CR20110484A - Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen - Google Patents

Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen

Info

Publication number: CR20110484A
Authority: CR; Costa Rica
Prior art keywords: benzotiazepinas; derivatives; new; pharmaceutical compositions; compositions containing
Prior art date: 2009-03-20

Application number

CR20110484A

Other languages

English (en)

Spanish (es)

Inventor

Cordi Alexis

Desos Patrice

Lestage Pierre

Danober Laurence

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-20

Filing date

2011-09-12

Publication date

2011-10-24

2011-09-12 Application filed by Servier Lab filed Critical Servier Lab

2011-10-24 Publication of CR20110484A publication Critical patent/CR20110484A/es

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
-1 carboxy, hydroxy Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CR20110484A 2009-03-20 2011-09-12 Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen CR20110484A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0901300A FR2943342B1 (fr)	2009-03-20	2009-03-20	Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
CR20110484A true CR20110484A (es)	2011-10-24

Family

ID=40863576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CR20110484A CR20110484A (es)	2009-03-20	2011-09-12	Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen

Country Status (44)

Country	Link
US (1)	US8236790B2 (de)
EP (1)	EP2246339B1 (de)
JP (1)	JP5437473B2 (de)
KR (1)	KR101431504B1 (de)
CN (1)	CN102361860B (de)
AP (1)	AP3050A (de)
AR (1)	AR075892A1 (de)
AT (1)	ATE513822T1 (de)
AU (1)	AU2010200815B2 (de)
BR (1)	BRPI1009200A2 (de)
CA (1)	CA2696705C (de)
CL (1)	CL2011002287A1 (de)
CO (1)	CO6361956A2 (de)
CR (1)	CR20110484A (de)
CU (1)	CU24030B1 (de)
CY (1)	CY1111807T1 (de)
DK (1)	DK2246339T3 (de)
EA (1)	EA020259B1 (de)
EC (1)	ECSP11011340A (de)
ES (1)	ES2368691T3 (de)
FR (1)	FR2943342B1 (de)
GE (1)	GEP20135862B (de)
HN (1)	HN2011002458A (de)
HR (1)	HRP20110626T1 (de)
IL (1)	IL215016A (de)
JO (1)	JO2780B1 (de)
MA (1)	MA33131B1 (de)
MX (1)	MX2011009638A (de)
MY (1)	MY154001A (de)
NI (1)	NI201100169A (de)
NZ (1)	NZ595082A (de)
PE (1)	PE20120113A1 (de)
PL (1)	PL2246339T3 (de)
PT (1)	PT2246339E (de)
RS (1)	RS51919B (de)
SA (1)	SA110310217B1 (de)
SG (1)	SG174274A1 (de)
SI (1)	SI2246339T1 (de)
TN (1)	TN2011000469A1 (de)
TW (1)	TWI388326B (de)
UA (1)	UA100477C2 (de)
UY (1)	UY32475A (de)
WO (1)	WO2010106249A1 (de)
ZA (1)	ZA201001905B (de)

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HUE034911T2 (hu)	2009-07-27	2018-03-28	Gilead Sciences Inc	Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok
EP2588197B1 (de)	2010-07-02	2014-11-05	Gilead Sciences, Inc.	Kondensierte heterozyklische verbindungen als ionenkanalmodulatoren
WO2012020848A1 (en)	2010-08-10	2012-02-16	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
MX366925B (es)	2010-11-04	2019-07-31	Albireo Ab	Inhibidores de ibat para el tratamiento de enfermedades hepaticas.
WO2012154760A1 (en)	2011-05-10	2012-11-15	Gilead Sciences, Inc.	Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (de)	2011-07-01	2018-04-28
UY34171A (es) *	2011-07-01	2013-01-31	Gilead Sciences Inc	Compuestos heterocíclicos fusionados como moduladores del canal iónico
AU2015224425B2 (en) *	2011-07-01	2017-02-09	Gilead Sciences, Inc.	Fused benzoxazepinones as ion channel modulators
US9493484B2 (en)	2012-02-08	2016-11-15	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
SG11202108566VA (en)	2019-02-06	2021-09-29	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
TWI873185B (zh)	2019-09-16	2025-02-21	日商武田藥品工業股份有限公司	唑稠合之嗒-3(2h)-酮衍生物
CA3158195A1 (en)	2019-12-04	2021-06-10	Per-Goran Gillberg	Benzothia(di)azepine compounds and their use as bile acid modulators
CN111620838A (zh) *	2020-05-16	2020-09-04	西安都创医药科技有限公司	一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) *	2020-05-16	2020-08-11	西安都创医药科技有限公司	一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) *	2020-05-16	2020-08-18	西安都创医药科技有限公司	一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) *	2020-06-03	2022-09-20	西安都创医药科技有限公司	卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
AU2021379076A1 (en)	2020-11-12	2023-06-08	Albireo Ab	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
BR112023010799A2 (pt)	2020-12-04	2023-10-03	Albireo Ab	Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
CN115368363B (zh) *	2021-05-17	2024-02-20	中山大学	一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用
CN117412955A (zh)	2021-06-03	2024-01-16	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
WO2024240249A1 (zh) *	2023-05-25	2024-11-28	正大天晴药业集团股份有限公司	一种苯并噻二氮卓化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT70955A (en) *	1992-04-15	1995-11-28	Rhone Poulenc Rorer Sa	3,4-dihydro-1,1-dioxo-2h-1,2,4-benzothiadiazine-3-carboxylic acid derivatives, preparation thereof and drugs containing same
AU2594799A (en) *	1998-02-11	1999-08-30	Du Pont Pharmaceuticals Company	Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
RU2214405C2 (ru)	1998-02-18	2003-10-20	НьюроСёрч А/С	Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов
US6156746A (en) *	1998-08-25	2000-12-05	Bristol-Myers Squibb Company	1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) *	2002-04-25	2002-06-05	Astrazeneca Ab	Chemical compounds
DE10300973A1 (de) *	2003-01-14	2004-07-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2877338B1 (fr) *	2004-11-03	2007-01-26	Servier Lab	Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr) *	2004-12-10	2007-02-16	Servier Lab	Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2009
- 2009-03-20 FR FR0901300A patent/FR2943342B1/fr not_active Expired - Fee Related
2010
- 2010-03-02 JO JO201077A patent/JO2780B1/en active
- 2010-03-03 AU AU2010200815A patent/AU2010200815B2/en not_active Ceased
- 2010-03-04 UY UY0001032475A patent/UY32475A/es unknown
- 2010-03-11 TW TW099107121A patent/TWI388326B/zh not_active IP Right Cessation
- 2010-03-17 CA CA2696705A patent/CA2696705C/fr not_active Expired - Fee Related
- 2010-03-17 ZA ZA2010/01905A patent/ZA201001905B/en unknown
- 2010-03-17 SA SA110310217A patent/SA110310217B1/ar unknown
- 2010-03-18 PE PE2011001589A patent/PE20120113A1/es not_active Application Discontinuation
- 2010-03-18 CN CN201080012931.3A patent/CN102361860B/zh not_active Expired - Fee Related
- 2010-03-18 KR KR1020117024772A patent/KR101431504B1/ko not_active Expired - Fee Related
- 2010-03-18 ES ES10290141T patent/ES2368691T3/es active Active
- 2010-03-18 AP AP2011005935A patent/AP3050A/xx active
- 2010-03-18 MA MA34178A patent/MA33131B1/fr unknown
- 2010-03-18 SI SI201030006T patent/SI2246339T1/sl unknown
- 2010-03-18 EA EA201101334A patent/EA020259B1/ru not_active IP Right Cessation
- 2010-03-18 AT AT10290141T patent/ATE513822T1/de active
- 2010-03-18 PL PL10290141T patent/PL2246339T3/pl unknown
- 2010-03-18 UA UAA201112094A patent/UA100477C2/uk unknown
- 2010-03-18 PT PT10290141T patent/PT2246339E/pt unknown
- 2010-03-18 RS RS20110385A patent/RS51919B/sr unknown
- 2010-03-18 JP JP2012500288A patent/JP5437473B2/ja not_active Expired - Fee Related
- 2010-03-18 GE GEAP201012414A patent/GEP20135862B/en unknown
- 2010-03-18 NZ NZ595082A patent/NZ595082A/en not_active IP Right Cessation
- 2010-03-18 BR BRPI1009200A patent/BRPI1009200A2/pt not_active IP Right Cessation
- 2010-03-18 MY MYPI2011004188A patent/MY154001A/en unknown
- 2010-03-18 DK DK10290141.0T patent/DK2246339T3/da active
- 2010-03-18 WO PCT/FR2010/000227 patent/WO2010106249A1/fr not_active Ceased
- 2010-03-18 SG SG2011064367A patent/SG174274A1/en unknown
- 2010-03-18 MX MX2011009638A patent/MX2011009638A/es active IP Right Grant
- 2010-03-18 EP EP10290141A patent/EP2246339B1/de active Active
- 2010-03-19 US US12/661,598 patent/US8236790B2/en not_active Expired - Fee Related
- 2010-03-19 AR ARP100100881A patent/AR075892A1/es unknown
2011
- 2011-08-31 HR HR20110626T patent/HRP20110626T1/hr unknown
- 2011-09-07 IL IL215016A patent/IL215016A/en not_active IP Right Cessation
- 2011-09-07 CU CU2011000169A patent/CU24030B1/es active IP Right Grant
- 2011-09-08 CY CY20111100869T patent/CY1111807T1/el unknown
- 2011-09-12 CR CR20110484A patent/CR20110484A/es unknown
- 2011-09-13 NI NI201100169A patent/NI201100169A/es unknown
- 2011-09-15 CL CL2011002287A patent/CL2011002287A1/es unknown
- 2011-09-19 EC EC2011011340A patent/ECSP11011340A/es unknown
- 2011-09-19 TN TN2011000469A patent/TN2011000469A1/fr unknown
- 2011-09-19 CO CO11121546A patent/CO6361956A2/es active IP Right Grant
- 2011-09-20 HN HN2011002458A patent/HN2011002458A/es unknown

Also Published As

Publication number	Publication date
FR2943342B1 (fr)	2011-03-04
KR101431504B1 (ko)	2014-08-20
UY32475A (es)	2010-09-30
JP5437473B2 (ja)	2014-03-12
UA100477C2 (uk)	2012-12-25
CU24030B1 (es)	2014-10-02
US20100240635A1 (en)	2010-09-23
IL215016A (en)	2013-08-29
CY1111807T1 (el)	2015-10-07
DK2246339T3 (da)	2011-10-10
PL2246339T3 (pl)	2011-11-30
WO2010106249A1 (fr)	2010-09-23
CO6361956A2 (es)	2012-01-20
MY154001A (en)	2015-04-30
AR075892A1 (es)	2011-05-04
AP3050A (en)	2014-11-30
CN102361860B (zh)	2014-09-10
US8236790B2 (en)	2012-08-07
SI2246339T1 (sl)	2011-09-30
CA2696705A1 (fr)	2010-09-20
ES2368691T3 (es)	2011-11-21
AU2010200815B2 (en)	2015-05-07
CL2011002287A1 (es)	2012-02-03
NI201100169A (es)	2012-01-11
TN2011000469A1 (fr)	2013-03-27
SG174274A1 (en)	2011-10-28
AU2010200815A1 (en)	2010-10-07
ATE513822T1 (de)	2011-07-15
EP2246339A1 (de)	2010-11-03
CN102361860A (zh)	2012-02-22
PT2246339E (pt)	2011-08-01
TWI388326B (zh)	2013-03-11
GEP20135862B (en)	2013-06-25
EP2246339B1 (de)	2011-06-22
KR20110128209A (ko)	2011-11-28
EA020259B1 (ru)	2014-09-30
ZA201001905B (en)	2010-11-24
HRP20110626T1 (hr)	2011-10-31
JP2012520858A (ja)	2012-09-10
FR2943342A1 (fr)	2010-09-24
EA201101334A1 (ru)	2012-04-30
ECSP11011340A (es)	2011-10-31
SA110310217B1 (ar)	2013-06-15
IL215016A0 (en)	2011-11-30
CU20110169A7 (es)	2012-02-15
AP2011005935A0 (en)	2011-10-31
RS51919B (sr)	2012-02-29
MX2011009638A (es)	2011-09-28
CA2696705C (fr)	2013-02-12
HN2011002458A (es)	2014-05-19
BRPI1009200A2 (pt)	2017-06-13
PE20120113A1 (es)	2012-02-24
HK1167404A1 (en)	2012-11-30
NZ595082A (en)	2013-12-20
TW201036615A (en)	2010-10-16
MA33131B1 (fr)	2012-03-01
JO2780B1 (en)	2014-03-15

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