CR10986A - 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) - Google Patents

6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Info

Publication number
CR10986A
CR10986A CR10986A CR10986A CR10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A
Authority
CR
Costa Rica
Prior art keywords
penems
alquiliden
divisional
bicycle
lactamases
Prior art date
Application number
CR10986A
Other languages
English (en)
Inventor
Mudumbai Vekatesan Aranapakam
Abe Takao
Mansour Suhayl Tarek
Yamamura Itsuki
Takasaki Tsuyoshi
Santos Dos Osvaldo
Sum Fuk-Wah
Lin Yang-I
Atul Agarwal
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR10986A publication Critical patent/CR10986A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a ciertos 6-alquilidem-penems triciclicos que actuan como inhibidores de B-lactamasa de espectro amplio. Las B-Lactamasas hidrolizan los antibioticos de B-lactamasa y como tales sirven como la causa principal de la resistencia bacteriana. Los compuestos de la invencion, cuando combinan con antibioticos de B-lactama, proporcionaran un tratamiento efectivo contra infecciones bacterianas que atentan contra la vida.
CR10986A 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) CR10986A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
CR10986A true CR10986A (es) 2009-09-09

Family

ID=29401437

Family Applications (3)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)
CR10986A CR10986A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Country Status (21)

Country Link
US (3) US7112582B2 (es)
EP (2) EP1499621A1 (es)
JP (2) JP4602759B2 (es)
KR (1) KR20050007368A (es)
CN (2) CN1649883B (es)
AR (1) AR039774A1 (es)
AU (1) AU2003231205A1 (es)
BR (1) BR0309757A (es)
CA (1) CA2483538A1 (es)
CR (3) CR7508A (es)
EC (1) ECSP045397A (es)
IL (1) IL164899A0 (es)
MX (1) MXPA04010663A (es)
NO (1) NO20044549L (es)
NZ (1) NZ536182A (es)
RU (1) RU2339640C2 (es)
SG (1) SG162614A1 (es)
TW (1) TW200307687A (es)
UA (1) UA79117C2 (es)
WO (1) WO2003093279A1 (es)
ZA (1) ZA200409686B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
MXPA06002125A (es) * 2003-08-25 2006-05-31 Revaax Pharmaceuticals Llc Composiciones orales de cefazolin neuroterapeutico.
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
CA2615886A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
BRPI0613928A2 (pt) * 2005-07-27 2011-02-15 Wyeth Corp método para o tratamento de uma infecção ou doença bacteriana; composição; produto; e uso de cefepima ou de um sal farmaceuticamente aceitável da mesma e um composto de fórmula i ou um sal farmaceuticamente aceitável ou éster hidrolisável in vivo do mesmo
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
US10323042B2 (en) 2016-02-23 2019-06-18 Pfizer Inc. 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
CN108473510B (zh) * 2016-04-28 2021-10-29 豪夫迈·罗氏有限公司 制备2-吡唑并[1,5-a]吡嗪-2-基吡啶并[1,2-a]嘧啶-4-酮的方法
ES2938615T3 (es) 2016-08-15 2023-04-13 Bayer Cropscience Ag Derivados del heterociclo bicíclico condensado como agentes de control de plagas
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
CA3217941A1 (en) * 2021-05-21 2022-11-24 Chengdu Baiyu Pharmaceutical Co., Ltd. Piperazine derivative and use thereof in medicine

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
EP0041768B1 (en) 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (en) 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8402086D0 (en) 1984-01-26 1984-02-29 Beecham Group Plc Compounds
EP0150984B1 (en) 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
EP0167050A1 (en) * 1984-06-21 1986-01-08 Beecham Group Plc Clavulanate compounds, their preparation and use and intermediates thereof
GB8518422D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518421D0 (en) 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3752124T2 (de) 1986-01-17 1998-03-26 Beecham Group Plc Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB8724566D0 (en) 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
GB8729614D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
GB8729613D0 (en) 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
EP0447704A1 (en) 1990-03-21 1991-09-25 Smithkline Beecham Farmaceutici S.p.A. N-Acylated azacyclic compounds, processes for their preparations and their use as medications
GB9116236D0 (en) 1991-07-27 1991-09-11 Smithkline Beecham Plc Novel compounds
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
US5349045A (en) 1993-01-26 1994-09-20 United States Surgical Corporation Polymer derived from cyclic amide and medical devices manufactured therefrom
GB9326248D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
MX9605149A (es) 1994-04-25 1997-12-31 Smithkline Beecham Plc Formulaciones farmaceuticas que contienen una penema inhibidora de beta-lactamasa en combinacion con un antibiotico de beta-lactama y su uso en el tratamiento de infecciones bacterianas.
US5629322A (en) 1994-11-15 1997-05-13 Merck & Co., Inc. Cyclic amidine analogs as inhibitors of nitric oxide synthase
CN1334727A (zh) * 1998-10-15 2002-02-06 萨拉沃克梅迪切姆药品公司 治疗和预防结核病的方法和组合物
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
EP1199077A1 (en) * 2000-10-19 2002-04-24 Amura Limited Stable compositions of oxapenem-3-carboxylic acids by Co-lyophilisation with pharmaceutical carriers
GB0106428D0 (en) * 2001-03-15 2001-05-02 Amura Ltd Antibacterial composition
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
CA2615886A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
ECSP045397A (es) 2005-01-03
KR20050007368A (ko) 2005-01-17
JP4602759B2 (ja) 2010-12-22
RU2004135082A (ru) 2006-01-20
SG162614A1 (en) 2010-07-29
US7812014B2 (en) 2010-10-12
TW200307687A (en) 2003-12-16
NO20044549L (no) 2005-01-25
AR039774A1 (es) 2005-03-02
IL164899A0 (en) 2005-12-18
US7112582B2 (en) 2006-09-26
WO2003093279A1 (en) 2003-11-13
MXPA04010663A (es) 2005-04-20
AU2003231205A1 (en) 2003-11-17
EP1499621A1 (en) 2005-01-26
US20080312203A1 (en) 2008-12-18
US20040077622A1 (en) 2004-04-22
JP2010215652A (ja) 2010-09-30
CN1649883A (zh) 2005-08-03
EP1988093A1 (en) 2008-11-05
CA2483538A1 (en) 2003-11-13
CR7508A (es) 2005-01-05
CN1649883B (zh) 2010-05-26
NZ536182A (en) 2006-10-27
CR10983A (es) 2009-09-09
UA79117C2 (en) 2007-05-25
US20060217361A1 (en) 2006-09-28
JP2005533017A (ja) 2005-11-04
CN101570545A (zh) 2009-11-04
BR0309757A (pt) 2005-03-08
RU2339640C2 (ru) 2008-11-27
ZA200409686B (en) 2007-09-26

Similar Documents

Publication Publication Date Title
CR10986A (es) 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)
ATE461217T1 (de) Glp-1-verbindungen
MXPA05004217A (es) Composiciones novedosas con actividad de quitinasa.
ECSP066893A (es) Inhibidores de proteínas de apoptosis (iap)
DOP2010000218A (es) Inhibidores de beta-lactamasa
EA200501928A1 (ru) Пирролодигидроизохинолины как ингибиторы pde10
CO5600999A2 (es) Composiciones farmaceuticas que comprenden inhibidores de valsartan y endopeptidasa neutra
AU2003274601A1 (en) Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides
WO2004092123A3 (en) Inhibitors of fungal invasion
ITVR20020062A1 (it) Preparazione estemporanea di periossiacidi organici stabili nel tempo
MY162110A (en) Caspase inhibitors containing isoxazoline ring
ECSP044981A (es) Composicion oftalmica que comprende ascomicina
NO20082298L (no) Kaliumkanalinhibitorer
SG149855A1 (en) N-channel transistor
GT200300171A (es) Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
NO20076076L (no) Bicykliske 6-alkyliden-penems som klasse-D beta-laktamase inhibitorer
ECSP055729A (es) Nuevos inhibidores biciclicos de la lipasa sensible a hormonas
UA91204C2 (ru) Композиция для преодоления опосредствованной бета-лактамазой резистентности к антибиотикам с использованием ингибитора бета-лактамазы, предназначенная для инъекции
AU2003228796A1 (en) Cholinesterase inhibitors to prevent injuries caused by chemicals
ATE549024T1 (de) Chinazolin-kaliumkanalhemmer
CR7512A (es) Procedimiento para preparar derivados de 6-alquiliden-penem
PA8567201A1 (es) Combinaciones de un ligando alfa-2-delta con un inhibidor selectivo de la cicloxigenasa-2
CR8341A (es) Una composicion y metodo de tratamiento para condiciones urogenitales
SG145685A1 (en) Matrix metalloproteinase inhibitors
ATE410925T1 (de) Antibakterielle zusammensetzung

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)