CR20120506A - PROTEÍNAS QUE SE UNEN AL TNF-a - Google Patents

PROTEÍNAS QUE SE UNEN AL TNF-a

Info

Publication number
CR20120506A
CR20120506A CR20120506A CR20120506A CR20120506A CR 20120506 A CR20120506 A CR 20120506A CR 20120506 A CR20120506 A CR 20120506A CR 20120506 A CR20120506 A CR 20120506A CR 20120506 A CR20120506 A CR 20120506A
Authority
CR
Costa Rica
Prior art keywords
antibodies
tnf
proteins
join
bind
Prior art date
Application number
CR20120506A
Other languages
English (en)
Inventor
Lorenzo Benatuil
Tariq Ghayur
Carrie L Goodreau
Peter C Isakson
Jochen Salfeld
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44761064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120506(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CR20120506A publication Critical patent/CR20120506A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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Abstract

Proteínas de unión aisladas, por ejemplo, anticuerpos o porciones de unión al antígeno de éstos, que se unen al factor de necrosis tumoral-alfa (TNF-a), por ejemplo, al TNF-a humano. Composiciones basadas en anticuerpos. Moléculas relacionadas. Composiciones farmacéuticas que comprenden dichos anticuerpos. Métodos terapéuticos y de diagnóstico donde se emplean dichos anticuerpos.
CR20120506A 2010-04-07 2012-10-05 PROTEÍNAS QUE SE UNEN AL TNF-a CR20120506A (es)

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US20160176958A1 (en) 2016-06-23
AU2011237679A1 (en) 2012-11-01
KR20130010123A (ko) 2013-01-25
TW201138825A (en) 2011-11-16
CL2012002783A1 (es) 2013-07-12
CO6630164A2 (es) 2013-03-01
US20110250130A1 (en) 2011-10-13
JP2013523153A (ja) 2013-06-17
AU2011237679B2 (en) 2014-11-06
CA2795734A1 (en) 2011-10-13
WO2011127141A1 (en) 2011-10-13
BR112012025568A2 (pt) 2017-03-28
AR080840A1 (es) 2012-05-09
UY33319A (es) 2011-12-01
CN102958537A (zh) 2013-03-06
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ECSP12012272A (es) 2012-11-30
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PH12012501991A1 (en) 2017-07-26
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EP2555797A4 (en) 2014-02-12

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