CR20140238A - Derivados nucleósidos con sustitución 2´, 4´- difluoro-2´-metilo como inhibidores de la replicación del arn del vhc - Google Patents

Derivados nucleósidos con sustitución 2´, 4´- difluoro-2´-metilo como inhibidores de la replicación del arn del vhc

Info

Publication number
CR20140238A
CR20140238A CR20140238A CR20140238A CR20140238A CR 20140238 A CR20140238 A CR 20140238A CR 20140238 A CR20140238 A CR 20140238A CR 20140238 A CR20140238 A CR 20140238A CR 20140238 A CR20140238 A CR 20140238A
Authority
CR
Costa Rica
Prior art keywords
nucleosid
difluoro
inhibitors
derivatives
replacement
Prior art date
Application number
CR20140238A
Other languages
English (en)
Inventor
Jing Zhang
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20140238A publication Critical patent/CR20140238A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente exposición se refiere a compuestos de Fórmula I
CR20140238A 2011-12-20 2014-05-21 Derivados nucleósidos con sustitución 2´, 4´- difluoro-2´-metilo como inhibidores de la replicación del arn del vhc CR20140238A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161577707P 2011-12-20 2011-12-20

Publications (1)

Publication Number Publication Date
CR20140238A true CR20140238A (es) 2014-06-20

Family

ID=47504913

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140238A CR20140238A (es) 2011-12-20 2014-05-21 Derivados nucleósidos con sustitución 2´, 4´- difluoro-2´-metilo como inhibidores de la replicación del arn del vhc

Country Status (31)

Country Link
US (1) US9108999B2 (es)
EP (1) EP2794629B1 (es)
JP (1) JP5982007B2 (es)
KR (1) KR101765997B1 (es)
CN (1) CN104011061B (es)
AU (1) AU2012357940B2 (es)
BR (1) BR112014013661B1 (es)
CA (1) CA2856179C (es)
CL (1) CL2014001562A1 (es)
CO (1) CO6960551A2 (es)
CR (1) CR20140238A (es)
CY (1) CY1119056T1 (es)
DK (1) DK2794629T3 (es)
EA (1) EA024297B1 (es)
ES (1) ES2636448T3 (es)
HU (1) HUE033727T2 (es)
IL (1) IL232505B (es)
LT (1) LT2794629T (es)
MA (1) MA35750B1 (es)
MX (1) MX350809B (es)
MY (1) MY171577A (es)
PE (1) PE20141423A1 (es)
PH (1) PH12014501134B1 (es)
PL (1) PL2794629T3 (es)
PT (1) PT2794629T (es)
RS (1) RS56212B1 (es)
SG (1) SG11201403364PA (es)
SI (1) SI2794629T1 (es)
UA (1) UA111761C2 (es)
WO (1) WO2013092481A1 (es)
ZA (1) ZA201404273B (es)

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Publication number Publication date
SG11201403364PA (en) 2014-07-30
BR112014013661B1 (pt) 2020-10-27
PH12014501134A1 (en) 2014-07-28
KR20140108290A (ko) 2014-09-05
BR112014013661A8 (pt) 2017-12-19
PT2794629T (pt) 2017-07-20
CA2856179C (en) 2017-02-28
LT2794629T (lt) 2017-07-25
BR112014013661A2 (pt) 2017-06-13
ES2636448T3 (es) 2017-10-05
CO6960551A2 (es) 2014-05-30
MX350809B (es) 2017-09-20
CN104011061B (zh) 2017-06-13
UA111761C2 (uk) 2016-06-10
SI2794629T1 (sl) 2017-10-30
US9108999B2 (en) 2015-08-18
HK1200836A1 (en) 2015-08-14
HUE033727T2 (en) 2018-01-29
CA2856179A1 (en) 2013-06-27
WO2013092481A1 (en) 2013-06-27
EA201491179A1 (ru) 2014-11-28
AU2012357940A1 (en) 2014-05-29
RS56212B1 (sr) 2017-11-30
NZ625342A (en) 2016-07-29
CN104011061A (zh) 2014-08-27
PL2794629T3 (pl) 2018-02-28
AU2012357940B2 (en) 2017-02-16
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DK2794629T3 (en) 2017-07-24
PE20141423A1 (es) 2014-10-16
EA024297B1 (ru) 2016-09-30
MA35750B1 (fr) 2014-12-01
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CL2014001562A1 (es) 2014-11-14
KR101765997B1 (ko) 2017-08-07
JP2015500852A (ja) 2015-01-08
ZA201404273B (en) 2015-09-30
JP5982007B2 (ja) 2016-08-31
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US20150004135A1 (en) 2015-01-01
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IL232505B (en) 2019-02-28
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