CR20130476A - Derivados de pirazolidin-3-ona - Google Patents
Derivados de pirazolidin-3-onaInfo
- Publication number
- CR20130476A CR20130476A CR20130476A CR20130476A CR20130476A CR 20130476 A CR20130476 A CR 20130476A CR 20130476 A CR20130476 A CR 20130476A CR 20130476 A CR20130476 A CR 20130476A CR 20130476 A CR20130476 A CR 20130476A
- Authority
- CR
- Costa Rica
- Prior art keywords
- lower alkyl
- derivatives
- hydrogen
- pirazolidin
- ona
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A DERIVADOS DE ETINILO DE LA FÓRMULA I EN LA QUE: X es N o CH; G es N o CH; CON LA CONDICIÓN DE QUE COMO MÁXIMO UNO X Y G PUEDA SER NITRÓGENO; R1 ES FENILO O PIRIDILO, QUE ESTÁN OPCIONALMENTE SUSTITUIDOS POR HALÓGENOS, ALQUILO INFERIOR O ALCOXI INFERIOR; R2 ES HIDRÓGENO, ALQUILO INFERIOR O JUNTO CON R4 PUEDE FORMAR UN CICLOALQUILO C3-C6; R3/R3´/R4/R4´ CON INDEPENDIENTE ENTRE SÍ SON HIDRÓGENO, ALQUILO INFERIOR O CF3; O A UNA SAL DE ADICIÓN DE ÁCIDO FARMACÉUTICAMENTE ACEPTABLE, A UNA MEZCLA RACÉMICA, O A SUS ENANTIÓMEROS Y/O ISÓMEROS ÓPTICOS Y/O ESTEREOISÓMEROS CORRESPONDIENTES.-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11163708 | 2011-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20130476A true CR20130476A (es) | 2013-11-11 |
Family
ID=45998366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20130476A CR20130476A (es) | 2011-04-26 | 2013-09-23 | Derivados de pirazolidin-3-ona |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8648088B2 (es) |
| EP (1) | EP2702050B1 (es) |
| JP (1) | JP5753626B2 (es) |
| KR (1) | KR101576343B1 (es) |
| CN (1) | CN103492374B (es) |
| AR (1) | AR086037A1 (es) |
| CA (1) | CA2829171C (es) |
| CL (1) | CL2013003068A1 (es) |
| CO (1) | CO6801735A2 (es) |
| CR (1) | CR20130476A (es) |
| EA (1) | EA023146B1 (es) |
| EC (1) | ECSP13012990A (es) |
| ES (1) | ES2580333T3 (es) |
| IL (1) | IL229005A (es) |
| MA (1) | MA35134B1 (es) |
| MX (1) | MX2013011107A (es) |
| MY (1) | MY165141A (es) |
| PE (1) | PE20141168A1 (es) |
| PH (1) | PH12013501928A1 (es) |
| SG (1) | SG194095A1 (es) |
| TW (1) | TWI434840B (es) |
| UA (1) | UA113625C2 (es) |
| WO (1) | WO2012146552A1 (es) |
| ZA (1) | ZA201307404B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA110862C2 (uk) * | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| UA116023C2 (uk) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
| AU2016273751B2 (en) * | 2015-06-03 | 2020-04-02 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| TR201909160T4 (tr) | 2015-07-15 | 2019-07-22 | Hoffmann La Roche | Metabotropik glutamat reseptörü modülatörleri olarak etinil türevleri. |
| AR105556A1 (es) * | 2015-08-03 | 2017-10-18 | Hoffmann La Roche | Derivados de etinilo |
| WO2018015235A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| WO2026072192A1 (en) | 2024-09-27 | 2026-04-02 | Alto Neuroscience, Inc. | Effective treatment of depression in patients having poor cognition or impaired learning and/or memory with a mglur5 positive allosteric modulator |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| AU2005336513B2 (en) * | 2004-10-07 | 2012-08-09 | Merck Sharp & Dohme Llc | Thiazolyl mGluR5 antagonists and methods for their use |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| KR20080034944A (ko) * | 2005-08-19 | 2008-04-22 | 아스트라제네카 아베 | 결핵 치료용 피라졸론 유도체 |
| KR20100033981A (ko) | 2007-06-03 | 2010-03-31 | 벤더르빌트 유니버시티 | 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법 |
| US8853392B2 (en) * | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
-
2012
- 2012-04-23 MY MYPI2013003847A patent/MY165141A/en unknown
- 2012-04-23 EP EP12716007.5A patent/EP2702050B1/en active Active
- 2012-04-23 EA EA201391538A patent/EA023146B1/ru not_active IP Right Cessation
- 2012-04-23 JP JP2014505663A patent/JP5753626B2/ja not_active Expired - Fee Related
- 2012-04-23 PH PH1/2013/501928A patent/PH12013501928A1/en unknown
- 2012-04-23 MX MX2013011107A patent/MX2013011107A/es active IP Right Grant
- 2012-04-23 ES ES12716007.5T patent/ES2580333T3/es active Active
- 2012-04-23 PE PE2013002402A patent/PE20141168A1/es active IP Right Grant
- 2012-04-23 CA CA2829171A patent/CA2829171C/en not_active Expired - Fee Related
- 2012-04-23 SG SG2013074414A patent/SG194095A1/en unknown
- 2012-04-23 KR KR1020137031117A patent/KR101576343B1/ko not_active Expired - Fee Related
- 2012-04-23 WO PCT/EP2012/057336 patent/WO2012146552A1/en not_active Ceased
- 2012-04-23 UA UAA201313476A patent/UA113625C2/uk unknown
- 2012-04-23 CN CN201280019941.9A patent/CN103492374B/zh not_active Expired - Fee Related
- 2012-04-24 US US13/454,167 patent/US8648088B2/en not_active Expired - Fee Related
- 2012-04-24 AR ARP120101406A patent/AR086037A1/es unknown
- 2012-04-25 TW TW101114780A patent/TWI434840B/zh not_active IP Right Cessation
-
2013
- 2013-08-29 CO CO13205224A patent/CO6801735A2/es active IP Right Grant
- 2013-09-23 CR CR20130476A patent/CR20130476A/es unknown
- 2013-10-03 ZA ZA2013/07404A patent/ZA201307404B/en unknown
- 2013-10-21 IL IL229005A patent/IL229005A/en active IP Right Grant
- 2013-10-23 CL CL2013003068A patent/CL2013003068A1/es unknown
- 2013-10-24 EC ECSP13012990 patent/ECSP13012990A/es unknown
- 2013-11-22 MA MA36463A patent/MA35134B1/fr unknown
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