CR20160098A - Polimorfo de los inhibidores de la syk - Google Patents

Polimorfo de los inhibidores de la syk

Info

Publication number
CR20160098A
CR20160098A CR20160098A CR20160098A CR20160098A CR 20160098 A CR20160098 A CR 20160098A CR 20160098 A CR20160098 A CR 20160098A CR 20160098 A CR20160098 A CR 20160098A CR 20160098 A CR20160098 A CR 20160098A
Authority
CR
Costa Rica
Prior art keywords
polymorph
syk inhibitors
bimesylate
polymorphs
salt
Prior art date
Application number
CR20160098A
Other languages
English (en)
Inventor
Peter Chee-Chu Fung
Dimitrios Stefanidis
Dragos Vizitiu
Tim G Elford
Michael Laird Hurrey
Original Assignee
Gilead Connecticut Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51301367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20160098(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Connecticut Inc filed Critical Gilead Connecticut Inc
Publication of CR20160098A publication Critical patent/CR20160098A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

Se proporcionan los polimorfos de la sal bimesilato de un compuesto de la Fórmula I, o un hidrato de la misma. También sepuede representar la sal bimesilato como un compuesto de laFórmula IA. En este documento también se proporcionan lascomposiciones de los mismos, los métodos para su preparacióny los métodos para la obtención de dichos polimorfos.
CR20160098A 2013-07-30 2016-02-29 Polimorfo de los inhibidores de la syk CR20160098A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361860197P 2013-07-30 2013-07-30
PCT/US2014/048733 WO2015017460A1 (en) 2013-07-30 2014-07-29 Polymorph of syk inhibitors

Publications (1)

Publication Number Publication Date
CR20160098A true CR20160098A (es) 2016-07-11

Family

ID=51301367

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160098A CR20160098A (es) 2013-07-30 2016-02-29 Polimorfo de los inhibidores de la syk

Country Status (33)

Country Link
US (4) US20160168155A1 (es)
EP (1) EP3027618B1 (es)
JP (1) JP6230709B2 (es)
KR (1) KR101810798B1 (es)
CN (1) CN105452252A (es)
AP (1) AP2016009008A0 (es)
AR (1) AR097158A1 (es)
AU (2) AU2014296308C1 (es)
CA (1) CA2919661C (es)
CL (1) CL2016000238A1 (es)
CR (1) CR20160098A (es)
DK (1) DK3027618T3 (es)
EA (2) EA201791873A1 (es)
ES (1) ES2822285T3 (es)
HK (1) HK1222390A1 (es)
HR (1) HRP20201582T1 (es)
HU (1) HUE052090T2 (es)
IL (1) IL243579A0 (es)
MD (1) MD4659B1 (es)
MX (1) MX2016001304A (es)
MY (1) MY176803A (es)
NZ (1) NZ715776A (es)
PE (1) PE20160862A1 (es)
PH (1) PH12016500169A1 (es)
PL (1) PL3027618T3 (es)
PT (1) PT3027618T (es)
PY (1) PY1432622A (es)
SG (1) SG11201600385TA (es)
SI (1) SI3027618T1 (es)
SV (1) SV2016005149A (es)
TW (1) TW201602108A (es)
UY (1) UY35683A (es)
WO (1) WO2015017460A1 (es)

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US11339168B2 (en) 2019-02-22 2022-05-24 Kronos Bio, Inc. Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
CN113402506B (zh) * 2021-06-17 2023-06-16 四川大学 中间体和制备方法及其在合成长春布宁上的应用

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