BRPI0720323A2 - composto, método de tratamento, composição farmacêutica e uso do composto - Google Patents

composto, método de tratamento, composição farmacêutica e uso do composto

Info

Publication number: BRPI0720323A2
Authority: BR; Brazil
Prior art keywords: compound; treatment; pharmaceutical composition; pharmaceutical; composition
Prior art date: 2007-01-03

Application number

BRPI0720323A

Other languages

English (en)

Inventor

Gary A Rogers

Leslie STREET

Rudolf Mueller

Stan Rachwal

Sean M O'hare

Stephen Lee

Original Assignee

Cortex Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-03

Filing date

2007-12-28

Publication date

2016-08-09

2007-12-28 Application filed by Cortex Pharma Inc filed Critical Cortex Pharma Inc

2016-08-09 Publication of BRPI0720323A2 publication Critical patent/BRPI0720323A2/pt

Links

150000001875 compounds Chemical class 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pest Control & Pesticides (AREA)
Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Agronomy & Crop Science (AREA)
Hospice & Palliative Care (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0720323A 2007-01-03 2007-12-28 composto, método de tratamento, composição farmacêutica e uso do composto BRPI0720323A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87862607P	2007-01-03	2007-01-03
PCT/US2007/026415 WO2008085505A1 (en)	2007-01-03	2007-12-28	3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number	Publication Date
BRPI0720323A2 true BRPI0720323A2 (pt)	2016-08-09

Family

ID=39608955

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0720323A BRPI0720323A2 (pt)	2007-01-03	2007-12-28	composto, método de tratamento, composição farmacêutica e uso do composto

Country Status (21)

Country	Link
US (1)	US20100041647A1 (pt)
EP (1)	EP2114158B1 (pt)
JP (1)	JP2010514837A (pt)
KR (1)	KR20090098999A (pt)
CN (1)	CN101626686A (pt)
AP (1)	AP2009004915A0 (pt)
AR (1)	AR064739A1 (pt)
AU (1)	AU2007342364A1 (pt)
BR (1)	BRPI0720323A2 (pt)
CA (1)	CA2674321A1 (pt)
CO (1)	CO6210740A2 (pt)
CR (1)	CR10913A (pt)
EA (1)	EA200900937A1 (pt)
EC (1)	ECSP099538A (pt)
IL (1)	IL199662A0 (pt)
MA (1)	MA31159B1 (pt)
MX (1)	MX2009007209A (pt)
NZ (1)	NZ578290A (pt)
TN (1)	TN2009000278A1 (pt)
WO (1)	WO2008085505A1 (pt)
ZA (1)	ZA200905065B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA200904826B (en)	2007-01-03	2010-09-29	Cortex Pharma Inc	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
JP5694765B2 (ja)	2007-05-17	2015-04-01	コーテックスファーマシューティカルズ，インコーポレイテッド	グルタミン酸作動性シナプス反応を増強するための二置換アミド
US8168632B2 (en)	2007-08-10	2012-05-01	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for the treatment of respiratory disorders
ES2560095T3 (es)	2007-08-10	2016-02-17	Cortex Pharmaceuticals, Inc.	Amidas bicíclicas para mejorar las respuestas sinápticas glutamatérgicas
NZ584098A (en) *	2007-09-20	2012-05-25	Cortex Pharma Inc	3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
US10555916B2 (en)	2013-01-25	2020-02-11	Case Western Reserve University	NMDAR antagonist for the treatment of pervasive development disorders
CN105418525B (zh) *	2015-12-16	2017-12-15	郑州轻工业学院	一种n‑取代1,2,3‑苯并三嗪‑4‑酮的制备方法
CN114716416B (zh) *	2022-04-11	2023-06-16	湖北大学	3,4-二氢吡咯衍生物及其一锅法合成
EP4685143A1 (en) *	2023-03-21	2026-01-28	Vivozon,Inc.	Double regulator for mglur5 and hdac6 and use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3723436A (en) *	1971-02-25	1973-03-27	Sun Oil Co	Process for aromatic lactams
FR2597103B1 (fr) *	1986-04-15	1988-12-16	Provesan Sa	Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
GB9202915D0 (en) *	1992-02-12	1992-03-25	Wellcome Found	Chemical compounds
DE69331761T2 (de) *	1992-07-24	2002-09-12	The Regents Of The University Of California, Oakland	Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
AU4416197A (en) *	1996-09-17	1998-04-14	Regents Of The University Of California, The	Positive ampa receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) *	1997-02-13	2000-08-29	The Regents Of The University Of California	Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) *	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
US6713474B2 (en) *	1998-09-18	2004-03-30	Abbott Gmbh & Co. Kg	Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) *	2000-08-18	2001-10-16	Rohm And Haas Company	Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
WO2003045315A2 (en) *	2001-11-26	2003-06-05	Cortex Pharmaceuticals, Inc.	Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
AUPS255202A0 (en) *	2002-05-27	2002-06-13	Monash University	Agents and methods for the treatment of disorders associated with motor neuron degeneration
DE10238865A1 (de) *	2002-08-24	2004-03-11	Boehringer Ingelheim International Gmbh	Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
GB0317482D0 (en) *	2003-07-25	2003-08-27	Pfizer Ltd	Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) *	2003-10-14	2007-01-17	惠氏公司	稠合芳基和杂芳基衍生物及其使用方法
ZA200904826B (en) *	2007-01-03	2010-09-29	Cortex Pharma Inc	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
JP5694765B2 (ja) *	2007-05-17	2015-04-01	コーテックスファーマシューティカルズ，インコーポレイテッド	グルタミン酸作動性シナプス反応を増強するための二置換アミド
NZ584098A (en) *	2007-09-20	2012-05-25	Cortex Pharma Inc	3-substituted 1,2,3-triazin-4-one's and 3-substituted 1,3-pyrimidinone's for enhancing glutamatergic synaptic responses

2007
- 2007-12-28 CA CA002674321A patent/CA2674321A1/en not_active Abandoned
- 2007-12-28 JP JP2009544856A patent/JP2010514837A/ja active Pending
- 2007-12-28 AU AU2007342364A patent/AU2007342364A1/en not_active Abandoned
- 2007-12-28 BR BRPI0720323A patent/BRPI0720323A2/pt not_active IP Right Cessation
- 2007-12-28 WO PCT/US2007/026415 patent/WO2008085505A1/en not_active Ceased
- 2007-12-28 US US12/448,770 patent/US20100041647A1/en not_active Abandoned
- 2007-12-28 KR KR1020097015941A patent/KR20090098999A/ko not_active Ceased
- 2007-12-28 AP AP2009004915A patent/AP2009004915A0/xx unknown
- 2007-12-28 NZ NZ578290A patent/NZ578290A/en not_active IP Right Cessation
- 2007-12-28 MX MX2009007209A patent/MX2009007209A/es not_active Application Discontinuation
- 2007-12-28 EP EP07868092A patent/EP2114158B1/en active Active
- 2007-12-28 EA EA200900937A patent/EA200900937A1/ru unknown
- 2007-12-28 CN CN200780051958A patent/CN101626686A/zh active Pending
2008
- 2008-01-03 AR ARP080100021A patent/AR064739A1/es not_active Application Discontinuation
2009
- 2009-06-30 TN TNP2009000278A patent/TN2009000278A1/fr unknown
- 2009-07-02 IL IL199662A patent/IL199662A0/en unknown
- 2009-07-03 CR CR10913A patent/CR10913A/es not_active Application Discontinuation
- 2009-07-14 CO CO09072923A patent/CO6210740A2/es not_active Application Discontinuation
- 2009-07-20 ZA ZA200905065A patent/ZA200905065B/xx unknown
- 2009-07-23 EC EC2009009538A patent/ECSP099538A/es unknown
- 2009-07-31 MA MA32133A patent/MA31159B1/fr unknown

Also Published As

Publication number	Publication date
KR20090098999A (ko)	2009-09-18
CO6210740A2 (es)	2010-10-20
EP2114158B1 (en)	2012-08-08
WO2008085505A1 (en)	2008-07-17
IL199662A0 (en)	2010-04-15
ZA200905065B (en)	2010-04-28
MX2009007209A (es)	2009-10-12
EP2114158A4 (en)	2010-05-05
US20100041647A1 (en)	2010-02-18
MA31159B1 (fr)	2010-02-01
JP2010514837A (ja)	2010-05-06
AR064739A1 (es)	2009-04-22
EP2114158A1 (en)	2009-11-11
CN101626686A (zh)	2010-01-13
TN2009000278A1 (en)	2010-10-18
ECSP099538A (es)	2009-12-28
CA2674321A1 (en)	2008-07-17
CR10913A (es)	2009-09-21
AU2007342364A1 (en)	2008-07-17
NZ578290A (en)	2012-03-30
AP2009004915A0 (en)	2009-08-31
EA200900937A1 (ru)	2009-12-30

Legal Events

Date	Code	Title	Description
2016-08-16	B15I	Others concerning applications: loss of priority	Free format text: PERDA DA PRIORIDADE US 60/878,626 DE 03/01/2007, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 7O E NO ART. 28 DO ATO NORMATIVO 128/1997, POR NAO ATENDER AO DISPOSTO NO ART. 27 DO ATO NORMATIVO 128/1997, POIS NAO FOI APRESENTADA CESSAO DA REFERIDA PRIORIDADE, QUE POSSUI DEPOSITANTE DIFERENTE DO DEPOSITANTE DA FASE NACIONAL.
2016-09-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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