007-01-03 2007-01-03

Publications (1)

Publication Number Publication Date
CR10913A true CR10913A (es) 2009-09-21

Family

ID=39608955

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10913A CR10913A (es) 2007-01-03 2009-07-03 Compuestos de benzotriazinone para mejorar las respuestas sinapticas glutamatergicas

Country Status (21)

Country Link
US (1) US20100041647A1 (es)
EP (1) EP2114158B1 (es)
JP (1) JP2010514837A (es)
KR (1) KR20090098999A (es)
CN (1) CN101626686A (es)
AP (1) AP2009004915A0 (es)
AR (1) AR064739A1 (es)
AU (1) AU2007342364A1 (es)
BR (1) BRPI0720323A2 (es)
CA (1) CA2674321A1 (es)
CO (1) CO6210740A2 (es)
CR (1) CR10913A (es)
EA (1) EA200900937A1 (es)
EC (1) ECSP099538A (es)
IL (1) IL199662A0 (es)
MA (1) MA31159B1 (es)
MX (1) MX2009007209A (es)
NZ (1) NZ578290A (es)
TN (1) TN2009000278A1 (es)
WO (1) WO2008085505A1 (es)
ZA (1) ZA200905065B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY154877A (en) 2007-01-03 2015-08-14 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamateric synaptic responses
EA200901546A1 (ru) 2007-05-17 2010-04-30 Кортекс Фармасеутикалс, Инк. Дизамещенные амиды для усиления глутаматергических синаптических ответов
US8119632B2 (en) 2007-08-10 2012-02-21 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
BRPI0814149A2 (pt) 2007-08-10 2011-09-13 Cortex Pharma Inc composto, composição farmacêutica, métodos de tratamento e uso do composto
CN101801939A (zh) * 2007-09-20 2010-08-11 科泰克斯药品公司 用于增强谷氨酸能突触反应的3-取代1,2,3-三嗪-4-酮类和3-取代1,3-嘧啶酮类
US20110257186A1 (en) 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
EP2948135B1 (en) 2013-01-25 2019-01-02 Case Western Reserve University Compositions and methods for the treatment of pervasive development disorders
CN105418525B (zh) * 2015-12-16 2017-12-15 郑州轻工业学院 一种n‑取代1,2,3‑苯并三嗪‑4‑酮的制备方法
CN114716416B (zh) * 2022-04-11 2023-06-16 湖北大学 3,4-二氢吡咯衍生物及其一锅法合成
AU2024240637A1 (en) * 2023-03-21 2025-09-18 Vivozon,Inc. Double regulator for mglur5 and hdac6 and use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723436A (en) * 1971-02-25 1973-03-27 Sun Oil Co Process for aromatic lactams
FR2597103B1 (fr) * 1986-04-15 1988-12-16 Provesan Sa Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
EP1156043B1 (en) * 1992-07-24 2003-11-12 The Regents Of The University Of California Drugs that enhance synaptic responses mediated by ampa receptors
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) * 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
US6713474B2 (en) * 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) * 2000-08-18 2001-10-16 Rohm And Haas Company Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
PL371722A1 (en) * 2001-11-26 2005-06-27 Cortex Pharmaceuticals, Inc. Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
AUPS255202A0 (en) * 2002-05-27 2002-06-13 Monash University Agents and methods for the treatment of disorders associated with motor neuron degeneration
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
MY154877A (en) * 2007-01-03 2015-08-14 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamateric synaptic responses
EA200901546A1 (ru) * 2007-05-17 2010-04-30 Кортекс Фармасеутикалс, Инк. Дизамещенные амиды для усиления глутаматергических синаптических ответов
CN101801939A (zh) * 2007-09-20 2010-08-11 科泰克斯药品公司 用于增强谷氨酸能突触反应的3-取代1,2,3-三嗪-4-酮类和3-取代1,3-嘧啶酮类

Also Published As

Publication number Publication date
AP2009004915A0 (en) 2009-08-31
EP2114158A1 (en) 2009-11-11
TN2009000278A1 (en) 2010-10-18
AR064739A1 (es) 2009-04-22
MX2009007209A (es) 2009-10-12
CO6210740A2 (es) 2010-10-20
WO2008085505A1 (en) 2008-07-17
BRPI0720323A2 (pt) 2016-08-09
AU2007342364A1 (en) 2008-07-17
CN101626686A (zh) 2010-01-13
CA2674321A1 (en) 2008-07-17
EP2114158A4 (en) 2010-05-05
ZA200905065B (en) 2010-04-28
US20100041647A1 (en) 2010-02-18
MA31159B1 (fr) 2010-02-01
KR20090098999A (ko) 2009-09-18
ECSP099538A (es) 2009-12-28
EP2114158B1 (en) 2012-08-08
NZ578290A (en) 2012-03-30
EA200900937A1 (ru) 2009-12-30
IL199662A0 (en) 2010-04-15
JP2010514837A (ja) 2010-05-06

Similar Documents

Publication Publication Date Title
ECSP23004573A (es) Compuestos y composiciones como inhibidores de cinasa de proteina
CR10906A (es) "compuesto (1,2,3)- benzotriazinona sustituido en 3 para incrementar las respuestas sinapticas glutamatergicas"
ECSP10010042A (es) Compuestos y composiciones como moduladores de la actividad de gpr119
ECSP099660A (es) 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas
UY31624A1 (es) Compuestos y composiciones como inhibidores de cinasa
UY34654A (es) Inhibidores de la beta-secretasa
GT201400036A (es) Compuestos y composiciones como inhibidores de la quinasa c - kit
MX350890B (es) Agentes para tratar trastornos que implican la modulación de receptores de rianodina.
CL2013001073A1 (es) Compuestos derivados de 6-amino-nicotinamidas sustituidas, como moduladores de kcnq2/3; composicion farmaceutica que los comprende, util para el tratamiento y/o profilaxis de trastornos y/o enfermedades seleccionadas de dolor, epilepsia, ansiedad, enfermedades cognitivas, entre otras.
UY32937A (es) Compuestos y composiciones como moduladores de la actividad de gpr119
AR047759A1 (es) Derivados de fenil - piperazina como moduladores de receptores muscarnicos
UY31760A (es) Tiazolopiridin-2-iloxi-fenil y tiazolopirazin-2-iloxi-fenil aminas como moduladores de leucotrieno a4 hidrolasa
ECSP088764A (es) Métodos para tratar trastornos cognitivos y otros afines
EA200900937A1 (ru) Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов
UY34991A (es) Inhibidores de la beta-secretasa
UY34407A (es) Nuevos moduladores de trpv3
GT200900310A (es) Macrociclos y sus usos
GT201500124A (es) Forma sòlida de un derivado de dihidro-pirido-oxazina
BR112015013948A2 (pt) derivados diazepínicos úteis como bloqueadores do canal de cálcio no tratamento de dor
CR11549A (es) Composición y procedimiento para el tratamiento de la cercosporiosis del banano
ATE544840T1 (de) Wirkstoff für textilbehandlung
CR20120083A (es) Derivados de oxazina y su uso en el tratamiento de los trastornos neurologicos
CU20120030A7 (es) Derivados de oxazina útiles en el tratamiento de los trastornos neurológicos
BR112018073849A2 (pt) compostos benzenossulfonamida e seu uso como agentes terapêuticos
CR7953A (es) Derivados azabiciclicos de piridiloximetilo bencisoxazol

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)