MA37700B1 - N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments - Google Patents
N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicamentsInfo
- Publication number
- MA37700B1 MA37700B1 MA37700A MA37700A MA37700B1 MA 37700 B1 MA37700 B1 MA 37700B1 MA 37700 A MA37700 A MA 37700A MA 37700 A MA37700 A MA 37700A MA 37700 B1 MA37700 B1 MA 37700B1
- Authority
- MA
- Morocco
- Prior art keywords
- arylcarboxamides
- quinolin
- yloxy
- hetero
- cyclohexyl
- Prior art date
Links
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 125000005842 heteroatom Chemical group 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 2
- -1 quinolin-4-yloxy Chemical group 0.000 title abstract 2
- 229940123407 Androgen receptor antagonist Drugs 0.000 title 1
- 239000003936 androgen receptor antagonist Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
La présente invention concerne les n-[4-(quinolin-4-yloxy)cyclohexyl (méthyl)](hétéro)arylcarboxamides, leurs intermédiaires et leurs procédés de production, leur utilisation pour traiter et/ou prévenir des maladies et leur utilisation en vue de la production de médicaments, ainsi que l'utilisation de ces derniers en vue du traitement et/ou de la prévention de maladies, dont, plus particulièrement, les maladies hyperprolifératives.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12004764 | 2012-06-26 | ||
| PCT/EP2013/063118 WO2014001247A1 (fr) | 2012-06-26 | 2013-06-24 | N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA20150269A1 MA20150269A1 (fr) | 2015-08-31 |
| MA37700B1 true MA37700B1 (fr) | 2018-03-30 |
Family
ID=48699019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37700A MA37700B1 (fr) | 2012-06-26 | 2013-06-24 | N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9428460B2 (fr) |
| EP (1) | EP2864291B1 (fr) |
| JP (1) | JP6181172B2 (fr) |
| KR (1) | KR20150023880A (fr) |
| AP (1) | AP3919A (fr) |
| AR (1) | AR091565A1 (fr) |
| AU (1) | AU2013283543B2 (fr) |
| BR (1) | BR112014032538A2 (fr) |
| CA (1) | CA2877786C (fr) |
| CL (1) | CL2014003443A1 (fr) |
| CO (1) | CO7170167A2 (fr) |
| CR (1) | CR20140593A (fr) |
| CU (1) | CU20140144A7 (fr) |
| CY (1) | CY1118412T1 (fr) |
| DK (1) | DK2864291T3 (fr) |
| DO (1) | DOP2014000295A (fr) |
| EA (1) | EA028063B1 (fr) |
| EC (1) | ECSP14032516A (fr) |
| ES (1) | ES2609455T3 (fr) |
| HR (1) | HRP20161745T1 (fr) |
| HU (1) | HUE032306T2 (fr) |
| IL (1) | IL236146B (fr) |
| JO (1) | JO3342B1 (fr) |
| LT (1) | LT2864291T (fr) |
| MA (1) | MA37700B1 (fr) |
| ME (1) | ME02590B (fr) |
| MX (1) | MX2014016054A (fr) |
| NZ (1) | NZ703100A (fr) |
| PE (1) | PE20150154A1 (fr) |
| PH (1) | PH12014502869A1 (fr) |
| PL (1) | PL2864291T3 (fr) |
| PT (1) | PT2864291T (fr) |
| RS (1) | RS55500B1 (fr) |
| SG (1) | SG11201408254UA (fr) |
| SI (1) | SI2864291T1 (fr) |
| TN (1) | TN2014000532A1 (fr) |
| TW (1) | TWI600646B (fr) |
| UA (1) | UA115447C2 (fr) |
| UY (1) | UY34881A (fr) |
| WO (1) | WO2014001247A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106413715A (zh) * | 2014-04-22 | 2017-02-15 | 林伯士艾瑞斯公司 | Irak抑制剂和其用途 |
| UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| KR20190004742A (ko) * | 2016-05-04 | 2019-01-14 | 브리스톨-마이어스 스큅 컴퍼니 | 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법 |
| US10544099B2 (en) | 2016-05-04 | 2020-01-28 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328821A (en) | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| EP1296953A2 (fr) | 2000-06-23 | 2003-04-02 | Eli Lilly And Company | Procedes et composes d'inhibition du mrp1 |
| EP2088141A3 (fr) | 2001-06-22 | 2009-11-18 | Kirin Pharma Kabushiki Kaisha | Dérivés de quinoline et de quinazoline capables d'inhiber l'autophosphorylation des récepteurs du facteur de croissance des hépatocytes et composition pharmaceutique les comprenant |
| EP1550657A4 (fr) | 2002-09-11 | 2009-12-30 | Kureha Corp | Composes amines et leurs utilisation |
| US20050227932A1 (en) | 2002-11-13 | 2005-10-13 | Tianbao Lu | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction |
| DE602004022633D1 (de) | 2003-01-30 | 2009-10-01 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| JP2007529511A (ja) | 2004-03-17 | 2007-10-25 | グラクソ グループ リミテッド | Ｍ３ムスカリン性アセチルコリン受容体アンタゴニスト |
| SE0401342D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
| WO2005117570A1 (fr) | 2004-05-27 | 2005-12-15 | Jack Saffron | Coupelle pour aliments empechant l'infestation par des parasites |
| WO2006052722A1 (fr) | 2004-11-09 | 2006-05-18 | Smithkline Beecham Corporation | Composes inhibiteurs de la phosphorylase du glycogene et compositions pharmaceutiques les comprenant |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0509224D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of intracellular enzymatic activity |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| US20060293341A1 (en) | 2005-06-23 | 2006-12-28 | Vrej Jubian | Alkyl sulfonamide derivatives |
| EP1981492A1 (fr) | 2006-02-06 | 2008-10-22 | Showa Denko K.K. | Préparations dermatologiques de blanchiment |
| CA2655128A1 (fr) | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinolines et methodes d'utilisation |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2008064432A1 (fr) | 2006-12-01 | 2008-06-05 | The University Of Sydney | Composés moléculaires polycycliques |
| JP5634263B2 (ja) | 2007-08-16 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナゾリンジオンキマーゼ阻害剤 |
| CA2966280A1 (fr) * | 2007-10-26 | 2009-04-30 | The Regents Of The University Of California | Composes de diaryl-hydantoine |
| MX2010012290A (es) | 2008-05-14 | 2011-02-21 | Amgen Inc | Combinaciones de inhibidores del receptor del factor de crecimiento endotelial vascular e inhibidores del factor de crecimiento de hepatocito para el tratamiento de cancer. |
| AU2009300328A1 (en) | 2008-10-01 | 2010-04-08 | Ludwig Institute For Cancer Research | Methods for the treatment of cancer |
| AU2010276441B2 (en) | 2009-07-21 | 2015-07-02 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| US20120238533A1 (en) | 2009-09-11 | 2012-09-20 | Bayer Pharma Aktiengesellschaft | (Heteroarylmethyl) Thiohydantoins as anticancer drugs |
| WO2012009649A1 (fr) | 2010-07-16 | 2012-01-19 | Anderson Gaweco | Inhibiteurs mif et leurs utilisations |
-
2013
- 2013-06-24 LT LTEP13731325.0T patent/LT2864291T/lt unknown
- 2013-06-24 JP JP2015519023A patent/JP6181172B2/ja not_active Expired - Fee Related
- 2013-06-24 EA EA201500039A patent/EA028063B1/ru not_active IP Right Cessation
- 2013-06-24 AU AU2013283543A patent/AU2013283543B2/en not_active Ceased
- 2013-06-24 AP AP2014008141A patent/AP3919A/en active
- 2013-06-24 ME MEP-2016-292A patent/ME02590B/fr unknown
- 2013-06-24 EP EP13731325.0A patent/EP2864291B1/fr active Active
- 2013-06-24 WO PCT/EP2013/063118 patent/WO2014001247A1/fr not_active Ceased
- 2013-06-24 JO JOP/2013/0192A patent/JO3342B1/ar active
- 2013-06-24 SG SG11201408254UA patent/SG11201408254UA/en unknown
- 2013-06-24 HU HUE13731325A patent/HUE032306T2/en unknown
- 2013-06-24 CA CA2877786A patent/CA2877786C/fr not_active Expired - Fee Related
- 2013-06-24 MA MA37700A patent/MA37700B1/fr unknown
- 2013-06-24 NZ NZ703100A patent/NZ703100A/en not_active IP Right Cessation
- 2013-06-24 BR BR112014032538A patent/BR112014032538A2/pt not_active Application Discontinuation
- 2013-06-24 PE PE2014002495A patent/PE20150154A1/es active IP Right Grant
- 2013-06-24 UA UAA201500561A patent/UA115447C2/uk unknown
- 2013-06-24 KR KR20157001996A patent/KR20150023880A/ko not_active Ceased
- 2013-06-24 PT PT137313250T patent/PT2864291T/pt unknown
- 2013-06-24 MX MX2014016054A patent/MX2014016054A/es unknown
- 2013-06-24 US US14/408,876 patent/US9428460B2/en not_active Expired - Fee Related
- 2013-06-24 RS RS20161149A patent/RS55500B1/sr unknown
- 2013-06-24 ES ES13731325.0T patent/ES2609455T3/es active Active
- 2013-06-24 SI SI201330440A patent/SI2864291T1/sl unknown
- 2013-06-24 DK DK13731325.0T patent/DK2864291T3/en active
- 2013-06-24 HR HRP20161745TT patent/HRP20161745T1/hr unknown
- 2013-06-24 PL PL13731325T patent/PL2864291T3/pl unknown
- 2013-06-26 UY UY0001034881A patent/UY34881A/es not_active Application Discontinuation
- 2013-06-26 TW TW102122775A patent/TWI600646B/zh not_active IP Right Cessation
- 2013-06-26 AR ARP130102253 patent/AR091565A1/es unknown
-
2014
- 2014-12-09 IL IL236146A patent/IL236146B/en active IP Right Grant
- 2014-12-18 CR CR20140593A patent/CR20140593A/es unknown
- 2014-12-18 CL CL2014003443A patent/CL2014003443A1/es unknown
- 2014-12-18 CU CUP2014000144A patent/CU20140144A7/es unknown
- 2014-12-19 CO CO14279115A patent/CO7170167A2/es unknown
- 2014-12-19 DO DO2014000295A patent/DOP2014000295A/es unknown
- 2014-12-19 EC ECIEPI201432516A patent/ECSP14032516A/es unknown
- 2014-12-22 PH PH12014502869A patent/PH12014502869A1/en unknown
- 2014-12-25 TN TN2014000532A patent/TN2014000532A1/fr unknown
-
2016
- 2016-12-23 CY CY20161101343T patent/CY1118412T1/el unknown
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