CU24164B1 - Inhibidores sustituidos de acetil-coa carboxilasa - Google Patents

Inhibidores sustituidos de acetil-coa carboxilasa

Info

Publication number: CU24164B1
Authority: CU; Cuba
Prior art keywords: carboxilasa; acetil; coa; inhibitors; replaced
Prior art date: 2011-04-22

Application number

CU20130126A

Other languages

English (en)

Other versions

CU20130126A7 (es

Inventor

Robert Lee Dow

David Andrew Griffith

Jr James Alfred Southers

David James Edmonds

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-22

Filing date

2012-04-09

Publication date

2016-03-31

2012-04-09 Application filed by Pfizer filed Critical Pfizer

2014-01-29 Publication of CU20130126A7 publication Critical patent/CU20130126A7/es

2016-03-31 Publication of CU24164B1 publication Critical patent/CU24164B1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Photographic Processing Devices Using Wet Methods (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

CU20130126A 2011-04-22 2012-04-09 Inhibidores sustituidos de acetil-coa carboxilasa CU24164B1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161478240P	2011-04-22	2011-04-22
PCT/IB2012/051732 WO2012143813A1 (en)	2011-04-22	2012-04-09	Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors

Publications (2)

Publication Number	Publication Date
CU20130126A7 CU20130126A7 (es)	2014-01-29
CU24164B1 true CU24164B1 (es)	2016-03-31

Family

ID=46025823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CU20130126A CU24164B1 (es)	2011-04-22	2012-04-09	Inhibidores sustituidos de acetil-coa carboxilasa

Country Status (43)

Country	Link
US (4)	US8802688B2 (es)
EP (1)	EP2699576B1 (es)
JP (1)	JP5657174B2 (es)
KR (1)	KR101567659B1 (es)
CN (2)	CN106117205B (es)
AP (1)	AP3499A (es)
AR (1)	AR086198A1 (es)
AU (1)	AU2012245996B2 (es)
CA (1)	CA2831380C (es)
CL (1)	CL2013002794A1 (es)
CO (1)	CO6801757A2 (es)
CR (1)	CR20130464A (es)
CU (1)	CU24164B1 (es)
CY (1)	CY1117122T1 (es)
DK (1)	DK2699576T3 (es)
DO (1)	DOP2013000243A (es)
EA (1)	EA022375B1 (es)
EC (1)	ECSP13013038A (es)
ES (1)	ES2561452T3 (es)
GE (1)	GEP20166474B (es)
GT (1)	GT201300258A (es)
HR (1)	HRP20151397T1 (es)
HU (1)	HUE028602T2 (es)
IL (1)	IL228949A (es)
MA (1)	MA35061B1 (es)
ME (1)	ME02312B (es)
MX (1)	MX348860B (es)
MY (1)	MY162167A (es)
NI (1)	NI201300111A (es)
NZ (1)	NZ616156A (es)
PE (1)	PE20141187A1 (es)
PH (1)	PH12013501941A1 (es)
PL (1)	PL2699576T3 (es)
PT (1)	PT2699576E (es)
PY (1)	PY1218709A (es)
RS (1)	RS54526B1 (es)
SG (1)	SG194142A1 (es)
SI (1)	SI2699576T1 (es)
TN (1)	TN2013000393A1 (es)
TW (1)	TWI464171B (es)
UA (1)	UA107753C2 (es)
UY (1)	UY34027A (es)
WO (1)	WO2012143813A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2947082A1 (en) *	2009-11-10	2015-11-25	Pfizer Inc	N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
CN102491974B (zh) *	2011-12-12	2013-08-07	南京药石药物研发有限公司	1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
US9447026B2 (en)	2013-03-14	2016-09-20	Kalyra Pharmaceuticals, Inc.	Bicyclic analgesic compounds
EP2994139B1 (en)	2013-05-10	2019-04-10	Gilead Apollo, LLC	Acc inhibitors and uses thereof
AU2014262547A1 (en)	2013-05-10	2015-11-26	Gilead Apollo, Llc	ACC inhibitors and uses thereof
JP6417401B2 (ja) *	2013-05-10	2018-11-07	ギリアドアポロ，エルエルシー	Ａｃｃ阻害剤及びその使用
US20160220557A1 (en) *	2013-09-12	2016-08-04	Pfizer Inc.	Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris
EP3670496A3 (en)	2013-10-17	2020-09-30	Shionogi&Co., Ltd.	Acc2 inhibitors
CA2932039A1 (en) *	2013-12-12	2015-06-18	Kalyra Pharmaceuticals, Inc.	Bicyclic alkyl compounds and synthesis
CN113336653A (zh)	2014-03-07	2021-09-03	里科瑞尔姆Ip控股有限责任公司	螺桨烷衍生物及合成
CA2892342C (en)	2014-05-22	2016-11-01	Sylvain-Paul Morency	Tool and method for layer depalletizing
US10308609B2 (en)	2014-09-17	2019-06-04	Zeno Royalties & Milestones, LLC	Bicyclic compounds
AU2016383376B2 (en) *	2015-12-31	2022-07-28	Beijing Gushen Life Health Technology Co., Ltd.	Triacetyl-3-hydroxyphenyladenosine and application in preparing pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease
CN106580986B (zh) *	2016-11-28	2017-09-15	王保亮	一种治疗少弱精子症的药物组合物
US11242327B2 (en)	2017-05-15	2022-02-08	Recurium Ip Holdings, Llc	Analgesic compounds
CN111406056B (zh)	2017-11-21	2023-02-28	辉瑞公司	选择性acc抑制剂的结晶2-氨基-2-(羟甲基)丙烷-1,3-二醇盐
LT3796975T (lt)	2018-05-22	2023-12-11	Orsobio, Inc.	Sulfonilaminobenzamido dariniai
CN111574530B (zh) *	2020-04-21	2022-07-26	徐州医科大学	一种acc抑制剂及其医药用途
CN120457124A (zh) *	2022-12-30	2025-08-08	苏州浦合医药科技有限公司	Prmt5-mta抑制剂
CN121241054A (zh) *	2023-04-14	2025-12-30	北京双鹤润创科技有限公司	氮杂环羰基稠环衍生物及其用途
CN121909191A (zh) *	2023-08-16	2026-04-21	智擎生技制药股份有限公司	Mta协同性的prmt5抑制剂

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2287971T3 (es)	1997-08-11	2007-12-16	Pfizer Products Inc.	Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
CA2439152C (en)	2001-02-28	2008-06-17	Merck & Co., Inc.	Acylated piperidine derivatives as melanocortin-4 receptor agonists
CN1642599A (zh)	2002-02-27	2005-07-20	辉瑞产品公司	Acc抑制剂
US7105526B2 (en)	2002-06-28	2006-09-12	Banyu Pharmaceuticals Co., Ltd.	Benzimidazole derivatives
WO2004092179A1 (ja)	2003-04-14	2004-10-28	Nippon Soda Co. Ltd.	スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja)	2003-10-15	2005-05-12	Ajinomoto Co Inc	アシルスルホンアミド誘導体
PL1753748T3 (pl)	2004-05-12	2010-01-29	Pfizer Prod Inc	Pochodne proliny i ich zastosowanie jako inhibitorów peptydazy dipeptylowej IV
WO2005113069A2 (en)	2004-05-14	2005-12-01	Research Development Foundation	Use of circumin and analogues as inhibitors of acc2
AP2006003768A0 (en)	2004-05-25	2006-10-31	Pfizer Prod Inc	TetraazabenzoÄeÜazulene derivatives and analogs tehereof
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
WO2007011809A1 (en)	2005-07-19	2007-01-25	Merck & Co., Inc.	Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
CA2617042A1 (en)	2005-07-29	2007-02-01	Takeda Pharmaceutical Company Limited	Spiro-cyclic compound
JP2009515971A (ja)	2005-11-18	2009-04-16	メルクエンドカムパニーインコーポレーテッド	スピロヒダントインアリールｃｇｒｐ受容体アンタゴニスト
JP2009526868A (ja)	2006-02-15	2009-07-23	アボット・ラボラトリーズ	新規なアセチル−ＣｏＡカルボキシラーゼ（ＡＣＣ）阻害薬およびこれらの糖尿病、肥満および代謝症候群における使用
EP2010520B1 (en)	2006-04-20	2012-09-12	Pfizer Products Inc.	Heterobicyclic amides for the prevention and treatment of glucokinase-mediated diseases
BRPI0721053A2 (pt)	2006-11-29	2014-07-29	Pfizer Prod Inc	INIBIDORES DE ESPIROCETONA ACETIL-CoA CARBOXILASE
PE20081559A1 (es)	2007-01-12	2008-11-20	Merck & Co Inc	DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
JPWO2008102749A1 (ja) *	2007-02-20	2010-05-27	武田薬品工業株式会社	複素環化合物
AU2008237660B2 (en)	2007-04-12	2011-12-22	Pfizer Inc.	3-amido-pyrrolo [3, 4-C] pyrazole-5 (1H, 4H, 6H) carbaldehyde derivatives as inhibitors of protein kinase C
US20090036425A1 (en)	2007-08-02	2009-02-05	Pfizer Inc	Substituted bicyclolactam compounds
US7981904B2 (en)	2008-03-20	2011-07-19	Takeda Pharmaceutical Company Limited	Acetyl CoA carboxylase inhibitors
WO2009144555A1 (en)	2008-05-28	2009-12-03	Pfizer Inc.	Pyrazolospiroketone acetyl-coa carboxylase inhibitors
JP5435592B2 (ja) *	2008-05-28	2014-03-05	ファイザー・インク	ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
WO2010002010A1 (en) *	2008-07-04	2010-01-07	Banyu Pharmaceutical Co.,Ltd.	Novel spirochromanone carboxylic acids
AU2009271634A1 (en)	2008-07-14	2010-01-21	Cropsolution, Inc.	Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
JP2011529483A (ja)	2008-07-29	2011-12-08	ファイザー・インク	フッ素化ヘテロアリール
AU2009286380B2 (en)	2008-08-28	2011-09-15	Pfizer Inc.	Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives
TW201038580A (en)	2009-02-02	2010-11-01	Pfizer	4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives
EP2604604A1 (en)	2009-03-11	2013-06-19	Pfizer Inc	Benzofuranyl derivatives used as glucokinase inhibitors
CA2754685A1 (en)	2009-03-11	2010-09-16	Pfizer Inc.	Substituted indazole amides
WO2010106457A2 (en)	2009-03-20	2010-09-23	Pfizer Inc.	3-oxa-7-azabicyclo[3.3.1]nonanes
US20120052130A1 (en)	2009-05-08	2012-03-01	Pfizer Inc.	Gpr 119 modulators
CA2759843A1 (en)	2009-05-08	2010-11-10	Pfizer Inc.	Gpr 119 modulators
NZ596467A (en)	2009-06-05	2014-01-31	Pfizer	L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators
WO2011005611A1 (en)	2009-07-09	2011-01-13	Merck Sharp & Dohme Corp.	Neuromedin u receptor agonists and uses thereof
EP2499140A1 (en) *	2009-11-10	2012-09-19	Pfizer Inc.	N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors
EP2947082A1 (en) *	2009-11-10	2015-11-25	Pfizer Inc	N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
HRP20161178T1 (hr) *	2010-09-30	2016-11-04	Pfizer Inc.	N1-PIRAZOLOSPIROKETONSKI INHIBITORI ACETIL-CoA-KARBOKSILAZE

2012
- 2012-04-09 AU AU2012245996A patent/AU2012245996B2/en not_active Ceased
- 2012-04-09 MY MYPI2013003372A patent/MY162167A/en unknown
- 2012-04-09 PH PH1/2013/501941A patent/PH12013501941A1/en unknown
- 2012-04-09 NZ NZ616156A patent/NZ616156A/en not_active IP Right Cessation
- 2012-04-09 DK DK12718387.9T patent/DK2699576T3/en active
- 2012-04-09 ES ES12718387.9T patent/ES2561452T3/es active Active
- 2012-04-09 KR KR1020137030875A patent/KR101567659B1/ko not_active Expired - Fee Related
- 2012-04-09 PL PL12718387T patent/PL2699576T3/pl unknown
- 2012-04-09 HR HRP20151397TT patent/HRP20151397T1/hr unknown
- 2012-04-09 AP AP2013007129A patent/AP3499A/xx active
- 2012-04-09 PT PT127183879T patent/PT2699576E/pt unknown
- 2012-04-09 SG SG2013075148A patent/SG194142A1/en unknown
- 2012-04-09 ME MEP-2015-214A patent/ME02312B/me unknown
- 2012-04-09 CN CN201610487378.8A patent/CN106117205B/zh not_active Expired - Fee Related
- 2012-04-09 MX MX2013012313A patent/MX348860B/es active IP Right Grant
- 2012-04-09 SI SI201230417T patent/SI2699576T1/sl unknown
- 2012-04-09 HU HUE12718387A patent/HUE028602T2/hu unknown
- 2012-04-09 WO PCT/IB2012/051732 patent/WO2012143813A1/en not_active Ceased
- 2012-04-09 GE GEAP201213267A patent/GEP20166474B/en unknown
- 2012-04-09 CN CN201280019621.3A patent/CN103492388A/zh active Pending
- 2012-04-09 EA EA201391288A patent/EA022375B1/ru not_active IP Right Cessation
- 2012-04-09 RS RS20160026A patent/RS54526B1/sr unknown
- 2012-04-09 CA CA2831380A patent/CA2831380C/en active Active
- 2012-04-09 EP EP12718387.9A patent/EP2699576B1/en active Active
- 2012-04-09 PE PE2013002387A patent/PE20141187A1/es not_active Application Discontinuation
- 2012-04-09 MA MA36357A patent/MA35061B1/fr unknown
- 2012-04-09 CU CU20130126A patent/CU24164B1/es active IP Right Grant
- 2012-04-09 JP JP2014505745A patent/JP5657174B2/ja active Active
- 2012-04-18 TW TW101113766A patent/TWI464171B/zh not_active IP Right Cessation
- 2012-04-19 UY UY0001034027A patent/UY34027A/es not_active Application Discontinuation
- 2012-04-20 PY PY201201218709A patent/PY1218709A/es unknown
- 2012-04-20 AR ARP120101364A patent/AR086198A1/es unknown
- 2012-04-21 US US13/452,839 patent/US8802688B2/en active Active
- 2012-09-04 UA UAA201311822A patent/UA107753C2/ru unknown
2013
- 2013-09-12 CR CR20130464A patent/CR20130464A/es unknown
- 2013-09-27 TN TNP2013000393A patent/TN2013000393A1/fr unknown
- 2013-09-27 CL CL2013002794A patent/CL2013002794A1/es unknown
- 2013-10-17 IL IL228949A patent/IL228949A/en active IP Right Grant
- 2013-10-18 NI NI201300111A patent/NI201300111A/es unknown
- 2013-10-18 GT GT201300258A patent/GT201300258A/es unknown
- 2013-10-21 DO DO2013000243A patent/DOP2013000243A/es unknown
- 2013-10-24 CO CO13252716A patent/CO6801757A2/es active IP Right Grant
- 2013-11-22 EC ECSP13013038 patent/ECSP13013038A/es unknown
2014
- 2014-07-08 US US14/325,420 patent/US20140323730A1/en not_active Abandoned
2015
- 2015-01-09 US US14/593,370 patent/US20150112068A1/en not_active Abandoned
- 2015-08-07 US US14/820,884 patent/US20150336958A1/en not_active Abandoned
2016
- 2016-01-14 CY CY20161100038T patent/CY1117122T1/el unknown

Also Published As

Publication number	Publication date
AR086198A1 (es)	2013-11-27
EA201391288A1 (ru)	2014-04-30
PL2699576T3 (pl)	2016-05-31
TW201305162A (zh)	2013-02-01
PT2699576E (pt)	2016-03-09
CN103492388A (zh)	2014-01-01
DOP2013000243A (es)	2013-12-31
CN106117205A (zh)	2016-11-16
CA2831380C (en)	2016-04-05
MX2013012313A (es)	2014-01-31
CO6801757A2 (es)	2013-11-29
TN2013000393A1 (fr)	2015-01-20
US8802688B2 (en)	2014-08-12
CL2013002794A1 (es)	2013-12-27
CU20130126A7 (es)	2014-01-29
AP2013007129A0 (en)	2013-09-30
AU2012245996A1 (en)	2013-10-03
KR101567659B1 (ko)	2015-11-09
US20120270893A1 (en)	2012-10-25
NZ616156A (en)	2014-08-29
MX348860B (es)	2017-06-30
SG194142A1 (en)	2013-11-29
US20150112068A1 (en)	2015-04-23
HUE028602T2 (hu)	2016-12-28
EP2699576A1 (en)	2014-02-26
EA022375B1 (ru)	2015-12-30
CY1117122T1 (el)	2017-04-05
AP3499A (en)	2015-12-31
PE20141187A1 (es)	2014-09-18
PH12013501941A1 (en)	2021-06-23
UA107753C2 (xx)	2015-02-10
PY1218709A (es)	2016-01-01
US20150336958A1 (en)	2015-11-26
AU2012245996B2 (en)	2016-09-01
DK2699576T3 (en)	2016-02-15
UY34027A (es)	2013-04-05
JP5657174B2 (ja)	2015-01-21
ES2561452T3 (es)	2016-02-26
HRP20151397T1 (hr)	2016-01-15
MA35061B1 (fr)	2014-04-03
MY162167A (en)	2017-05-31
SI2699576T1 (sl)	2016-02-29
GEP20166474B (en)	2016-05-10
NI201300111A (es)	2014-02-12
US20140323730A1 (en)	2014-10-30
GT201300258A (es)	2015-06-02
WO2012143813A1 (en)	2012-10-26
IL228949A0 (en)	2013-12-31
EP2699576B1 (en)	2015-12-09
RS54526B1 (sr)	2016-06-30
KR20140015511A (ko)	2014-02-06
TWI464171B (zh)	2014-12-11
JP2014515755A (ja)	2014-07-03
CN106117205B (zh)	2018-09-21
ECSP13013038A (es)	2014-01-31
ME02312B (me)	2016-06-20
CA2831380A1 (en)	2012-10-26
IL228949A (en)	2016-11-30
CR20130464A (es)	2013-10-16

Legal Events

Date	Code	Title	Description
2016-02-18	FG	Grant of patent

Publication	Publication Date	Title
CU24164B1 (es)	2016-03-31	Inhibidores sustituidos de acetil-coa carboxilasa
HRP20181786T1 (hr)	2019-02-08	Inhibitori aktivacije t-stanica
EP2734529A4 (en)	2015-06-03	BTK INHIBITORS
DK2744810T4 (da)	2023-11-20	Tenofovir-alafenamid-hemifumarat
EP2715659A4 (en)	2014-11-12	ABOUT FEED
DK2769050T3 (da)	2021-05-17	Propsensor
DE102011100082A8 (de)	2013-01-10	Traygreifvorrichtung
EP2752374A4 (en)	2015-09-16	gooseneck
EP2795884A4 (en)	2015-07-29	Audio conferencing
BR112014000879A2 (pt)	2017-02-21	deflegmador
DK3272861T3 (da)	2020-03-23	Alpha-galactosidase-sammensætninger
EP2701512A4 (en)	2014-11-26	Aldosterone synthase inhibitors
CO6960543A2 (es)	2014-05-30	2-tiopirimidinonas
EP2786752A4 (en)	2015-05-06	Ropinirole-containing adhesive patch
EP2723481A4 (en)	2014-12-17	FLOW COMPENSATOR
DK3141251T3 (da)	2021-02-01	Koloskopi - forberedelse
EP2708561A4 (en)	2014-09-24	BIO-PIN
EP2715068A4 (en)	2015-12-02	Tunneling apparatus
EP2695208A4 (en)	2014-12-31	MICRO THERMOCOUPLE
EP2738148A4 (en)	2015-05-27	RECIPROCAL LOCKING BLOCK
EP2762923A4 (en)	2015-10-21	RADIATION MEASURING DEVICE
DE112011104936A5 (de)	2013-11-28	Stanzstauchniet
EP2760803A4 (en)	2015-07-08	Geopolymer product
EP2694057A4 (en)	2014-10-08	LIPOXYGENASE INHIBITORS
DE112012000958A5 (de)	2013-11-28	Handsäge