MA35660B1 - Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile - Google Patents

Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile

Info

Publication number
MA35660B1
MA35660B1 MA37064A MA37064A MA35660B1 MA 35660 B1 MA35660 B1 MA 35660B1 MA 37064 A MA37064 A MA 37064A MA 37064 A MA37064 A MA 37064A MA 35660 B1 MA35660 B1 MA 35660B1
Authority
MA
Morocco
Prior art keywords
fragile
syndrome
treatment
inhibitors
pak protein
Prior art date
Application number
MA37064A
Other languages
English (en)
Inventor
John C Mckew
Wenwei Huang
David Campbell
Sergio G Duron
Mark Behnke
Min Shen
Original Assignee
Afraxis Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afraxis Holdings Inc filed Critical Afraxis Holdings Inc
Publication of MA35660B1 publication Critical patent/MA35660B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Cette invention concerne des inhibiteurs de la protéine pak et des méthodes d'utilisation d'inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile.
MA37064A 2011-11-04 2014-05-26 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile MA35660B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161555902P 2011-11-04 2011-11-04
PCT/US2012/063426 WO2013067434A1 (fr) 2011-11-04 2012-11-02 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile

Publications (1)

Publication Number Publication Date
MA35660B1 true MA35660B1 (fr) 2014-11-01

Family

ID=48192852

Family Applications (2)

Application Number Title Priority Date Filing Date
MA37064A MA35660B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile
MA37065A MA35661B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA37065A MA35661B1 (fr) 2011-11-04 2014-05-26 Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire

Country Status (20)

Country Link
US (2) US20130116263A1 (fr)
EP (2) EP2773643A4 (fr)
JP (2) JP2015501786A (fr)
KR (2) KR20140096098A (fr)
CN (2) CN104093717A (fr)
AR (1) AR089175A1 (fr)
AU (2) AU2012327183A1 (fr)
BR (2) BR112014010631A2 (fr)
CA (2) CA2854471A1 (fr)
CL (2) CL2014001131A1 (fr)
CO (1) CO7030960A2 (fr)
CR (2) CR20140251A (fr)
EA (2) EA201490927A1 (fr)
IL (2) IL232154A0 (fr)
MA (2) MA35660B1 (fr)
MX (2) MX2014005296A (fr)
PH (2) PH12014500956A1 (fr)
SG (2) SG11201401996TA (fr)
TW (1) TW201326169A (fr)
WO (2) WO2013067434A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2580216A4 (fr) * 2010-06-10 2014-07-23 Afraxis Holdings Inc 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc
MX343893B (es) 2011-11-04 2016-11-28 Hoffmann La Roche Nuevos derivados de aril-quinolina.
WO2014144737A1 (fr) 2013-03-15 2014-09-18 Celgene Avilomics Research, Inc. Composés hétéroaryle et utilisations associées
CA2907243C (fr) 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Composes de dihydropyrimidopyrimidinones substitues et leurs compositions pharmaceutiques utilisees en tant qu'inhibiteur du gene fgfr4
AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
TW201516045A (zh) * 2013-07-26 2015-05-01 Hoffmann La Roche 絲胺酸／蘇胺酸激酶抑制劑
RU2721723C2 (ru) * 2014-02-07 2020-05-21 Принсипиа Биофарма, Инк. Производные хинолона как ингибиторы рецептора фактора роста фибробластов
US9828373B2 (en) 2014-07-26 2017-11-28 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof
WO2016174664A1 (fr) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Compositions à désintégration par voie orale
CA3013959C (fr) * 2016-02-17 2024-05-28 Nuralogix Corporation Systeme et procede de detection d'etat physiologique
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN109415366B (zh) * 2016-06-23 2022-02-22 豪夫迈·罗氏有限公司 [1,2,3]三唑并[4,5-d]嘧啶衍生物
WO2018013466A2 (fr) * 2016-07-15 2018-01-18 Dana-Farber Cancer Institute, Inc. Biomarqueurs prédictifs de la résistance endocrinienne dans le cancer du sein
CN106818805A (zh) * 2016-12-27 2017-06-13 东莞市联洲知识产权运营管理有限公司 一种天然乙酰胆碱酯酶抑制剂及其杀虫应用
CN107083428B (zh) * 2017-04-10 2020-09-25 徐州医科大学 Pak5在癌症诊断预后治疗及药物筛选中的应用
TWI831829B (zh) 2018-09-12 2024-02-11 美商建南德克公司 苯氧基-吡啶基-嘧啶化合物及使用方法
US20220002429A1 (en) * 2018-10-24 2022-01-06 Northwestern University Tumor cell aggregation inhibitors' for treating cancer
WO2020142612A1 (fr) * 2019-01-03 2020-07-09 Genentech, Inc. Composés de pyrido-pyrimidinone et de ptéridinone utilisés en tant qu'inhibiteurs de l'enzyme nécessitant l'inositol i (ire i alpha) à activité endoribonucléase pour le traitement de maladies cancéreuses
CN112213400B (zh) * 2019-07-09 2022-06-07 四川弘合生物科技有限公司 一种β-榄香烯及其有关物质的检测方法
CN110496128B (zh) * 2019-09-23 2022-09-30 吉林大学 利培酮或帕潘立酮在制备治疗弥漫性大b细胞淋巴瘤的药物中的应用
KR20230121758A (ko) 2020-11-18 2023-08-21 데시페라 파마슈티칼스, 엘엘씨. Gcn2 및 perk 키나제 억제제 및 그의 사용 방법
CN117858879A (zh) * 2021-01-15 2024-04-09 南京再明医药有限公司 Cdk2/4/6抑制剂及其制备方法和应用
CN113046323A (zh) * 2021-04-02 2021-06-29 四川农业大学 一种基于miR-532-5p及其靶基因调控卵巢颗粒细胞的方法
JP2024544632A (ja) 2021-12-03 2024-12-03 デシフェラ・ファーマシューティカルズ，エルエルシー Ｇｃｎ２及びｐｅｒｋキナーゼ阻害剤としての複素環式化合物
WO2025257301A1 (fr) * 2024-06-13 2025-12-18 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Traitement de la neurofibromatose de type 2 par des inhibiteurs de g6pd, acsl3 et/ou oxsm

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201765A3 (fr) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Kinases cellulaires impliqués dans l'infection par cytomégalovirus et leur inhibition
CA2668731A1 (fr) * 2006-11-09 2008-05-15 Tobias Gabriel Derives de 6-phenyl-pyrido [2,3-d] pyrimidine-7-one substitues utilises comme inhibiteurs de la kinase et methodes d'utilisation de ceux-ci
EP2112150B1 (fr) * 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
WO2010071846A2 (fr) * 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
PH12012500692A1 (en) * 2009-10-09 2012-11-12 Afraxis Inc 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders
US8912203B2 (en) * 2010-06-09 2014-12-16 Afraxis Holdings, Inc. 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders
EP2580216A4 (fr) * 2010-06-10 2014-07-23 Afraxis Holdings Inc 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles du snc

Also Published As

Publication number Publication date
PH12014500956A1 (en) 2014-06-30
BR112014010420A2 (pt) 2017-04-25
AU2012327183A1 (en) 2013-05-30
EP2773643A1 (fr) 2014-09-10
MX2014005292A (es) 2014-09-11
CL2014001132A1 (es) 2014-08-22
CA2854471A1 (fr) 2013-05-10
MX2014005296A (es) 2014-08-27
US20130116263A1 (en) 2013-05-09
CR20140250A (es) 2014-08-20
AR089175A1 (es) 2014-08-06
KR20140096098A (ko) 2014-08-04
CA2854462A1 (fr) 2013-05-10
CR20140251A (es) 2014-08-20
SG11201401914WA (en) 2014-05-29
MA35661B1 (fr) 2014-11-01
JP2015501786A (ja) 2015-01-19
SG11201401996TA (en) 2014-05-29
CN104039786A (zh) 2014-09-10
EA201490927A1 (ru) 2014-10-30
IL232154A0 (en) 2014-05-28
CL2014001131A1 (es) 2014-08-22
EA201490925A1 (ru) 2014-09-30
CN104093717A (zh) 2014-10-08
AU2012327187A1 (en) 2013-05-23
EP2773642A1 (fr) 2014-09-10
WO2013067423A1 (fr) 2013-05-10
US20150031693A1 (en) 2015-01-29
PH12014500995A1 (en) 2014-08-04
EP2773643A4 (fr) 2015-07-29
AU2012327183A8 (en) 2013-07-18
BR112014010631A2 (pt) 2017-04-25
AU2012327187A8 (en) 2013-07-25
CO7030960A2 (es) 2014-08-21
TW201326169A (zh) 2013-07-01
KR20140105451A (ko) 2014-09-01
IL232215A0 (en) 2014-06-30
WO2013067434A1 (fr) 2013-05-10
JP2014532724A (ja) 2014-12-08

Similar Documents

Publication Publication Date Title
MA35660B1 (fr) Inhibiteurs de la protéine pak pour le traitement du syndrome de l'x fragile
EA201390929A1 (ru) Антитела к pcsk9 и способы их применения
EA201391329A1 (ru) Модуляция экспрессии трансдуктора сигнала и активатора транскрипции 3 (stat3)
MA35712B1 (fr) Anticorps anti-htra1 et leurs procédés d'utilisation
EA202193044A2 (ru) Способы лечения таупатии
MA43018B1 (fr) Anticorps anti-pd1 et procédés d'utilisation
EA201170396A1 (ru) 2-оксо-1,2-дигидрохинолиновые модуляторы иммунной функции
EA201492216A1 (ru) Ингибиторы бромодомена и их применение
EA201491357A1 (ru) Анти-lrp5 антитела и способы их применения
EP2773342A4 (fr) Compositions utiles pour le traitement de maladies virales
EA201300867A1 (ru) ИНГИБИТОРЫ КИНАЗЫ mTOR В КАЧЕСТВЕ АНТИВИРУСНЫХ АГЕНТОВ
EP2773212A4 (fr) Méthodes et compositions utilisées pour le traitement de l'autisme
EP2712291A4 (fr) Inhibiteurs des sérine hydrolases de type n1- et n2-carbamoyl-1,2,3-triazole et méthodes associées
EA201490688A1 (ru) 2-тиопиримидиноны
EP2852571A4 (fr) Compositions et méthodes pour le traitement de la mucosite
EP2249789A4 (fr) Compositions et méthodes pour le traitement de la xérostomie
EP2741771A4 (fr) Méthodes et compositions pour le traitement de maladies auto-immunes et inflammatoires
IN2014CN03062A (fr)
EA201491063A1 (ru) Применение белков р3 бактериофага в качестве агентов, связывающих амилоид
UA107346C2 (en) Use of nifuratel to treat infections caused by atopobium species
EA201391199A1 (ru) Композиции из hyr1-производных и способы лечения ими
MA39347B2 (fr) Protéines de fusion d'uti
EP2678339A4 (fr) Méthodes et compositions pour le traitement de la -thalassémie et de la drépanocytose
EP2536436A4 (fr) Antimir-451 pour le traitement de polycythémies
EA201370247A1 (ru) Гипертония и гиперурикемия