CL2011002287A1 - Compuestos derivados de 8-fenoxi-1,1-dioxido-2,3,4,5-tetrahidro-1,2,5-benzotiadiazepina, moduladores de receptores ampa y nmda; composicion farmaceutica; procedimiento de prepapacion; y su uso para tratar enfermedades neurodegenerativas progresivas, alzheimer, parkinson, corea de huntington, entre otras; compuesto intermediario. - Google Patents
Compuestos derivados de 8-fenoxi-1,1-dioxido-2,3,4,5-tetrahidro-1,2,5-benzotiadiazepina, moduladores de receptores ampa y nmda; composicion farmaceutica; procedimiento de prepapacion; y su uso para tratar enfermedades neurodegenerativas progresivas, alzheimer, parkinson, corea de huntington, entre otras; compuesto intermediario.Info
- Publication number
- CL2011002287A1 CL2011002287A1 CL2011002287A CL2011002287A CL2011002287A1 CL 2011002287 A1 CL2011002287 A1 CL 2011002287A1 CL 2011002287 A CL2011002287 A CL 2011002287A CL 2011002287 A CL2011002287 A CL 2011002287A CL 2011002287 A1 CL2011002287 A1 CL 2011002287A1
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- Chile
- Prior art keywords
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- ramified
- linear
- replaced
- rented
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000000750 progressive effect Effects 0.000 title abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 title 1
- 102000003678 AMPA Receptors Human genes 0.000 title 1
- 108090000078 AMPA Receptors Proteins 0.000 title 1
- 208000023105 Huntington disease Diseases 0.000 title 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 title 1
- -1 HYDROXY GROUP Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 3
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UN COMPUESTO DE FORMULA (I): EN LA QUE:<br /> R1 Y R2. IDÉNTICOS O DIFERENTES. REPRESENTAN CADA UNO UN ÁTOMO DE HIDRÓGENO. UN ÁTOMO DE HALÓGENO, O UN GRUPO ALQUILO (C1-C6) LINEAL O RAMIFICADO NO SUSTITUIDO O SUSTITUIDO CON UNO O VARIOS ATAMOS DE HALÓGENO, UN GRUPO ALEOXI (C1- C6) LINEAL O RAMIFICADO, UN GRUPO ALQUILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO ALCOXICARBONILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO CARBOXI, UN GRUPO ACILO (C1-C6) LINEAL O RAMIFICADO. UN GRUPO HIDROXI, UN GRUPO HIDROXIALQUILO (C1-<br /> C6) LINEAL O RAMIFICADO. UN GRUPO CIANO, UN GRUPO NITRO. UN GRUPO AMINO NO SUSTITUIDO O SUSTITUIDO CON UNO O VARIOS GRUPOS ALQUILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO AMINO SUSTITUIDO CON UN GRUPO ACILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO AMINOCARBONILO NO SUSTITUIDO O SUSTITUIDO CON UNO O VARIOS GRUPOS ALQUILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO AMINOSULFONILO NO SUSTITUIDO O SUSTITUIDO CON UNO O VARIOS GRUPOS ALQUILO (C1-C6) LINEAL O RAMIFICADO, UN GRUPO ALQUIL(C1-C6) SULFONILAMINOALQUILO (C1-C6) LINEAL O RAMIFICADO. UN GRUPO N-HIDROXICARBOXIMIDAMIDA O UN GRUPO BENCILOXI, R3, REPRESENTA UN ÁTOMO DE HIDRÓGENO O UN GRUPO ALQUILO (C1-C6) LINEAL O RAMIFICADO, CICLOALQUILO (C3-C6) O<br /> CICLOALQUIL(C3-C6)ALQUILO (C1-C6) LINEAL O RAMIFICADO, R4, REPRESENTA UN ÁTOMO DE HIDRÓGENO O UN GRUPO ALQUILO (C1-C6) LINEAL O RAMIFICADO NO SUSTITUIDO O SUSTITUIDO CON UNO O VARIOS ÁTOMOS DE HALÓGENO. SUS ISÓMEROS ÓPTICOS Y DE POSICIÓN ASI COMO SUS SALES DE ADICIÓN A UN ÁCIDO O A UNA BASE FARMACÉUTICAMENTE ACEPTABLE.<br /> COMPOSICIÓN FARMACÉUTICA; PROCEDIMIENTO DE PREPARACIÓN; Y USO EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS PROGRESIVAS, ALZHEIMER, PARKINSON, COREA DE HUNTINGTON, ENTRE OTRAS; COMPUESTO INTERMEDIARIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901300A FR2943342B1 (fr) | 2009-03-20 | 2009-03-20 | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011002287A1 true CL2011002287A1 (es) | 2012-02-03 |
Family
ID=40863576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011002287A CL2011002287A1 (es) | 2009-03-20 | 2011-09-15 | Compuestos derivados de 8-fenoxi-1,1-dioxido-2,3,4,5-tetrahidro-1,2,5-benzotiadiazepina, moduladores de receptores ampa y nmda; composicion farmaceutica; procedimiento de prepapacion; y su uso para tratar enfermedades neurodegenerativas progresivas, alzheimer, parkinson, corea de huntington, entre otras; compuesto intermediario. |
Country Status (44)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2464645T (pt) * | 2009-07-27 | 2017-10-11 | Gilead Sciences Inc | Compostos heterocíclicos fusionados como moduladores do canal de iões |
| WO2012003392A1 (en) | 2010-07-02 | 2012-01-05 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| SI2603513T1 (sl) | 2010-08-10 | 2020-07-31 | Takeda Pharmaceutical Company Limited | Heterociklična spojina in njena uporaba kot pozitivni alosterični modulator receptorja AMPA |
| ES2586931T3 (es) | 2010-11-04 | 2016-10-19 | Albireo Ab | Inhibidores de IBAT para el tratamiento de enfermedades hepáticas |
| AU2012253653A1 (en) | 2011-05-10 | 2013-05-02 | Gilead Sciences, Inc. | Fused heterocyclic compounds as sodium channel modulators |
| NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
| TWI622583B (zh) * | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| AU2015224425B2 (en) * | 2011-07-01 | 2017-02-09 | Gilead Sciences, Inc. | Fused benzoxazepinones as ion channel modulators |
| US9493484B2 (en) | 2012-02-08 | 2016-11-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| RS63899B1 (sr) | 2019-02-06 | 2023-02-28 | Albireo Ab | Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina |
| PL4031552T3 (pl) | 2019-09-16 | 2025-03-17 | Takeda Pharmaceutical Company Limited | Pochodne azolowo-skondensowanych pirydazyn-3(2h)-onów |
| BR112022010505A2 (pt) | 2019-12-04 | 2022-09-06 | Albireo Ab | Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar |
| CN111548325A (zh) * | 2020-05-16 | 2020-08-18 | 西安都创医药科技有限公司 | 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111518055A (zh) * | 2020-05-16 | 2020-08-11 | 西安都创医药科技有限公司 | 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用 |
| CN111620838A (zh) * | 2020-05-16 | 2020-09-04 | 西安都创医药科技有限公司 | 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用 |
| CN111574475B (zh) * | 2020-06-03 | 2022-09-20 | 西安都创医药科技有限公司 | 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用 |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CN115368363B (zh) * | 2021-05-17 | 2024-02-20 | 中山大学 | 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| CN121175293A (zh) * | 2023-05-25 | 2025-12-19 | 正大天晴药业集团股份有限公司 | 一种苯并噻二氮卓化合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0636124A1 (fr) * | 1992-04-15 | 1995-02-01 | Aventis Pharma S.A. | Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant |
| EP1054877A1 (en) * | 1998-02-11 | 2000-11-29 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| CA2320354A1 (en) | 1998-02-18 | 1999-08-26 | Neurosearch A/S | Novel compounds and their use as positive ampa receptor modulators |
| US6156746A (en) * | 1998-08-25 | 2000-12-05 | Bristol-Myers Squibb Company | 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents |
| GB0209467D0 (en) * | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10300973A1 (de) * | 2003-01-14 | 2004-07-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| FR2877338B1 (fr) * | 2004-11-03 | 2007-01-26 | Servier Lab | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2009
- 2009-03-20 FR FR0901300A patent/FR2943342B1/fr not_active Expired - Fee Related
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2010
- 2010-03-02 JO JO201077A patent/JO2780B1/en active
- 2010-03-03 AU AU2010200815A patent/AU2010200815B2/en not_active Ceased
- 2010-03-04 UY UY0001032475A patent/UY32475A/es unknown
- 2010-03-11 TW TW099107121A patent/TWI388326B/zh not_active IP Right Cessation
- 2010-03-17 SA SA110310217A patent/SA110310217B1/ar unknown
- 2010-03-17 CA CA2696705A patent/CA2696705C/fr not_active Expired - Fee Related
- 2010-03-17 ZA ZA2010/01905A patent/ZA201001905B/en unknown
- 2010-03-18 ES ES10290141T patent/ES2368691T3/es active Active
- 2010-03-18 MA MA34178A patent/MA33131B1/fr unknown
- 2010-03-18 BR BRPI1009200A patent/BRPI1009200A2/pt not_active IP Right Cessation
- 2010-03-18 WO PCT/FR2010/000227 patent/WO2010106249A1/fr not_active Ceased
- 2010-03-18 SI SI201030006T patent/SI2246339T1/sl unknown
- 2010-03-18 NZ NZ595082A patent/NZ595082A/en not_active IP Right Cessation
- 2010-03-18 KR KR1020117024772A patent/KR101431504B1/ko not_active Expired - Fee Related
- 2010-03-18 SG SG2011064367A patent/SG174274A1/en unknown
- 2010-03-18 PE PE2011001589A patent/PE20120113A1/es not_active Application Discontinuation
- 2010-03-18 JP JP2012500288A patent/JP5437473B2/ja not_active Expired - Fee Related
- 2010-03-18 CN CN201080012931.3A patent/CN102361860B/zh not_active Expired - Fee Related
- 2010-03-18 DK DK10290141.0T patent/DK2246339T3/da active
- 2010-03-18 GE GEAP201012414A patent/GEP20135862B/en unknown
- 2010-03-18 MY MYPI2011004188A patent/MY154001A/en unknown
- 2010-03-18 AT AT10290141T patent/ATE513822T1/de active
- 2010-03-18 PL PL10290141T patent/PL2246339T3/pl unknown
- 2010-03-18 UA UAA201112094A patent/UA100477C2/uk unknown
- 2010-03-18 AP AP2011005935A patent/AP3050A/xx active
- 2010-03-18 EA EA201101334A patent/EA020259B1/ru not_active IP Right Cessation
- 2010-03-18 MX MX2011009638A patent/MX2011009638A/es active IP Right Grant
- 2010-03-18 PT PT10290141T patent/PT2246339E/pt unknown
- 2010-03-18 EP EP10290141A patent/EP2246339B1/fr active Active
- 2010-03-18 RS RS20110385A patent/RS51919B/sr unknown
- 2010-03-19 US US12/661,598 patent/US8236790B2/en not_active Expired - Fee Related
- 2010-03-19 AR ARP100100881A patent/AR075892A1/es unknown
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2011
- 2011-08-31 HR HR20110626T patent/HRP20110626T1/hr unknown
- 2011-09-07 IL IL215016A patent/IL215016A/en not_active IP Right Cessation
- 2011-09-07 CU CU2011000169A patent/CU24030B1/es active IP Right Grant
- 2011-09-08 CY CY20111100869T patent/CY1111807T1/el unknown
- 2011-09-12 CR CR20110484A patent/CR20110484A/es unknown
- 2011-09-13 NI NI201100169A patent/NI201100169A/es unknown
- 2011-09-15 CL CL2011002287A patent/CL2011002287A1/es unknown
- 2011-09-19 TN TN2011000469A patent/TN2011000469A1/fr unknown
- 2011-09-19 CO CO11121546A patent/CO6361956A2/es active IP Right Grant
- 2011-09-19 EC EC2011011340A patent/ECSP11011340A/es unknown
- 2011-09-20 HN HN2011002458A patent/HN2011002458A/es unknown
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