CR11601A - Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa - Google Patents

Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa

Info

Publication number
CR11601A
CR11601A CR11601A CR11601A CR11601A CR 11601 A CR11601 A CR 11601A CR 11601 A CR11601 A CR 11601A CR 11601 A CR11601 A CR 11601A CR 11601 A CR11601 A CR 11601A
Authority
CR
Costa Rica
Prior art keywords
pyrimidil
quinasa
cyclopentanes
proteina
akt
Prior art date
Application number
CR11601A
Other languages
English (en)
Inventor
Josef R Bencsik
James F Blake
Nicholas C Kallan
Ian S Mitchell
Keith Lee Spencer
Dengming Xiao
Rui Xu
Christine Chabot
Steven Do
Jun Liang
Brian Safina
Birong Zhang
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of CR11601A publication Critical patent/CR11601A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion provee compuestos, que incluyen sales aceptables para uso farmaceutico, que comprenden la formula I.
CR11601A 2008-01-09 2010-07-27 Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa CR11601A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2009208P 2008-01-09 2008-01-09

Publications (1)

Publication Number Publication Date
CR11601A true CR11601A (es) 2010-08-19

Family

ID=40552865

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11601A CR11601A (es) 2008-01-09 2010-07-27 Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteina quinasa

Country Status (18)

Country Link
US (1) US8835434B2 (es)
EP (1) EP2247578B1 (es)
JP (1) JP5346345B2 (es)
KR (1) KR101624753B1 (es)
CN (1) CN101932564B (es)
AU (1) AU2009204025B2 (es)
BR (1) BRPI0906798A2 (es)
CA (1) CA2711699A1 (es)
CR (1) CR11601A (es)
EC (1) ECSP10010389A (es)
ES (1) ES2422733T3 (es)
IL (1) IL206575A0 (es)
MA (1) MA32183B1 (es)
NZ (1) NZ586346A (es)
RU (1) RU2504542C2 (es)
UA (1) UA100545C2 (es)
WO (1) WO2009089459A1 (es)
ZA (1) ZA201004769B (es)

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US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
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CA2711782C (en) 2008-01-09 2017-01-03 Array Biopharma Inc. 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors
ES2392014T3 (es) 2008-01-09 2012-12-03 Array Biopharma, Inc. Pirazolopiridinas como inhibidores de la cinasa
DK2861583T3 (en) * 2012-05-17 2016-10-03 Array Biopharma Inc METHOD OF PRODUCING hydroxylated CYCLOPENTYLPYRIMIDINFORBINDELSER
RS60417B9 (sr) * 2012-05-17 2021-07-30 Genentech Inc Amorfni oblik aktivnog jedinjenja koje inhibira pirimidinil-ciklopentansko jedinjenje, smeše i njegove metode
SG10201901578UA (en) 2013-11-15 2019-03-28 Hoffmann La Roche Processes for the preparation of pyrimidinylcyclopentane compounds

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Also Published As

Publication number Publication date
ES2422733T3 (es) 2013-09-13
UA100545C2 (ru) 2013-01-10
ECSP10010389A (es) 2010-11-30
MA32183B1 (fr) 2011-04-01
JP5346345B2 (ja) 2013-11-20
RU2504542C2 (ru) 2014-01-20
JP2011509308A (ja) 2011-03-24
KR101624753B1 (ko) 2016-05-26
BRPI0906798A2 (pt) 2015-07-14
AU2009204025B2 (en) 2014-02-20
WO2009089459A1 (en) 2009-07-16
ZA201004769B (en) 2011-12-28
AU2009204025A1 (en) 2009-07-16
IL206575A0 (en) 2010-12-30
RU2010132911A (ru) 2012-02-20
CN101932564B (zh) 2012-12-26
NZ586346A (en) 2012-02-24
US8835434B2 (en) 2014-09-16
CA2711699A1 (en) 2009-07-16
CN101932564A (zh) 2010-12-29
US20110065716A1 (en) 2011-03-17
EP2247578A1 (en) 2010-11-10
EP2247578B1 (en) 2013-05-22
KR20100118110A (ko) 2010-11-04

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