CR20140593A - N-[4-(quinolin-4-iloxi)ciclohexil (metil)](hetero) aril-carboxamidas como antagonistas del receptor de andrógenos, su producción y usos como productos medicinales - Google Patents

N-[4-(quinolin-4-iloxi)ciclohexil (metil)](hetero) aril-carboxamidas como antagonistas del receptor de andrógenos, su producción y usos como productos medicinales

Info

Publication number
CR20140593A
CR20140593A CR20140593A CR20140593A CR20140593A CR 20140593 A CR20140593 A CR 20140593A CR 20140593 A CR20140593 A CR 20140593A CR 20140593 A CR20140593 A CR 20140593A CR 20140593 A CR20140593 A CR 20140593A
Authority
CR
Costa Rica
Prior art keywords
quinolin
methyl
production
cyclohexil
carboxamids
Prior art date
Application number
CR20140593A
Other languages
English (en)
Inventor
Duy Nguyen
Hermann Künzer
Gimenez Hortensia Faus
Benjamin Bader
Silke Köhr
Martin Fritsch
Original Assignee
Bayer Pharma AG
Bayer Shering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48699019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140593(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG, Bayer Shering Pharma Ag filed Critical Bayer Pharma AG
Publication of CR20140593A publication Critical patent/CR20140593A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

La invención se relaciona con N-[4-(quinolin-4-iloxi)ciclohexil (metil)](hetero)arilcarboxamidas, intermediarios y métodos para su producción, uso de las mismas para tratar y/o prevenir enfermedades y uso de las mismas para producir productos medicinales y uso de los mismos para tratar y/o prevenir enfermedades, en especial enfermedades hiperproliferativas.
CR20140593A 2012-06-26 2014-12-18 N-[4-(quinolin-4-iloxi)ciclohexil (metil)](hetero) aril-carboxamidas como antagonistas del receptor de andrógenos, su producción y usos como productos medicinales CR20140593A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12004764 2012-06-26
PCT/EP2013/063118 WO2014001247A1 (en) 2012-06-26 2013-06-24 N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products

Publications (1)

Publication Number Publication Date
CR20140593A true CR20140593A (es) 2015-02-16

Family

ID=48699019

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20140593A CR20140593A (es) 2012-06-26 2014-12-18 N-[4-(quinolin-4-iloxi)ciclohexil (metil)](hetero) aril-carboxamidas como antagonistas del receptor de andrógenos, su producción y usos como productos medicinales

Country Status (40)

Country Link
US (1) US9428460B2 (es)
EP (1) EP2864291B1 (es)
JP (1) JP6181172B2 (es)
KR (1) KR20150023880A (es)
AP (1) AP3919A (es)
AR (1) AR091565A1 (es)
AU (1) AU2013283543B2 (es)
BR (1) BR112014032538A2 (es)
CA (1) CA2877786C (es)
CL (1) CL2014003443A1 (es)
CO (1) CO7170167A2 (es)
CR (1) CR20140593A (es)
CU (1) CU20140144A7 (es)
CY (1) CY1118412T1 (es)
DK (1) DK2864291T3 (es)
DO (1) DOP2014000295A (es)
EA (1) EA028063B1 (es)
EC (1) ECSP14032516A (es)
ES (1) ES2609455T3 (es)
HR (1) HRP20161745T1 (es)
HU (1) HUE032306T2 (es)
IL (1) IL236146B (es)
JO (1) JO3342B1 (es)
LT (1) LT2864291T (es)
MA (1) MA37700B1 (es)
ME (1) ME02590B (es)
MX (1) MX2014016054A (es)
NZ (1) NZ703100A (es)
PE (1) PE20150154A1 (es)
PH (1) PH12014502869A1 (es)
PL (1) PL2864291T3 (es)
PT (1) PT2864291T (es)
RS (1) RS55500B1 (es)
SG (1) SG11201408254UA (es)
SI (1) SI2864291T1 (es)
TN (1) TN2014000532A1 (es)
TW (1) TWI600646B (es)
UA (1) UA115447C2 (es)
UY (1) UY34881A (es)
WO (1) WO2014001247A1 (es)

Families Citing this family (5)

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CN106413715A (zh) * 2014-04-22 2017-02-15 林伯士艾瑞斯公司 Irak抑制剂和其用途
UY36391A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
KR20190004742A (ko) * 2016-05-04 2019-01-14 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
US10544099B2 (en) 2016-05-04 2020-01-28 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use

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US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1296953A2 (en) 2000-06-23 2003-04-02 Eli Lilly And Company Methods and compounds for inhibiting mrp1
EP2088141A3 (en) 2001-06-22 2009-11-18 Kirin Pharma Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives capable of inhibiting autophosphorylation of hepatocyte growth factor receptors, and pharmaceutical composition comprising the same
EP1550657A4 (en) 2002-09-11 2009-12-30 Kureha Corp AMINO COMPOUNDS AND THEIR USE
US20050227932A1 (en) 2002-11-13 2005-10-13 Tianbao Lu Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction
DE602004022633D1 (de) 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
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JP2007529511A (ja) 2004-03-17 2007-10-25 グラクソ　グループ　リミテッド Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト
SE0401342D0 (sv) 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
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JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
GB0509224D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of intracellular enzymatic activity
GB0509227D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Intracellular enzyme inhibitors
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EP1981492A1 (en) 2006-02-06 2008-10-22 Showa Denko K.K. Whitening dermatological preparations
CA2655128A1 (en) 2006-06-08 2007-12-21 Array Biopharma Inc. Quinoline compounds and methods of use
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
WO2008064432A1 (en) 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds
JP5634263B2 (ja) 2007-08-16 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング キナゾリンジオンキマーゼ阻害剤
CA2966280A1 (en) * 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
MX2010012290A (es) 2008-05-14 2011-02-21 Amgen Inc Combinaciones de inhibidores del receptor del factor de crecimiento endotelial vascular e inhibidores del factor de crecimiento de hepatocito para el tratamiento de cancer.
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WO2012009649A1 (en) 2010-07-16 2012-01-19 Anderson Gaweco Mif inhibitors and their uses

Also Published As

Publication number Publication date
AR091565A1 (es) 2015-02-11
HUE032306T2 (en) 2017-09-28
IL236146A0 (en) 2015-02-01
CU20140144A7 (es) 2015-08-27
PL2864291T3 (pl) 2017-07-31
US9428460B2 (en) 2016-08-30
ES2609455T3 (es) 2017-04-20
NZ703100A (en) 2016-10-28
PH12014502869B1 (en) 2015-02-23
EP2864291B1 (en) 2016-10-05
CA2877786A1 (en) 2014-01-03
PT2864291T (pt) 2017-01-06
JP6181172B2 (ja) 2017-08-16
AU2013283543B2 (en) 2017-11-02
US20150191431A1 (en) 2015-07-09
PH12014502869A1 (en) 2015-02-23
DOP2014000295A (es) 2015-01-31
CA2877786C (en) 2020-08-25
SI2864291T1 (sl) 2017-01-31
TW201400460A (zh) 2014-01-01
WO2014001247A1 (en) 2014-01-03
CN104684896A (zh) 2015-06-03
MA20150269A1 (fr) 2015-08-31
RS55500B1 (sr) 2017-05-31
UY34881A (es) 2014-01-31
MA37700B1 (fr) 2018-03-30
LT2864291T (lt) 2017-01-10
MX2014016054A (es) 2015-04-10
EA028063B1 (ru) 2017-10-31
PE20150154A1 (es) 2015-02-19
CO7170167A2 (es) 2015-01-28
EA201500039A1 (ru) 2015-06-30
CL2014003443A1 (es) 2015-06-26
TWI600646B (zh) 2017-10-01
JP2015521641A (ja) 2015-07-30
DK2864291T3 (en) 2017-01-16
AP2014008141A0 (en) 2014-12-31
CY1118412T1 (el) 2017-06-28
TN2014000532A1 (en) 2016-03-30
AP3919A (en) 2016-11-30
ME02590B (me) 2017-06-20
HK1206346A1 (en) 2016-01-08
IL236146B (en) 2018-05-31
AU2013283543A1 (en) 2015-01-29
SG11201408254UA (en) 2015-01-29
HRP20161745T1 (hr) 2017-02-24
ECSP14032516A (es) 2015-12-31
EP2864291A1 (en) 2015-04-29
BR112014032538A2 (pt) 2017-06-27
KR20150023880A (ko) 2015-03-05
JO3342B1 (ar) 2019-03-13
UA115447C2 (uk) 2017-11-10

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