RS55500B1 - N-[4-(hinolin-4-iloksi)cikloheksil(metil)](hetero)arilkarboksamidi kao antagonisti androgenog receptora, njihova proizvodnja i upotreba kao medicinski produkti - Google Patents
N-[4-(hinolin-4-iloksi)cikloheksil(metil)](hetero)arilkarboksamidi kao antagonisti androgenog receptora, njihova proizvodnja i upotreba kao medicinski produktiInfo
- Publication number
- RS55500B1 RS55500B1 RS20161149A RSP20161149A RS55500B1 RS 55500 B1 RS55500 B1 RS 55500B1 RS 20161149 A RS20161149 A RS 20161149A RS P20161149 A RSP20161149 A RS P20161149A RS 55500 B1 RS55500 B1 RS 55500B1
- Authority
- RS
- Serbia
- Prior art keywords
- shape
- arylcarboxamides
- yloxy
- quinoline
- hetero
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Description
OBLAST TEHNIKE IZ KOJE JE PRONALAZAK
<p>ronalazak pripada oblasti radiologije, odnosno radiološke zaštite na zubnim rendgen aparatima koji se postavlja direktno na zračnik rendgen aparata preko osnove zračnika i za njega fiksno pričvršćen.
TEHNIČKI PROBLEM
Pronalazak rešava problem konstrukcije zračnika zubnih rendgen aparata -
i sprečava ozračivanje nepotrebnih površina lica bolesnika, u obliku je teleskopa. Prati željene nagibne uglove i zračenje se odvija sarno na format filma, a sve ostale površine ostaju zaštićene. Obzirom da se postavlja jednostavnim skidanjem plastičnog konusa ili cevi sa zračnika rendgen aparata daje visoku radiološku zaštitu bolesniku - eliminiše sekundarno zračenje prostorije.
Na zračnicima zubnih rendgen aparata postojali su plastični konusi koji su navojem koji se nalazi na dnu fiksirani na zračnik. Njihova dužina je od ^-6 cm i to je predstavljalo rastojanje fokus - koža bolesnika. Bočno zračenje 17 cm a fokusno 60 cm. Veliko sekundarno zračenje prostorije koja mora biti izolovana i zasebna.
IZLAGANJE SUŠTINE PRONALASKA
Postavljanjem mobilnog kružnog zaštitnika na zračniku oko aparata u obliku teleskopa - dobijamo rastojanje fokus - koža pacijena 21 cm a kliznom stazom regulišemo nagibni ugao regije koju želimo snimiti i to samo na površini 3 x A cm.
Bočno zračenje ćelom dužinom je eliminisamo. Pokusno smanjeno do 91%. Sekundarno zračenje prostorije eliminisamo.
Nepotrebna radiološka kecelja.
KRATAK OPIS SLIKA NACRTA
Pronalazak je detaljno opisan na primeru načina izvodjenja prikazanom na nacrtu u kome
SI. 1. predstavlja aksonometrijski prikaz zaštitnika na kome je
prestavljer. pronalazak sa spuštenom kliznom stazom
SI. 2. Predstavlja izgled pronalaska sa dignutom kliznom stazom
SI. 3. Predstavlja bočni presek.
DETALJAN OPIS PRONALASKA
Slike prikazuju mobilni orizmatični zaštitnik na zračniku zubnih rendgen aparata koji je sastavljen od tela tubusa 1 po kome se pomera klizna staza 2, sa prednjeg dela u koji je postavljen žlje'o u obliku slova "U" koji naleže na regio nosa i zatvara nagibni ugao za snimanje prednjih gornjih zuba od 3-3 postavljanjem klizne staze na osnovu a iznad oblika slova "U" latinice dobijamo poziciju za snimanje regije od 4-8 zuba gornje vilice. Telo (1) se kreće u osnovi (7) i tako postavlja za regiju gornje i donje vilice.
U skladu sa željenim ostvarenjem pronalaska klizna staza 3 koja sprečava zračenje veće površine od potrebne.
Claims (1)
- Mobilni kružni zaštitnik na zračnik zubnog rsncigen aparata za koji se traži zaštita sastoji se u tome što se na gornju osnovu (1) zaruoljenog kruga nastavlja šuplji kružni deo "NAZNAČEN TIME" što sa izrazito zako-čenim gornjim ivicama na kojima je izveden šie'o oblika slova "u" latinice a na samoj prednjoj strani (2) oko koga je postavljen klizač (3) oblika šu<p>ije<g>kruga sa dve strane pc 1 vijkom za fiksiranje (-!) dok su na dnu šupljeg kružnog dela bočno, postavljeni navoji za kružno kretanje tela oko osnove (5) ispod koje je postavljena kružna pločica sa kvadratnim osnovom u centru (6) pa sieđeća pločica samo u obliku kruga ispod koje su navoji za fiksiranje (7) tela na zračnik zubnog rendgen aparata (5) udubljen polukružni kanal za kretanje klizne staze oko tela zaštitnika.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12004764 | 2012-06-26 | ||
| EP13731325.0A EP2864291B1 (en) | 2012-06-26 | 2013-06-24 | N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products |
| PCT/EP2013/063118 WO2014001247A1 (en) | 2012-06-26 | 2013-06-24 | N-[4-(Quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS55500B1 true RS55500B1 (sr) | 2017-05-31 |
Family
ID=48699019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20161149A RS55500B1 (sr) | 2012-06-26 | 2013-06-24 | N-[4-(hinolin-4-iloksi)cikloheksil(metil)](hetero)arilkarboksamidi kao antagonisti androgenog receptora, njihova proizvodnja i upotreba kao medicinski produkti |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9428460B2 (sr) |
| EP (1) | EP2864291B1 (sr) |
| JP (1) | JP6181172B2 (sr) |
| KR (1) | KR20150023880A (sr) |
| AP (1) | AP3919A (sr) |
| AR (1) | AR091565A1 (sr) |
| AU (1) | AU2013283543B2 (sr) |
| BR (1) | BR112014032538A2 (sr) |
| CA (1) | CA2877786C (sr) |
| CL (1) | CL2014003443A1 (sr) |
| CO (1) | CO7170167A2 (sr) |
| CR (1) | CR20140593A (sr) |
| CU (1) | CU20140144A7 (sr) |
| CY (1) | CY1118412T1 (sr) |
| DK (1) | DK2864291T3 (sr) |
| DO (1) | DOP2014000295A (sr) |
| EA (1) | EA028063B1 (sr) |
| EC (1) | ECSP14032516A (sr) |
| ES (1) | ES2609455T3 (sr) |
| HR (1) | HRP20161745T1 (sr) |
| HU (1) | HUE032306T2 (sr) |
| IL (1) | IL236146B (sr) |
| JO (1) | JO3342B1 (sr) |
| LT (1) | LT2864291T (sr) |
| MA (1) | MA37700B1 (sr) |
| ME (1) | ME02590B (sr) |
| MX (1) | MX2014016054A (sr) |
| NZ (1) | NZ703100A (sr) |
| PE (1) | PE20150154A1 (sr) |
| PH (1) | PH12014502869B1 (sr) |
| PL (1) | PL2864291T3 (sr) |
| PT (1) | PT2864291T (sr) |
| RS (1) | RS55500B1 (sr) |
| SG (1) | SG11201408254UA (sr) |
| SI (1) | SI2864291T1 (sr) |
| TN (1) | TN2014000532A1 (sr) |
| TW (1) | TWI600646B (sr) |
| UA (1) | UA115447C2 (sr) |
| UY (1) | UY34881A (sr) |
| WO (1) | WO2014001247A1 (sr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160145803A (ko) * | 2014-04-22 | 2016-12-20 | 님버스 아이리스 인코포레이티드 | Irak 억제제 및 이의 용도 |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| WO2017192840A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2017192813A1 (en) * | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
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| US5328821A (en) | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| AU2001268040A1 (en) | 2000-06-23 | 2002-01-08 | Eli Lilly And Company | Methods and compounds for inhibiting mrp1 |
| AU2002313249B2 (en) | 2001-06-22 | 2008-08-21 | Kirin Pharma Kabushiki Kaisha | Quinoline derivative and quinazoline derivate inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same |
| AU2003261974A1 (en) | 2002-09-11 | 2004-04-30 | Kureha Chemical Industry Company, Limited | Amine compounds and use thereof |
| US20050227932A1 (en) | 2002-11-13 | 2005-10-13 | Tianbao Lu | Combinational therapy involving a small molecule inhibitor of the MDM2: p53 interaction |
| US20040242613A1 (en) | 2003-01-30 | 2004-12-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of PKC-theta |
| SE0302573D0 (sv) | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| EP1725238A4 (en) | 2004-03-17 | 2009-04-01 | Glaxo Group Ltd | M 3 MUSCARINACETYLCHOLINE RECEPTOR ANTAGONISTS |
| SE0401342D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
| WO2005117570A1 (en) | 2004-05-27 | 2005-12-15 | Jack Saffron | Feeding dish to prevent pest infestation |
| SG155229A1 (en) | 2004-11-09 | 2009-09-30 | Smithkline Beecham Corp | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| GB0509224D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of intracellular enzymatic activity |
| US20060293341A1 (en) | 2005-06-23 | 2006-12-28 | Vrej Jubian | Alkyl sulfonamide derivatives |
| CN101378747A (zh) | 2006-02-06 | 2009-03-04 | 昭和电工株式会社 | 增白皮肤病制剂 |
| JP2009539878A (ja) | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| WO2008064432A1 (en) | 2006-12-01 | 2008-06-05 | The University Of Sydney | Polycyclic molecular compounds |
| JP5634263B2 (ja) | 2007-08-16 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナゾリンジオンキマーゼ阻害剤 |
| EP2620432A3 (en) * | 2007-10-26 | 2013-12-18 | The Regents Of the University of California | Diarylhydantoin compounds |
| AU2009246263B2 (en) | 2008-05-14 | 2014-08-21 | Amgen Inc. | Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-Met) inhibitors for the treatment of cancer |
| JP2012504606A (ja) | 2008-10-01 | 2012-02-23 | ラディック インスティテュート フォー キャンサー リサーチ | 癌の治療方法 |
| AU2010276441B2 (en) | 2009-07-21 | 2015-07-02 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| WO2011029782A1 (en) | 2009-09-11 | 2011-03-17 | Bayer Schering Pharma Aktiengesellschaft | Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs |
| US9050334B2 (en) | 2010-07-16 | 2015-06-09 | Innov88 Llc | MIF inhibitors and their uses |
-
2013
- 2013-06-24 HU HUE13731325A patent/HUE032306T2/en unknown
- 2013-06-24 PL PL13731325T patent/PL2864291T3/pl unknown
- 2013-06-24 SG SG11201408254UA patent/SG11201408254UA/en unknown
- 2013-06-24 UA UAA201500561A patent/UA115447C2/uk unknown
- 2013-06-24 ES ES13731325.0T patent/ES2609455T3/es active Active
- 2013-06-24 LT LTEP13731325.0T patent/LT2864291T/lt unknown
- 2013-06-24 AP AP2014008141A patent/AP3919A/en active
- 2013-06-24 WO PCT/EP2013/063118 patent/WO2014001247A1/en not_active Ceased
- 2013-06-24 NZ NZ703100A patent/NZ703100A/en not_active IP Right Cessation
- 2013-06-24 CA CA2877786A patent/CA2877786C/en not_active Expired - Fee Related
- 2013-06-24 JO JOP/2013/0192A patent/JO3342B1/ar active
- 2013-06-24 PE PE2014002495A patent/PE20150154A1/es active IP Right Grant
- 2013-06-24 MX MX2014016054A patent/MX2014016054A/es unknown
- 2013-06-24 DK DK13731325.0T patent/DK2864291T3/en active
- 2013-06-24 AU AU2013283543A patent/AU2013283543B2/en not_active Ceased
- 2013-06-24 EP EP13731325.0A patent/EP2864291B1/en active Active
- 2013-06-24 ME MEP-2016-292A patent/ME02590B/me unknown
- 2013-06-24 RS RS20161149A patent/RS55500B1/sr unknown
- 2013-06-24 MA MA37700A patent/MA37700B1/fr unknown
- 2013-06-24 US US14/408,876 patent/US9428460B2/en not_active Expired - Fee Related
- 2013-06-24 SI SI201330440A patent/SI2864291T1/sl unknown
- 2013-06-24 HR HRP20161745TT patent/HRP20161745T1/hr unknown
- 2013-06-24 KR KR20157001996A patent/KR20150023880A/ko not_active Ceased
- 2013-06-24 BR BR112014032538A patent/BR112014032538A2/pt not_active Application Discontinuation
- 2013-06-24 PT PT137313250T patent/PT2864291T/pt unknown
- 2013-06-24 EA EA201500039A patent/EA028063B1/ru not_active IP Right Cessation
- 2013-06-24 JP JP2015519023A patent/JP6181172B2/ja not_active Expired - Fee Related
- 2013-06-26 TW TW102122775A patent/TWI600646B/zh not_active IP Right Cessation
- 2013-06-26 UY UY0001034881A patent/UY34881A/es not_active Application Discontinuation
- 2013-06-26 AR ARP130102253 patent/AR091565A1/es unknown
-
2014
- 2014-12-09 IL IL236146A patent/IL236146B/en active IP Right Grant
- 2014-12-18 CU CUP2014000144A patent/CU20140144A7/es unknown
- 2014-12-18 CR CR20140593A patent/CR20140593A/es unknown
- 2014-12-18 CL CL2014003443A patent/CL2014003443A1/es unknown
- 2014-12-19 DO DO2014000295A patent/DOP2014000295A/es unknown
- 2014-12-19 CO CO14279115A patent/CO7170167A2/es unknown
- 2014-12-19 EC ECIEPI201432516A patent/ECSP14032516A/es unknown
- 2014-12-22 PH PH12014502869A patent/PH12014502869B1/en unknown
- 2014-12-25 TN TN2014000532A patent/TN2014000532A1/fr unknown
-
2016
- 2016-12-23 CY CY20161101343T patent/CY1118412T1/el unknown
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