ECSP10010476A - Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6 - Google Patents
Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6Info
- Publication number
- ECSP10010476A ECSP10010476A EC2010010476A ECSP10010476A ECSP10010476A EC SP10010476 A ECSP10010476 A EC SP10010476A EC 2010010476 A EC2010010476 A EC 2010010476A EC SP10010476 A ECSP10010476 A EC SP10010476A EC SP10010476 A ECSP10010476 A EC SP10010476A
- Authority
- EC
- Ecuador
- Prior art keywords
- disorders
- compounds
- disorder
- disease
- attention deficit
- Prior art date
Links
- 229940124801 5-HT6 antagonist Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 abstract 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 208000032841 Bulimia Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000007000 age related cognitive decline Effects 0.000 abstract 1
- 208000022531 anorexia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- -1 arylsulfonyl pyrazolin carboxamidine derivatives Chemical class 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 208000014679 binge eating disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 abstract 1
- 208000003906 hydrocephalus Diseases 0.000 abstract 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- C07D491/10—Spiro-condensed systems
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- Anesthesiology (AREA)
- Nutrition Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
Esta invención se refiere a derivados de arilsulfonil pirazolin carboxamidina como antagonistas de receptores 5-HT6, a métodos para la preparación de estos compuestos y a novedosos intermediarios útiles para su síntesis. La invención también se refiere a los usos de tales compuestos y composiciones particularmente su uso en la administración de los mismos a pacientes para lograr un efecto terapéutico en la enfermedad de Parkinson, corea de Huntington, esquizofrenia, ansiedad, depresión, depresión maníaca, psicosis, epilepsia, trastornos obsesivos compulsivos, trastornos del ánimo, migraña, enfermedad de Alzheimer, declinación cognitiva relacionada con la edad, deterioro cognitivo leve, trastornos del sueño, trastornos de la alimentación, anorexia, bulimia, trastornos de atracones en la alimentación , ataques de pánico, acatisia, trastorno de hiperactividad y déficit de atención, trastorno de déficit de atención, abstinencia del abuso de cocaína, etanol, nicotina o benzodiazepinas, dolor, trastornos asociados con trauma espinal o daño en la cabeza, hidrocefalia, trastorno funcional del intestino, Síndrome de Intestino Irritable, obesidad y diabetes tipo 2. Los compuestos tienen la fórmula general (1): en donde los símbolos tienen los significados dados en la descripción.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3746308P | 2008-03-18 | 2008-03-18 | |
| EP08152873 | 2008-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010476A true ECSP10010476A (es) | 2010-10-30 |
Family
ID=39639064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010476A ECSP10010476A (es) | 2008-03-18 | 2010-09-13 | Derivados de arilsulfonil pirazolin carboxamidina como antagonistas de 5-ht6 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8563723B2 (es) |
| EP (2) | EP2265589B1 (es) |
| JP (1) | JP5504252B2 (es) |
| KR (1) | KR101623357B1 (es) |
| CN (2) | CN104003937A (es) |
| AR (1) | AR070898A1 (es) |
| AU (1) | AU2009226956C1 (es) |
| BR (1) | BRPI0908738A8 (es) |
| CA (1) | CA2717922A1 (es) |
| CO (1) | CO6290679A2 (es) |
| CR (1) | CR11742A (es) |
| DK (2) | DK2610247T3 (es) |
| DO (2) | DOP2010000276A (es) |
| EA (1) | EA023176B1 (es) |
| EC (1) | ECSP10010476A (es) |
| ES (2) | ES2577867T3 (es) |
| HK (1) | HK1201823A1 (es) |
| IL (1) | IL207846A0 (es) |
| MX (1) | MX2010010299A (es) |
| MY (1) | MY155318A (es) |
| NZ (1) | NZ587743A (es) |
| PH (1) | PH12013502376A1 (es) |
| PL (2) | PL2265589T3 (es) |
| PT (1) | PT2610247T (es) |
| SG (1) | SG183688A1 (es) |
| TW (1) | TWI557110B (es) |
| UA (1) | UA105629C2 (es) |
| WO (1) | WO2009115515A1 (es) |
| ZA (1) | ZA201006272B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR079935A1 (es) * | 2010-01-29 | 2012-02-29 | Abbott Healthcare Products Bv | Sintesis de derivados de pirazolin carboxamidina sustituida |
| SG2014009609A (en) * | 2011-08-15 | 2014-05-29 | Univ Utah Res Found | Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors |
| HUE032401T2 (en) * | 2012-11-16 | 2017-09-28 | Bristol Myers Squibb Co | Dihydropyrazole GPR40 modulators |
| US9656963B2 (en) * | 2012-11-16 | 2017-05-23 | Bristol-Myers Squibb Company | Dihydropyrazole GPR40 modulators |
| KR20150082618A (ko) | 2012-11-16 | 2015-07-15 | 브리스톨-마이어스 스큅 컴퍼니 | 디히드로피라졸 gpr40 조절제 |
| CN106660968B (zh) * | 2014-05-09 | 2020-02-07 | 美国政府(由卫生和人类服务部的部长所代表) | 吡唑衍生物及其作为大麻素受体介体的用途 |
| EP3180312B1 (en) | 2014-08-12 | 2019-10-16 | Loyola University Of Chicago | Indoline sulfonamide inhibitors of dape and ndm-1 and use of the same |
| EP3109237A1 (en) * | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
| CN107460160A (zh) * | 2017-08-23 | 2017-12-12 | 世贸天阶制药（江苏）有限责任公司 | 一种cho细胞无血清培养基 |
| US10879709B2 (en) | 2018-05-31 | 2020-12-29 | National Taipei University Of Technology | Power management system and operating method thereof |
| EP4041393B1 (en) | 2019-10-09 | 2026-04-08 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| WO2022013225A1 (en) | 2020-07-13 | 2022-01-20 | Precirix N.V. | Antibody fragment against folr1 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6974810B2 (en) * | 2001-09-21 | 2005-12-13 | Solvay Pharmaceuticals B.V. | 4,5-Dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity |
| GB0422263D0 (en) | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
| TWI428334B (zh) * | 2006-09-22 | 2014-03-01 | Abbvie Bahamas Ltd | 作為５-ｈｔ6拮抗劑之磺醯基吡唑及磺醯基吡唑啉的甲脒衍生物 |
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