CR20130371A - IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS - Google Patents

IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS

Info

Publication number
CR20130371A
CR20130371A CR20130371A CR20130371A CR20130371A CR 20130371 A CR20130371 A CR 20130371A CR 20130371 A CR20130371 A CR 20130371A CR 20130371 A CR20130371 A CR 20130371A CR 20130371 A CR20130371 A CR 20130371A
Authority
CR
Costa Rica
Prior art keywords
treatment
triazins
imidazo
neurological disorders
preparation
Prior art date
Application number
CR20130371A
Other languages
English (en)
Inventor
Thomas Allen Chappie
John Michael Humphrey
Patrick Robert Verhoest
Eddie Yang
Christopher John Helal
Original Assignee
Kimberly Clark Co
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45755439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20130371(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kimberly Clark Co, Pfizer filed Critical Kimberly Clark Co
Publication of CR20130371A publication Critical patent/CR20130371A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA (I) Y A SALES DE LOS MISMOS FARMACÉUTICAMENTE ACEPTABLES, A PROCEDIMIENTOS PARA LA PREPARACIÓN DE, A INTERMEDIOS USADOS EN LA PREPARACIÓN DE, Y COMPOSICIONES QUE CONTIENEN DICHOS COMPUSTOS Y A LOS USOS DE DICHOS COMPUESTOS COMO UN PROCEDIMIENTO PARA EL TRATAMIENTO.-
CR20130371A 2011-02-23 2013-07-31 IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS CR20130371A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161445617P 2011-02-23 2011-02-23

Publications (1)

Publication Number Publication Date
CR20130371A true CR20130371A (es) 2013-09-18

Family

ID=45755439

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130371A CR20130371A (es) 2011-02-23 2013-07-31 IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLÓGICOS

Country Status (31)

Country Link
US (2) US8598155B2 (es)
EP (1) EP2681218A1 (es)
JP (1) JP5543039B2 (es)
KR (1) KR101548443B1 (es)
CN (1) CN103391941A (es)
AP (1) AP2013007070A0 (es)
AR (1) AR085304A1 (es)
AU (1) AU2012221828C1 (es)
BR (1) BR112013021366A2 (es)
CA (1) CA2825699A1 (es)
CL (1) CL2013002125A1 (es)
CO (1) CO6751271A2 (es)
CR (1) CR20130371A (es)
CU (1) CU20130107A7 (es)
DO (1) DOP2013000194A (es)
EA (1) EA022586B1 (es)
EC (1) ECSP13012892A (es)
GT (1) GT201300206A (es)
IL (1) IL227716A0 (es)
MA (1) MA34922B1 (es)
MX (1) MX2013009684A (es)
NI (1) NI201300071A (es)
PE (1) PE20140236A1 (es)
PH (1) PH12013501556A1 (es)
SG (1) SG192576A1 (es)
TN (1) TN2013000349A1 (es)
TW (1) TWI469983B (es)
UA (1) UA106692C2 (es)
UY (1) UY33916A (es)
WO (1) WO2012114222A1 (es)
ZA (1) ZA201306348B (es)

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US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
AU2014261070A1 (en) 2013-05-02 2015-10-29 Pfizer Inc. Imidazo-triazine derivatives as PDE10 inhibitors
WO2015096651A1 (en) 2013-12-23 2015-07-02 Merck Sharp & Dohme Corp. Pyrimidone carboxamide compounds as pde2 inhibitors
EP3091983B1 (en) 2014-01-08 2019-10-02 Intra-Cellular Therapies, Inc. Pharmaceutical compositions comprising a pde-1 inhibitor and a pde-2 inhibitor
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US10239882B2 (en) 2014-11-05 2019-03-26 Dart Neuroscience (Cayman) Ltd. Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
CN107205993B (zh) 2014-12-06 2021-03-09 细胞内治疗公司 有机化合物
US10300064B2 (en) * 2014-12-06 2019-05-28 Intra-Cellular Therapies, Inc. Organic compounds
CN104525240A (zh) * 2014-12-10 2015-04-22 河北工业大学 硝酸铁作为催化剂在苯与羟胺盐反应一步法制苯胺反应中的应用方法
WO2016103097A1 (en) 2014-12-22 2016-06-30 Pfizer Inc. Antagonists of prostaglandin ep3 receptor
TWI713497B (zh) * 2015-02-26 2020-12-21 南韓商愛思開生物製藥股份有限公司 咪唑并嘧啶及咪唑并三衍生物及包含該衍生物之醫藥組成物
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
WO2016179059A1 (en) 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2016191935A1 (en) 2015-05-29 2016-12-08 Merck Sharp & Dohme Corp. 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors
WO2016192083A1 (en) 2015-06-04 2016-12-08 Merck Sharp & Dohme Corp. Dihydropyrazolopyrimidinone compounds as pde2 inhibitors
US10647727B2 (en) 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017000277A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Substituted triazolo bicycliccompounds as pde2 inhibitors
WO2017000276A1 (en) 2015-07-01 2017-01-05 Merck Sharp & Dohme Corp. Bicyclic heterocyclic compounds as pde2 inhibitors
CN108349979B (zh) 2015-11-02 2021-04-09 詹森药业有限公司 [1,2,4]三唑并[1,5-a]嘧啶-7-基化合物
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
WO2018065288A1 (de) 2016-10-07 2018-04-12 Bayer Cropscience Aktiengesellschaft 2-[2-phenyl-1-(sulfonylmethyl)vinyl]-imidazo[4,5-b]pyridin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel im pflanzenschutz
EA039102B1 (ru) 2016-11-02 2021-12-03 Янссен Фармацевтика Нв Соединения [1,2,4]триазоло[1,5-a]пиримидина в качестве ингибиторов pde2
CN109890824B (zh) 2016-11-02 2022-05-24 詹森药业有限公司 作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
MY193511A (en) 2016-11-02 2022-10-17 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
AU2018208422B2 (en) 2017-01-10 2021-11-11 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
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EP3870300B1 (en) * 2018-10-23 2024-07-10 Intra-Cellular Therapies, Inc. Imidazo[1,5-a]pyrazine compounds as pde2 inhibitors
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Also Published As

Publication number Publication date
AR085304A1 (es) 2013-09-18
JP5543039B2 (ja) 2014-07-09
US20120214791A1 (en) 2012-08-23
CN103391941A (zh) 2013-11-13
IL227716A0 (en) 2013-09-30
AU2012221828C1 (en) 2015-10-01
MA34922B1 (fr) 2014-02-01
KR101548443B1 (ko) 2015-08-28
NI201300071A (es) 2014-02-12
PE20140236A1 (es) 2014-03-14
CA2825699A1 (en) 2012-08-30
NZ613373A (en) 2015-04-24
EP2681218A1 (en) 2014-01-08
CL2013002125A1 (es) 2013-12-20
AU2012221828B2 (en) 2015-05-28
SG192576A1 (en) 2013-09-30
BR112013021366A2 (pt) 2016-09-13
TWI469983B (zh) 2015-01-21
MX2013009684A (es) 2013-10-28
UY33916A (es) 2012-09-28
TW201247673A (en) 2012-12-01
JP2014506589A (ja) 2014-03-17
ZA201306348B (en) 2014-04-30
KR20130132612A (ko) 2013-12-04
DOP2013000194A (es) 2014-01-31
TN2013000349A1 (fr) 2015-01-20
CU20130107A7 (es) 2013-09-27
WO2012114222A1 (en) 2012-08-30
GT201300206A (es) 2015-02-19
UA106692C2 (uk) 2014-09-25
AP2013007070A0 (en) 2013-08-31
US20140066622A1 (en) 2014-03-06
US8598155B2 (en) 2013-12-03
PH12013501556A1 (en) 2017-10-25
US9200000B2 (en) 2015-12-01
EA201390971A1 (ru) 2014-02-28
CO6751271A2 (es) 2013-09-16
EA022586B1 (ru) 2016-01-29
ECSP13012892A (es) 2013-10-31

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