CR10986A - 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) - Google Patents

6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Info

Publication number
CR10986A
CR10986A CR10986A CR10986A CR10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A CR 10986 A CR10986 A CR 10986A
Authority
CR
Costa Rica
Prior art keywords
penems
alquiliden
divisional
bicycle
lactamases
Prior art date
Application number
CR10986A
Other languages
English (en)
Inventor
Mudumbai Vekatesan Aranapakam
Abe Takao
Mansour Suhayl Tarek
Yamamura Itsuki
Takasaki Tsuyoshi
Santos Dos Osvaldo
Sum Fuk-Wah
Lin Yang-I
Atul Agarwal
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR10986A publication Critical patent/CR10986A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/881—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrogen atom or an unsubstituted hydrocarbon radical, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a ciertos 6-alquilidem-penems triciclicos que actuan como inhibidores de B-lactamasa de espectro amplio. Las B-Lactamasas hidrolizan los antibioticos de B-lactamasa y como tales sirven como la causa principal de la resistencia bacteriana. Los compuestos de la invencion, cuando combinan con antibioticos de B-lactama, proporcionaran un tratamiento efectivo contra infecciones bacterianas que atentan contra la vida.
CR10986A 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional) CR10986A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37705202P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
CR10986A true CR10986A (es) 2009-09-09

Family

ID=29401437

Family Applications (3)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas
CR10986A CR10986A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR7508A CR7508A (es) 2002-05-01 2004-10-06 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR10983A CR10983A (es) 2002-05-01 2009-08-21 6-alquiliden-penems biciclicos como inhibidores de b-lactamasas (divisional)

Country Status (21)

Country Link
US (3) US7112582B2 (es)
EP (2) EP1988093A1 (es)
JP (2) JP4602759B2 (es)
KR (1) KR20050007368A (es)
CN (2) CN101570545A (es)
AR (1) AR039774A1 (es)
AU (1) AU2003231205A1 (es)
BR (1) BR0309757A (es)
CA (1) CA2483538A1 (es)
CR (3) CR7508A (es)
EC (1) ECSP045397A (es)
IL (1) IL164899A0 (es)
MX (1) MXPA04010663A (es)
NO (1) NO20044549L (es)
NZ (1) NZ536182A (es)
RU (1) RU2339640C2 (es)
SG (1) SG162614A1 (es)
TW (1) TW200307687A (es)
UA (1) UA79117C2 (es)
WO (1) WO2003093279A1 (es)
ZA (1) ZA200409686B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
MXPA06002125A (es) * 2003-08-25 2006-05-31 Revaax Pharmaceuticals Llc Composiciones orales de cefazolin neuroterapeutico.
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
AU2006275940A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
TW200738235A (en) * 2005-07-27 2007-10-16 Wyeth Corp Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa
US20090018332A1 (en) * 2007-06-28 2009-01-15 Wyeth Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors
CN104119857A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
CN104119858A (zh) * 2013-04-27 2014-10-29 海洋王照明科技股份有限公司 一种铱金属配合物有机电致磷光材料及其制备方法和有机电致发光器件
PL3419979T3 (pl) 2016-02-23 2020-06-29 Pfizer Inc. Związki 6,7-dihydro-5h-pirazolo[5,1-b][1,3]oksazyno-2- karboksyamidowe
WO2017186668A1 (en) * 2016-04-28 2017-11-02 F. Hoffmann-La Roche Ag A process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one
EP3497102B1 (de) 2016-08-15 2022-12-07 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
CN114957258A (zh) * 2021-02-25 2022-08-30 华东理工大学 基于碳青霉烯结构的广谱丝氨酸β-内酰胺酶抑制剂的合成及其在耐药细菌抑制中的应用
KR20240012534A (ko) * 2021-05-21 2024-01-29 청두 바이위 파머수티컬 씨오., 엘티디 피페라진 유도체 및 이의 의학적 용도

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EP0041768B1 (en) 1980-04-24 1987-11-11 Beecham Group Plc Beta-lactam compounds, their preparation and use
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FI82471C (fi) 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
EP0150984B1 (en) 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
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AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
AU2006275940A1 (en) * 2005-07-27 2007-02-08 Wyeth Bicyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic

Also Published As

Publication number Publication date
TW200307687A (en) 2003-12-16
MXPA04010663A (es) 2005-04-20
CN101570545A (zh) 2009-11-04
CN1649883B (zh) 2010-05-26
JP2010215652A (ja) 2010-09-30
US7112582B2 (en) 2006-09-26
RU2339640C2 (ru) 2008-11-27
ECSP045397A (es) 2005-01-03
AR039774A1 (es) 2005-03-02
RU2004135082A (ru) 2006-01-20
IL164899A0 (en) 2005-12-18
EP1988093A1 (en) 2008-11-05
AU2003231205A1 (en) 2003-11-17
US20080312203A1 (en) 2008-12-18
BR0309757A (pt) 2005-03-08
ZA200409686B (en) 2007-09-26
JP4602759B2 (ja) 2010-12-22
JP2005533017A (ja) 2005-11-04
WO2003093279A1 (en) 2003-11-13
US7812014B2 (en) 2010-10-12
EP1499621A1 (en) 2005-01-26
CR10983A (es) 2009-09-09
SG162614A1 (en) 2010-07-29
NO20044549L (no) 2005-01-25
CA2483538A1 (en) 2003-11-13
KR20050007368A (ko) 2005-01-17
CN1649883A (zh) 2005-08-03
UA79117C2 (en) 2007-05-25
US20040077622A1 (en) 2004-04-22
NZ536182A (en) 2006-10-27
CR7508A (es) 2005-01-05
US20060217361A1 (en) 2006-09-28

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)