CR20150003A - Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huérfano rory - Google Patents

Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huérfano rory

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Publication number
CR20150003A
CR20150003A CR20150003A CR20150003A CR20150003A CR 20150003 A CR20150003 A CR 20150003A CR 20150003 A CR20150003 A CR 20150003A CR 20150003 A CR20150003 A CR 20150003A CR 20150003 A CR20150003 A CR 20150003A
Authority
CR
Costa Rica
Prior art keywords
modulators
nuclear receptor
tiazols
rory
sulfonamide
Prior art date
Application number
CR20150003A
Other languages
English (en)
Inventor
Christian Gege
Christoph Steeneck
Olaf Kinzel
Gerald Kleymann
Thomas Hoffmann
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49672489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150003(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Publication of CR20150003A publication Critical patent/CR20150003A/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La invención provee moduladores para el receptor nuclear huérfano ROR y métodos para tratar enfermedades mediadas por ROR mediante la administración de estos moduladores novedosos de ROR a un humano o mamífero que los necesite
CR20150003A 2012-05-31 2015-01-05 Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huérfano rory CR20150003A (es)

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US201261653556P 2012-05-31 2012-05-31
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PCT/EP2013/001593 WO2013178362A1 (en) 2012-05-31 2013-05-29 Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]

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