CR11814A - Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica - Google Patents

Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica

Info

Publication number: CR11814A
Authority: CR; Costa Rica
Prior art keywords: azacarbolinas; derivatives; preparation; therapeutic use; optionally substituted
Prior art date: 2008-06-12

Application number

CR11814A

Other languages

English (en)

Spanish (es)

Inventor

Arendt Christopher

Babin Didier

Bedel Olivier

Gouyon Thierry

Levit Mikhail

Mignani Serge

Moorcroft Neil

Papin David

Li Ronghua

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-12

Filing date

2010-11-25

Publication date

2011-01-10

2010-11-25 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-01-10 Publication of CR11814A publication Critical patent/CR11814A/es

Links

230000001225 therapeutic effect Effects 0.000 title 1
150000001408 amides Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

CR11814A 2008-06-12 2010-11-25 Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica CR11814A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0803262		2008-06-12

Publications (1)

Publication Number	Publication Date
CR11814A true CR11814A (es)	2011-01-10

Family

ID=40445526

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CR11814A CR11814A (es)	2008-06-12	2010-11-25	Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica

Country Status (26)

Country	Link
US (1)	US20110178053A1 (fr)
EP (1)	EP2303882A2 (fr)
JP (1)	JP2011522867A (fr)
KR (1)	KR20110016998A (fr)
CN (1)	CN102124007A (fr)
AR (1)	AR072084A1 (fr)
AU (1)	AU2009259114B2 (fr)
BR (1)	BRPI0915204A2 (fr)
CA (1)	CA2725093A1 (fr)
CO (1)	CO6280536A2 (fr)
CR (1)	CR11814A (fr)
DO (1)	DOP2010000366A (fr)
EA (1)	EA018945B1 (fr)
EC (1)	ECSP10010670A (fr)
IL (1)	IL209840A0 (fr)
MA (1)	MA32460B1 (fr)
MX (1)	MX2010013699A (fr)
NI (1)	NI201000210A (fr)
NZ (1)	NZ589839A (fr)
PE (1)	PE20110122A1 (fr)
SV (1)	SV2010003754A (fr)
TW (1)	TW201002711A (fr)
UA (1)	UA101668C2 (fr)
UY (1)	UY31895A (fr)
WO (1)	WO2009150381A2 (fr)
ZA (1)	ZA201008387B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI466886B (zh)	2008-06-11	2015-01-01	Genentech Inc	二氮雜咔唑及使用方法
MX2010013726A (es)	2008-06-12	2011-01-14	Janssen Pharmaceutica Nv	Moduladores de diamino-piridina, pirimidina, y piridazina del receptor h4 de histamina.
FR2950891B1 (fr) *	2009-10-06	2012-11-09	Sanofi Aventis	Derives d'azacarbolines 9h-pyrrolo[2,3-b:5,4-c']dipyridine, leur preparation et leur utilisation therapeutique
AR073431A1 (es) *	2009-03-24	2010-11-03	Sanofi Aventis	Derivados de azacarbolinas 9h- pirrolo (2,3-b:5,4-c) dipiridina , su preparacion y si utilizacion terapeutica
FR2953838B1 (fr) *	2009-12-10	2012-02-24	Sanofi Aventis	Derives de 9h-beta-carboline (ou 9h-pyridino[3,4-b]indole) trisubstitues, leur preparation et leur utilisation therapeutique
US20110183938A1 (en) *	2009-12-16	2011-07-28	Genentech, Inc.	1,7-diazacarbazoles and methods of use
RS58514B1 (sr)	2012-06-13	2019-04-30	Incyte Holdings Corp	Supstituisana triciklična jedinjenja kao inhibitori fgfr
EP2970312B1 (fr) *	2013-03-11	2017-11-15	The Regents of The University of Michigan	Inhibiteurs de bromodomaines bet et méthodes thérapeutiques les utilisant
KR101663864B1 (ko) *	2013-04-19	2016-10-07	영남대학교 산학협력단	아미도피리딘올 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 약학조성물
CN103408573B (zh) *	2013-07-12	2015-12-23	上海工程技术大学	硼酸衍生物及其制备方法和应用
CN110198941B (zh) *	2017-01-25	2021-09-28	江苏豪森药业集团有限公司	吡咯并吡啶类n-氧化衍生物及其制备方法和应用
JP7365332B2 (ja) *	2017-08-07	2023-10-19	ジョイント・ストック・カンパニー “バイオキャド”	Ｃｄｋ８／１９阻害薬としての新規ヘテロ環式化合物
HRP20241288T1 (hr)	2018-05-04	2024-12-06	Incyte Corporation	Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju
AU2019262579B2 (en)	2018-05-04	2024-09-12	Incyte Corporation	Salts of an FGFR inhibitor
WO2020072675A1 (fr)	2018-10-02	2020-04-09	Northwestern University	Bêta-carbolines servant de modulateurs allostériques positifs du récepteur humain de la sérotonine 2c (5-ht2c)
JP7832891B2 (ja)	2019-12-04	2026-03-18	インサイト・コーポレイション	Ｆｇｆｒ阻害剤の誘導体
CN116693449A (zh)	2022-03-04	2023-09-05	上海致根医药科技有限公司	用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
TWI466886B (zh) *	2008-06-11	2015-01-01	Genentech Inc	二氮雜咔唑及使用方法

2009
- 2009-06-10 AR ARP090102077A patent/AR072084A1/es not_active Application Discontinuation
- 2009-06-11 US US12/997,326 patent/US20110178053A1/en not_active Abandoned
- 2009-06-11 EP EP09761932A patent/EP2303882A2/fr not_active Withdrawn
- 2009-06-11 CA CA2725093A patent/CA2725093A1/fr not_active Abandoned
- 2009-06-11 JP JP2011513034A patent/JP2011522867A/ja not_active Ceased
- 2009-06-11 MX MX2010013699A patent/MX2010013699A/es active IP Right Grant
- 2009-06-11 EA EA201170002A patent/EA018945B1/ru not_active IP Right Cessation
- 2009-06-11 BR BRPI0915204A patent/BRPI0915204A2/pt not_active IP Right Cessation
- 2009-06-11 NZ NZ589839A patent/NZ589839A/en not_active IP Right Cessation
- 2009-06-11 AU AU2009259114A patent/AU2009259114B2/en not_active Ceased
- 2009-06-11 WO PCT/FR2009/051100 patent/WO2009150381A2/fr not_active Ceased
- 2009-06-11 KR KR1020117000721A patent/KR20110016998A/ko not_active Withdrawn
- 2009-06-11 PE PE2010001118A patent/PE20110122A1/es not_active Application Discontinuation
- 2009-06-11 UA UAA201100324A patent/UA101668C2/ru unknown
- 2009-06-11 CN CN2009801313693A patent/CN102124007A/zh active Pending
- 2009-06-12 TW TW098119820A patent/TW201002711A/zh unknown
- 2009-06-12 UY UY0001031895A patent/UY31895A/es not_active Application Discontinuation
2010
- 2010-11-23 ZA ZA2010/08387A patent/ZA201008387B/en unknown
- 2010-11-25 CR CR11814A patent/CR11814A/es not_active Application Discontinuation
- 2010-11-29 DO DO2010000366A patent/DOP2010000366A/es unknown
- 2010-12-03 EC EC2010010670A patent/ECSP10010670A/es unknown
- 2010-12-06 NI NI201000210A patent/NI201000210A/es unknown
- 2010-12-08 IL IL209840A patent/IL209840A0/en unknown
- 2010-12-09 SV SV2010003754A patent/SV2010003754A/es unknown
- 2010-12-09 CO CO10154614A patent/CO6280536A2/es active IP Right Grant
2011
- 2011-01-07 MA MA33499A patent/MA32460B1/fr unknown

Also Published As

Publication number	Publication date
CO6280536A2 (es)	2011-05-20
US20110178053A1 (en)	2011-07-21
UY31895A (es)	2010-01-29
CN102124007A (zh)	2011-07-13
MX2010013699A (es)	2011-02-23
WO2009150381A3 (fr)	2010-02-18
BRPI0915204A2 (pt)	2019-01-15
JP2011522867A (ja)	2011-08-04
TW201002711A (en)	2010-01-16
EP2303882A2 (fr)	2011-04-06
AU2009259114A1 (en)	2009-12-17
KR20110016998A (ko)	2011-02-18
EA018945B1 (ru)	2013-11-29
AR072084A1 (es)	2010-08-04
PE20110122A1 (es)	2011-03-07
SV2010003754A (es)	2011-03-15
CA2725093A1 (fr)	2009-12-17
WO2009150381A2 (fr)	2009-12-17
MA32460B1 (fr)	2011-07-03
ECSP10010670A (es)	2011-01-31
EA201170002A1 (ru)	2011-08-30
IL209840A0 (en)	2011-02-28
ZA201008387B (en)	2012-02-29
DOP2010000366A (es)	2010-12-31
AU2009259114B2 (en)	2013-05-23
NI201000210A (es)	2011-05-09
NZ589839A (en)	2012-07-27
UA101668C2 (ru)	2013-04-25

Legal Events

Date	Code	Title	Description
2015-07-30	FA	Abandonment or withdrawal (granting procedure)

Publication	Publication Date	Title
CR11814A (es)	2011-01-10	Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica
CO6300954A2 (es)	2011-07-21	Derivados de tienopiridinonas como activadores de proteina quinasa activados por ampk
CR20110318A (es)	2011-09-09	Compuestos, composición farmacéutica y métodos para utilizarse en el tratamiento de trastornos metabólicos
CO6311079A2 (es)	2011-08-22	Derivados de aminodihidrotiazina como inhibidores de la enzima bace para el tratamiento de la enfermedad de alzheimer
ECSP109903A (es)	2010-02-26	Derivados de pirazinona y su uso en el tratamiento de enfermedades pulmonares
CR11861A (es)	2011-02-16	Compuestos organicos
UY32543A (es)	2010-11-30	Análogos de isoxazol-3(2h)-ona como agentes terapéuticos
SV2011003855A (es)	2011-05-16	Heteroarilos sustituidos
UY30498A1 (es)	2008-02-29	Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
CR20120264A (es)	2013-01-25	Compuestos
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UY32859A (es)	2011-03-31	Compuestos y composiciones como inhibidores de cinasa de proteina
SV2010003514A (es)	2011-01-31	Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas
UY34314A (es)	2013-04-30	Derivados de anilina, su preparación y su aplicación terapéutica.
CY1114880T1 (el)	2016-12-14	Αγωνιστες mglu2
ECSP109961A (es)	2010-03-31	Derivados de indol-2-ona disustituidos en 3, su preparación y su aplicación en terapéutica
CR20110527A (es)	2014-05-12	Derivados de 1-alquil-cinolin-4(1h)-ona, su preparación y su aplicación en terapéutica
UY30740A1 (es)	2008-07-03	Nuevo procedimiento para la preparacion de 4,4??-( 1-metil-1,2-etandilil)-bis-(2,6-piperazindiona)
ECSP11011053A (es)	2011-06-30	[4-(1-amino-etil)-ciclohexil]-metil-aminas como antibacterianos
UY32448A (es)	2010-09-30	Derivados de 3-benzofuranil-indol-2-ona-3-acetamidopiperazinas sustituidos, su preparacion y su aplicacion en terapeutica
UY32447A (es)	2010-09-30	Derivados de 3-benzofuranilindol-2-ona sustituidos en 3, su preparacion y su aplicacion en terapia
ECSP11011150A (es)	2011-07-29	Derivados de arilciclopropilacetamida útiles como activadores de glucoquinasa
CL2009000317A1 (es)	2010-02-26	Compuestos derivados de 3-alquil-piperazina sustituida; composicion farmaceutica; y su uso en el tratamiento de la depresion y ansiedad.
UA110458C2 (ru)	2016-01-12	Інгібітори ns5a вгс
CL2009000704A1 (es)	2010-02-26	Compuestos derivados de n-benzil-n-(heterociclil-5-il)piperidin-4-amina; composisicon farmaceutica; y su uso para el tratamiento de enfermedades asociadas con inhibidores de monoaminas, tal como ansiedad, depresion o ambas.