CR11814A - Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica - Google Patents

Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica

Info

Publication number
CR11814A
CR11814A CR11814A CR11814A CR11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A CR 11814 A CR11814 A CR 11814A
Authority
CR
Costa Rica
Prior art keywords
azacarbolinas
derivatives
preparation
therapeutic use
optionally substituted
Prior art date
Application number
CR11814A
Other languages
English (en)
Spanish (es)
Inventor
Arendt Christopher
Babin Didier
Bedel Olivier
Gouyon Thierry
Levit Mikhail
Mignani Serge
Moorcroft Neil
Papin David
Li Ronghua
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR11814A publication Critical patent/CR11814A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
CR11814A 2008-06-12 2010-11-25 Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica CR11814A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803262 2008-06-12

Publications (1)

Publication Number Publication Date
CR11814A true CR11814A (es) 2011-01-10

Family

ID=40445526

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11814A CR11814A (es) 2008-06-12 2010-11-25 Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica

Country Status (26)

Country Link
US (1) US20110178053A1 (fr)
EP (1) EP2303882A2 (fr)
JP (1) JP2011522867A (fr)
KR (1) KR20110016998A (fr)
CN (1) CN102124007A (fr)
AR (1) AR072084A1 (fr)
AU (1) AU2009259114B2 (fr)
BR (1) BRPI0915204A2 (fr)
CA (1) CA2725093A1 (fr)
CO (1) CO6280536A2 (fr)
CR (1) CR11814A (fr)
DO (1) DOP2010000366A (fr)
EA (1) EA018945B1 (fr)
EC (1) ECSP10010670A (fr)
IL (1) IL209840A0 (fr)
MA (1) MA32460B1 (fr)
MX (1) MX2010013699A (fr)
NI (1) NI201000210A (fr)
NZ (1) NZ589839A (fr)
PE (1) PE20110122A1 (fr)
SV (1) SV2010003754A (fr)
TW (1) TW201002711A (fr)
UA (1) UA101668C2 (fr)
UY (1) UY31895A (fr)
WO (1) WO2009150381A2 (fr)
ZA (1) ZA201008387B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009151598A1 (fr) * 2008-06-11 2009-12-17 Genentech, Inc. Diazacarbazoles et procédés d’utilisation
CN102118969B (zh) 2008-06-12 2017-03-08 詹森药业有限公司 组胺h4受体的二氨基吡啶、二氨基嘧啶和二氨基哒嗪调节剂
CN102365282A (zh) * 2009-03-24 2012-02-29 赛诺菲 9H-吡咯并[2，3-b：5，4-c’]二吡啶氮杂咔啉衍生物、其制备方法及其治疗用途
FR2950891B1 (fr) * 2009-10-06 2012-11-09 Sanofi Aventis Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
FR2953838B1 (fr) * 2009-12-10 2012-02-24 Sanofi Aventis Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) * 2009-12-16 2011-07-28 Genentech, Inc. 1,7-diazacarbazoles and methods of use
US9611267B2 (en) 2012-06-13 2017-04-04 Incyte Holdings Corporation Substituted tricyclic compounds as FGFR inhibitors
EP2970312B1 (fr) * 2013-03-11 2017-11-15 The Regents of The University of Michigan Inhibiteurs de bromodomaines bet et méthodes thérapeutiques les utilisant
KR101612179B1 (ko) * 2013-04-19 2016-04-12 영남대학교 산학협력단 아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 암질환 예방 또는 치료용 약학조성물
CN103408573B (zh) * 2013-07-12 2015-12-23 上海工程技术大学 硼酸衍生物及其制备方法和应用
WO2018137655A1 (fr) * 2017-01-25 2018-08-02 江苏豪森药业集团有限公司 Dérivé de pyrrolo-pyridine n-oxyde, son procédé de préparation et son utilisation
KR102700664B1 (ko) * 2017-08-07 2024-08-29 조인트 스탁 컴퍼니 “바이오케드” Cdk8/19 저해제로서 새로운 헤테로사이클릭 화합물
TW201946630A (zh) 2018-05-04 2019-12-16 美商英塞特公司 Fgfr抑制劑之鹽
ES2991427T3 (es) 2018-05-04 2024-12-03 Incyte Corp Formas sólidas de un inhibidor de FGFR y procedimientos para preparar las mismas
WO2020072675A1 (fr) 2018-10-02 2020-04-09 Northwestern University Bêta-carbolines servant de modulateurs allostériques positifs du récepteur humain de la sérotonine 2c (5-ht2c)
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2009151598A1 (fr) * 2008-06-11 2009-12-17 Genentech, Inc. Diazacarbazoles et procédés d’utilisation

Also Published As

Publication number Publication date
BRPI0915204A2 (pt) 2019-01-15
EA018945B1 (ru) 2013-11-29
KR20110016998A (ko) 2011-02-18
PE20110122A1 (es) 2011-03-07
WO2009150381A2 (fr) 2009-12-17
CN102124007A (zh) 2011-07-13
NI201000210A (es) 2011-05-09
TW201002711A (en) 2010-01-16
UA101668C2 (ru) 2013-04-25
MA32460B1 (fr) 2011-07-03
WO2009150381A3 (fr) 2010-02-18
JP2011522867A (ja) 2011-08-04
EA201170002A1 (ru) 2011-08-30
MX2010013699A (es) 2011-02-23
CO6280536A2 (es) 2011-05-20
AU2009259114A1 (en) 2009-12-17
ZA201008387B (en) 2012-02-29
ECSP10010670A (es) 2011-01-31
EP2303882A2 (fr) 2011-04-06
IL209840A0 (en) 2011-02-28
US20110178053A1 (en) 2011-07-21
AR072084A1 (es) 2010-08-04
CA2725093A1 (fr) 2009-12-17
DOP2010000366A (es) 2010-12-31
AU2009259114B2 (en) 2013-05-23
UY31895A (es) 2010-01-29
SV2010003754A (es) 2011-03-15
NZ589839A (en) 2012-07-27

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)