CR20110603A - Indazoles de oxasol sustituidos como inhibidores de p13-kinasa - Google Patents

Indazoles de oxasol sustituidos como inhibidores de p13-kinasa

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Publication number
CR20110603A
CR20110603A CR20110603A CR20110603A CR20110603A CR 20110603 A CR20110603 A CR 20110603A CR 20110603 A CR20110603 A CR 20110603A CR 20110603 A CR20110603 A CR 20110603A CR 20110603 A CR20110603 A CR 20110603A
Authority
CR
Costa Rica
Prior art keywords
indazols
oxasol
kinasa
inhibitors
replaced
Prior art date
Application number
CR20110603A
Other languages
English (en)
Inventor
Julie Nicole Hamblin
Paul Spencer Jones
Suzanne Elaine Keeling
Joelle Le
Charlotte Jane Mitchell
Nigel James Parr
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CR20110603A publication Critical patent/CR20110603A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
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Abstract

Un aparato pra tratamiento físico y biológico para tratar las aguas residuales domésticas y que se utiliza para darle una mejor calidad de agua de salida de ésta antes de su descarga, disposición o reutilización.
CR20110603A 2009-04-30 2011-11-15 Indazoles de oxasol sustituidos como inhibidores de p13-kinasa CR20110603A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30

Publications (1)

Publication Number Publication Date
CR20110603A true CR20110603A (es) 2012-02-28

Family

ID=42225106

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110603A CR20110603A (es) 2009-04-30 2011-11-15 Indazoles de oxasol sustituidos como inhibidores de p13-kinasa

Country Status (39)

Country Link
US (14) US8580797B2 (es)
EP (3) EP3260453B1 (es)
JP (1) JP5570589B2 (es)
KR (2) KR101771193B1 (es)
CN (1) CN102459253B (es)
AR (2) AR076435A1 (es)
AU (1) AU2010243613B2 (es)
BR (1) BRPI1016219B8 (es)
CA (1) CA2759476C (es)
CL (1) CL2011002706A1 (es)
CO (1) CO6390057A2 (es)
CR (1) CR20110603A (es)
CY (1) CY1119515T1 (es)
DK (2) DK2424864T3 (es)
DO (1) DOP2011000328A (es)
EA (1) EA021056B1 (es)
ES (3) ES2876933T3 (es)
HR (2) HRP20150173T1 (es)
HU (1) HUE034724T2 (es)
IL (1) IL215803A (es)
JO (1) JO3025B1 (es)
LT (1) LT2899191T (es)
MA (1) MA33304B1 (es)
ME (2) ME02053B (es)
MX (1) MX2011011534A (es)
MY (1) MY160454A (es)
NZ (1) NZ596071A (es)
PE (1) PE20120321A1 (es)
PL (2) PL2899191T3 (es)
PT (2) PT2899191T (es)
RS (2) RS53830B1 (es)
SG (2) SG175782A1 (es)
SI (2) SI2424864T1 (es)
SM (2) SMT201700481T1 (es)
TW (3) TWI466884B (es)
UA (1) UA101098C2 (es)
UY (1) UY32585A (es)
WO (1) WO2010125082A1 (es)
ZA (1) ZA201107878B (es)

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WO2009147188A1 (en) * 2008-06-05 2009-12-10 Glaxo Group Limited Benzpyrazol derivatives as inhibitors of pi3 kinases
JP5502076B2 (ja) 2008-06-05 2014-05-28 グラクソ グループ リミテッド 新規化合物
US8524751B2 (en) 2009-03-09 2013-09-03 GlaxoSmithKline Intellecutual Property Development 4-oxadiazol-2-YL-indazoles as inhibitors of P13 kinases
RS53830B1 (sr) 2009-04-30 2015-06-30 Glaxo Group Limited Indazoli supstituisani oksazolom kao inhibitori pi3-kinaze
CN102372675B (zh) * 2010-08-14 2013-12-18 王娜 6-氯-4-碘吲唑及其制备方法与应用
EP2613781B1 (en) 2010-09-08 2016-08-24 GlaxoSmithKline Intellectual Property Development Limited Indazole derivatives for use in the treatment of influenza virus infection
US9102668B2 (en) * 2010-09-08 2015-08-11 Glaxo Group Limited Polymorphs and salts
HRP20151017T1 (hr) 2010-09-08 2015-10-23 Glaxosmithkline Intellectual Property Development Limited Polimorfi i soli n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4-morfolinil]metil}-1,3-oksazol-2-il)-1h-indazol-6-il]-2-(metiloksi)-3-piridinil]metansulfonamida
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
JP6063870B2 (ja) * 2010-11-08 2017-01-18 ライセラ・コーポレイション ＲＯＲγ活性の阻害用のＮ−スルホニル化テトラヒドロキノリンおよび関連二環化合物および病気の治療
ES2661510T3 (es) 2011-12-15 2018-04-02 Novartis Ag Uso de inhibidores de la actividad o función de PI3K
EP2847198B1 (en) 2012-05-08 2016-12-14 Lycera Corporation Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of ror-gamma and the treatment of disease
RU2014149136A (ru) 2012-05-08 2016-07-10 Мерк Шарп И Доум Корп. ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ
EP2872143B1 (en) * 2012-07-16 2017-12-13 Neuropore Therapies, Inc. Di-and tri-heteroaryl derivatives as inhibitors of protein aggregation
WO2014068070A1 (en) 2012-10-31 2014-05-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
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