CR20230130A - Proceso e intermedios para preparar un inhibidor de jak1 - Google Patents

Proceso e intermedios para preparar un inhibidor de jak1

Info

Publication number
CR20230130A
CR20230130A CR20230130A CR20230130A CR20230130A CR 20230130 A CR20230130 A CR 20230130A CR 20230130 A CR20230130 A CR 20230130A CR 20230130 A CR20230130 A CR 20230130A CR 20230130 A CR20230130 A CR 20230130A
Authority
CR
Costa Rica
Prior art keywords
preparing
intermediates
jak1 inhibitor
jak1
inhibitor
Prior art date
Application number
CR20230130A
Other languages
English (en)
Inventor
Michael Xia
Pingli Liu
Shili Chen
David J Meloni
Naijing Su
Jiacheng Zhou
Yongchun Pan
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20230130A publication Critical patent/CR20230130A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)

Abstract

La presente invención se refiere a procesos para preparar itacitinib, o una sal de este, e intermedios sintéticos relacionados que se relacionan con estos.
CR20230130A 2020-08-18 2021-08-17 Proceso e intermedios para preparar un inhibidor de jak1 CR20230130A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063067062P 2020-08-18 2020-08-18
PCT/US2021/046286 WO2022040172A1 (en) 2020-08-18 2021-08-17 Process and intermediates for preparing a jak1 inhibitor

Publications (1)

Publication Number Publication Date
CR20230130A true CR20230130A (es) 2023-07-13

Family

ID=77693614

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20230130A CR20230130A (es) 2020-08-18 2021-08-17 Proceso e intermedios para preparar un inhibidor de jak1

Country Status (18)

Country Link
US (2) US11897889B2 (es)
EP (1) EP4200278A1 (es)
JP (1) JP7778135B2 (es)
KR (1) KR20230095923A (es)
CN (1) CN117043152A (es)
AR (1) AR123268A1 (es)
AU (1) AU2021329301A1 (es)
BR (1) BR112023002939A2 (es)
CA (1) CA3192055A1 (es)
CL (2) CL2023000482A1 (es)
CO (1) CO2023003286A2 (es)
CR (1) CR20230130A (es)
EC (1) ECSP23019419A (es)
IL (1) IL300557A (es)
MX (1) MX2023002035A (es)
PE (1) PE20231308A1 (es)
TW (1) TWI904215B (es)
WO (1) WO2022040172A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
CA3192099A1 (en) 2020-08-18 2022-02-24 Incyte Corporation Process and intermediates for preparing a jak inhibitor
CR20230130A (es) 2020-08-18 2023-07-13 Incyte Corp Proceso e intermedios para preparar un inhibidor de jak1
CN118317946A (zh) 2021-07-12 2024-07-09 因赛特公司 用于制备巴瑞替尼的方法和中间体
CN117903032A (zh) * 2022-10-12 2024-04-19 重庆博腾制药科技股份有限公司 一种巴瑞替尼中间体的制备方法及制备巴瑞替尼的方法
CN120882718A (zh) * 2023-03-17 2025-10-31 北京普祺医药科技股份有限公司 吡咯并嘧啶化合物或其可药用盐的制备方法
CN117603193A (zh) * 2023-12-20 2024-02-27 杭州澳赛诺生物科技有限公司 一种β-氰基吡唑类化合物的合成方法
CN121135621A (zh) * 2024-06-07 2025-12-16 上海长森药业有限公司 一种jak抑制剂的制备方法及其中间体

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Also Published As

Publication number Publication date
JP2023538614A (ja) 2023-09-08
WO2022040172A1 (en) 2022-02-24
EP4200278A1 (en) 2023-06-28
JP7778135B2 (ja) 2025-12-01
IL300557A (en) 2023-04-01
AR123268A1 (es) 2022-11-16
CN117043152A (zh) 2023-11-10
US11897889B2 (en) 2024-02-13
US20220056034A1 (en) 2022-02-24
AU2021329301A1 (en) 2023-04-13
CA3192055A1 (en) 2022-02-24
PE20231308A1 (es) 2023-08-24
MX2023002035A (es) 2023-06-12
CO2023003286A2 (es) 2023-06-09
CL2024003156A1 (es) 2025-02-28
KR20230095923A (ko) 2023-06-29
TWI904215B (zh) 2025-11-11
TW202212341A (zh) 2022-04-01
ECSP23019419A (es) 2023-04-28
US20240246982A1 (en) 2024-07-25
CL2023000482A1 (es) 2023-09-29
US12428426B2 (en) 2025-09-30
BR112023002939A2 (pt) 2023-04-25

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