CR11742A - Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6 - Google Patents

Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6

Info

Publication number
CR11742A
CR11742A CR11742A CR11742A CR11742A CR 11742 A CR11742 A CR 11742A CR 11742 A CR11742 A CR 11742A CR 11742 A CR11742 A CR 11742A CR 11742 A CR11742 A CR 11742A
Authority
CR
Costa Rica
Prior art keywords
antagonists
pirazolin
arilsulfonil
carboxamidine derivatives
carboxamidine
Prior art date
Application number
CR11742A
Other languages
English (en)
Inventor
Loevezijn Arnold Van
Bakker Wonter I Iwema
Axel Stoit
Agatha A M Rensink
Jennifer Venhorst
Der Neut Martina A W Van
Haan Martin De
Cornelis G Kruse
Original Assignee
Abbott Healthcare Products Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Healthcare Products Bv filed Critical Abbott Healthcare Products Bv
Publication of CR11742A publication Critical patent/CR11742A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-HT6, a métodos para la preparación de estos compuestos y a novedosos intermediarios útiles para su sintesis.
CR11742A 2008-03-18 2010-10-15 Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6 CR11742A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3746308P 2008-03-18 2008-03-18
EP08152873 2008-03-18

Publications (1)

Publication Number Publication Date
CR11742A true CR11742A (es) 2011-03-03

Family

ID=39639064

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11742A CR11742A (es) 2008-03-18 2010-10-15 Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6

Country Status (29)

Country Link
US (3) US8563723B2 (es)
EP (2) EP2610247B1 (es)
JP (1) JP5504252B2 (es)
KR (1) KR101623357B1 (es)
CN (2) CN102036967B (es)
AR (1) AR070898A1 (es)
AU (1) AU2009226956C1 (es)
BR (1) BRPI0908738A8 (es)
CA (1) CA2717922A1 (es)
CO (1) CO6290679A2 (es)
CR (1) CR11742A (es)
DK (2) DK2265589T3 (es)
DO (2) DOP2010000276A (es)
EA (1) EA023176B1 (es)
EC (1) ECSP10010476A (es)
ES (2) ES2577867T3 (es)
HK (1) HK1201823A1 (es)
IL (1) IL207846A0 (es)
MX (1) MX2010010299A (es)
MY (1) MY155318A (es)
NZ (1) NZ587743A (es)
PH (1) PH12013502376A1 (es)
PL (2) PL2610247T3 (es)
PT (1) PT2610247T (es)
SG (1) SG183688A1 (es)
TW (1) TWI557110B (es)
UA (1) UA105629C2 (es)
WO (1) WO2009115515A1 (es)
ZA (1) ZA201006272B (es)

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AR079935A1 (es) 2010-01-29 2012-02-29 Abbott Healthcare Products Bv Sintesis de derivados de pirazolin carboxamidina sustituida
MX356486B (es) * 2011-08-15 2018-05-30 Univ Utah Res Found Análogos sustituidos de la (e)-n' -(1-feniletiliden)benzohidrazida como inhibidores de la histona desmetilasa.
TW201427971A (zh) * 2012-11-16 2014-07-16 必治妥美雅史谷比公司 二氫吡唑ｇｐｒ４０調節劑
AU2013344602A1 (en) 2012-11-16 2015-07-02 Bristol-Myers Squibb Company Dihydropyrazole GPR40 modulators
JP6322204B2 (ja) * 2012-11-16 2018-05-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ジヒドロピラゾールのｇｐｒ４０モジュレーター
AU2015255765A1 (en) * 2014-05-09 2016-11-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
CA2957566C (en) 2014-08-12 2023-08-01 Daniel Paul Becker Indoline sulfonamide inhibitors of dape and ndm-1 and use of the same
EP3109237A1 (en) * 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN107460160A (zh) * 2017-08-23 2017-12-12 世贸天阶制药（江苏）有限责任公司 一种cho细胞无血清培养基
US10879709B2 (en) 2018-05-31 2020-12-29 National Taipei University Of Technology Power management system and operating method thereof
AU2020363864A1 (en) 2019-10-09 2022-04-21 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
CA3185968A1 (en) 2020-07-13 2022-01-20 Tony Lahoutte Antibody fragment against folr1
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
KR20250034289A (ko) 2022-05-02 2025-03-11 프리시릭스 엔.브이. 사전 표적화

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
JP4313672B2 (ja) * 2001-09-21 2009-08-12 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 強力なｃｂ１−拮抗活性を有する４，５−ジヒドロ−１ｈ−ピラゾール誘導体
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
AR062907A1 (es) * 2006-09-22 2008-12-17 Solvay Pharm Bv Derivados de sulfonilpirazol y sulfonilpirazolincarboxamidina como antagonistas de 5-ht6

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AU2009226956A1 (en) 2009-09-24
CN102036967B (zh) 2014-10-15
PT2610247T (pt) 2016-07-07
MX2010010299A (es) 2010-12-15
EP2265589B1 (en) 2016-01-27
AU2009226956A8 (en) 2010-09-23
US20140011775A1 (en) 2014-01-09
ES2577867T3 (es) 2016-07-19
TWI557110B (zh) 2016-11-11
KR20100136504A (ko) 2010-12-28
ZA201006272B (en) 2011-05-25
JP2011517443A (ja) 2011-06-09
US20150051239A1 (en) 2015-02-19
UA105629C2 (uk) 2014-06-10
KR101623357B1 (ko) 2016-05-23
MY155318A (en) 2015-09-30
AR070898A1 (es) 2010-05-12
HK1152708A1 (en) 2012-03-09
AU2009226956B2 (en) 2013-05-23
SG183688A1 (en) 2012-09-27
DK2265589T3 (en) 2016-03-21
EP2265589A1 (en) 2010-12-29
WO2009115515A1 (en) 2009-09-24
IL207846A0 (en) 2010-12-30
ES2565184T3 (es) 2016-04-01
BRPI0908738A8 (pt) 2017-10-10
DOP2010000277A (es) 2011-01-31
TW200942519A (en) 2009-10-16
US9126942B2 (en) 2015-09-08
CN102036967A (zh) 2011-04-27
PL2265589T3 (pl) 2016-06-30
DOP2010000276A (es) 2010-11-15
DK2610247T3 (en) 2016-06-13
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US8563723B2 (en) 2013-10-22
CO6290679A2 (es) 2011-06-20
US20110046171A1 (en) 2011-02-24
BRPI0908738A2 (pt) 2017-06-13
EA023176B1 (ru) 2016-05-31
EP2610247B1 (en) 2016-05-25
HK1201823A1 (en) 2015-09-11
ECSP10010476A (es) 2010-10-30
EA201071083A1 (ru) 2011-04-29
CA2717922A1 (en) 2009-09-24
AU2009226956C1 (en) 2014-03-06
US8901108B2 (en) 2014-12-02
PH12013502376B1 (en) 2015-01-12
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PH12013502376A1 (en) 2015-01-12

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