CR11793A - 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas - Google Patents

2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas

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Publication number
CR11793A
CR11793A CR11793A CR11793A CR11793A CR 11793 A CR11793 A CR 11793A CR 11793 A CR11793 A CR 11793A CR 11793 A CR11793 A CR 11793A CR 11793 A CR11793 A CR 11793A
Authority
CR
Costa Rica
Prior art keywords
syk
inhibitors
compounds
kinasas
carboxamids
Prior art date
Application number
CR11793A
Other languages
English (en)
Inventor
J Jia Zhaozhong
Venkataramani Chanddrasekar
Huang Wolin
Mehrotra Mukund
Song Yonghong
M Bauer Shawn
Kane Brian
W Rose Jack
Xu Qing
Anjali Pandey
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of CR11793A publication Critical patent/CR11793A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención está dirigida a compuestos de fórmula I-V y tautómeros correspondientes o sales farmacéuticamente aceptadas, ésteres y profármacos correspondientes que actúan como inhibidores de quinasa syk. La presente invención también está dirigida a intermediarios utilizados en la elaboración de dichos compuestos, la preparación de dichos compuestos, composiciones farmacéuticas que contienen dichos compuestos, métodos para inhibir la activada de quinasa syk.
CR11793A 2008-04-16 2010-11-15 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas CR11793A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4549908P 2008-04-16 2008-04-16
US4540608P 2008-04-16 2008-04-16
US12034808P 2008-12-05 2008-12-05
US12034608P 2008-12-05 2008-12-05

Publications (1)

Publication Number Publication Date
CR11793A true CR11793A (es) 2011-03-07

Family

ID=40793266

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11793A CR11793A (es) 2008-04-16 2010-11-15 2,6-diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o jak quinasas

Country Status (13)

Country Link
EP (1) EP2323993B1 (es)
JP (2) JP5802127B2 (es)
KR (3) KR20100132550A (es)
CN (2) CN102066339B (es)
CA (1) CA2728893C (es)
CR (1) CR11793A (es)
DO (1) DOP2010000309A (es)
MA (1) MA32442B1 (es)
MX (1) MX315135B (es)
SG (2) SG165655A1 (es)
SV (1) SV2010003705A (es)
VN (1) VN29259A1 (es)
WO (1) WO2009136995A2 (es)

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