ECSP23019419A - Proceso e intermedios para preparar un inhibidor de jak1 - Google Patents

Proceso e intermedios para preparar un inhibidor de jak1

Info

Publication number
ECSP23019419A
ECSP23019419A ECSENADI202319419A ECDI202319419A ECSP23019419A EC SP23019419 A ECSP23019419 A EC SP23019419A EC SENADI202319419 A ECSENADI202319419 A EC SENADI202319419A EC DI202319419 A ECDI202319419 A EC DI202319419A EC SP23019419 A ECSP23019419 A EC SP23019419A
Authority
EC
Ecuador
Prior art keywords
intermediates
prepare
jak1 inhibitor
jak1
inhibitor
Prior art date
Application number
ECSENADI202319419A
Other languages
English (en)
Inventor
Yongchun Pan
Shili Chen
David J Meloni
Pingli Liu
Michael Xia
Jiacheng Zhou
Naijing Su
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP23019419A publication Critical patent/ECSP23019419A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)

Abstract

La presente invención se refiere a procesos para preparar itacitinib, o una sal de este, e intermedios sintéticos relacionados que se relacionan con estos.
ECSENADI202319419A 2020-08-18 2023-03-16 Proceso e intermedios para preparar un inhibidor de jak1 ECSP23019419A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063067062P 2020-08-18 2020-08-18

Publications (1)

Publication Number Publication Date
ECSP23019419A true ECSP23019419A (es) 2023-04-28

Family

ID=77693614

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202319419A ECSP23019419A (es) 2020-08-18 2023-03-16 Proceso e intermedios para preparar un inhibidor de jak1

Country Status (18)

Country Link
US (2) US11897889B2 (es)
EP (1) EP4200278A1 (es)
JP (1) JP7778135B2 (es)
KR (1) KR20230095923A (es)
CN (1) CN117043152A (es)
AR (1) AR123268A1 (es)
AU (1) AU2021329301A1 (es)
BR (1) BR112023002939A2 (es)
CA (1) CA3192055A1 (es)
CL (2) CL2023000482A1 (es)
CO (1) CO2023003286A2 (es)
CR (1) CR20230130A (es)
EC (1) ECSP23019419A (es)
IL (1) IL300557A (es)
MX (1) MX2023002035A (es)
PE (1) PE20231308A1 (es)
TW (1) TWI904215B (es)
WO (1) WO2022040172A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
IL300555A (en) 2020-08-18 2023-04-01 Incyte Corp Process and intermediates for preparing a JAK inhibitor
CA3192055A1 (en) 2020-08-18 2022-02-24 Incyte Corporation Process and intermediates for preparing a jak1 inhibitor
CA3226714A1 (en) 2021-07-12 2023-01-19 Incyte Corporation Process and intermediates for preparing baricitinib
CN117903032A (zh) * 2022-10-12 2024-04-19 重庆博腾制药科技股份有限公司 一种巴瑞替尼中间体的制备方法及制备巴瑞替尼的方法
CN120882718A (zh) * 2023-03-17 2025-10-31 北京普祺医药科技股份有限公司 吡咯并嘧啶化合物或其可药用盐的制备方法
CN121135621A (zh) * 2024-06-07 2025-12-16 上海长森药业有限公司 一种jak抑制剂的制备方法及其中间体

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Also Published As

Publication number Publication date
PE20231308A1 (es) 2023-08-24
US11897889B2 (en) 2024-02-13
IL300557A (en) 2023-04-01
BR112023002939A2 (pt) 2023-04-25
CO2023003286A2 (es) 2023-06-09
CL2023000482A1 (es) 2023-09-29
TWI904215B (zh) 2025-11-11
JP2023538614A (ja) 2023-09-08
AU2021329301A1 (en) 2023-04-13
TW202212341A (zh) 2022-04-01
WO2022040172A1 (en) 2022-02-24
CN117043152A (zh) 2023-11-10
EP4200278A1 (en) 2023-06-28
US12428426B2 (en) 2025-09-30
AR123268A1 (es) 2022-11-16
US20240246982A1 (en) 2024-07-25
CR20230130A (es) 2023-07-13
CA3192055A1 (en) 2022-02-24
US20220056034A1 (en) 2022-02-24
MX2023002035A (es) 2023-06-12
CL2024003156A1 (es) 2025-02-28
KR20230095923A (ko) 2023-06-29
JP7778135B2 (ja) 2025-12-01

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