CR20230211A - Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetas - Google Patents
Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetasInfo
- Publication number
- CR20230211A CR20230211A CR20230211A CR20230211A CR20230211A CR 20230211 A CR20230211 A CR 20230211A CR 20230211 A CR20230211 A CR 20230211A CR 20230211 A CR20230211 A CR 20230211A CR 20230211 A CR20230211 A CR 20230211A
- Authority
- CR
- Costa Rica
- Prior art keywords
- sup
- cyclopentathiophen
- antagonists
- factor receptor
- platelet activation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Ciclopentatiofen carboxamidas de la Fórmula (I.0)en donde R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup>, R<sup>4</sup> y n son como se definen en la descripción y las reivindicaciones, y las sales de este aceptables desde el punto de vista farmacéutico pueden usarse en métodos para el tratamiento de enfermedades que pueden estar influenciadas por antagonizar la actividad mediada por el receptor del factor de activación de plaquetas. <img alt="" src="data:image/png;base64,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 (***)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20207719 | 2020-11-16 | ||
| PCT/EP2021/081459 WO2022101377A1 (en) | 2020-11-16 | 2021-11-12 | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20230211A true CR20230211A (es) | 2023-07-13 |
Family
ID=73543025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20230211A CR20230211A (es) | 2020-11-16 | 2021-11-12 | Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetas |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11766443B2 (es) |
| EP (1) | EP4244229A1 (es) |
| JP (2) | JP7465368B2 (es) |
| KR (1) | KR20230109692A (es) |
| CN (2) | CN116745300A (es) |
| AR (1) | AR124070A1 (es) |
| AU (1) | AU2021379248A1 (es) |
| CA (1) | CA3200710A1 (es) |
| CL (2) | CL2023001361A1 (es) |
| CO (1) | CO2023005894A2 (es) |
| CR (1) | CR20230211A (es) |
| DO (1) | DOP2023000090A (es) |
| EC (1) | ECSP23036210A (es) |
| IL (1) | IL302769A (es) |
| JO (1) | JOP20230107A1 (es) |
| MX (1) | MX2023005678A (es) |
| PE (1) | PE20231855A1 (es) |
| SA (1) | SA523440809B1 (es) |
| TW (1) | TWI913356B (es) |
| WO (1) | WO2022101377A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119842821A (zh) * | 2025-01-06 | 2025-04-18 | 华中科技大学 | 稳定表达血小板活化因子受体的细胞株、构建方法及应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3502392A1 (de) | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
| JPS62181282A (ja) * | 1986-01-21 | 1987-08-08 | ベ−リンガ− インゲルハイム コマンデイツト ゲゼルシヤフト | チエノ−１，４−ジアゼピン |
| PH30676A (en) | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
| US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
| MC1999A1 (fr) * | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| EP0368175A1 (de) | 1988-11-06 | 1990-05-16 | Boehringer Ingelheim Kg | 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin. |
| DE3909012A1 (de) | 1989-03-18 | 1990-09-20 | Boehringer Ingelheim Kg | Verbessertes verfahren zur herstellung von enantiomerenreinen hetrazepinen |
| DE4010528A1 (de) | 1990-04-02 | 1991-10-17 | Boehringer Ingelheim Kg | Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine |
| JP2959598B2 (ja) | 1990-10-12 | 1999-10-06 | 吉富製薬株式会社 | 光学活性なチエノトリアゾロジアゼピン化合物 |
| CN1033327C (zh) | 1991-04-23 | 1996-11-20 | 东丽株式会社 | 三环三唑并衍生物的制造方法 |
| DE4132763A1 (de) | 1991-10-02 | 1993-04-08 | Boehringer Ingelheim Kg | Verbessertes verfahren zur herstellung von enantiomerenreinen saeureamiden hetrazepinoider struktur |
| FR2779652B1 (fr) | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
| US20050032713A1 (en) * | 2002-03-27 | 2005-02-10 | Wurtman Richard J. | Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents |
| US7749996B2 (en) | 2006-11-20 | 2010-07-06 | Alantos Pharmaceutical Holdings, Inc. | Heterotricyclic metalloprotease inhibitors |
-
2021
- 2021-11-12 CR CR20230211A patent/CR20230211A/es unknown
- 2021-11-12 KR KR1020237020295A patent/KR20230109692A/ko active Pending
- 2021-11-12 JP JP2022562298A patent/JP7465368B2/ja active Active
- 2021-11-12 IL IL302769A patent/IL302769A/en unknown
- 2021-11-12 CA CA3200710A patent/CA3200710A1/en active Pending
- 2021-11-12 MX MX2023005678A patent/MX2023005678A/es unknown
- 2021-11-12 CN CN202180076849.5A patent/CN116745300A/zh active Pending
- 2021-11-12 PE PE2023001605A patent/PE20231855A1/es unknown
- 2021-11-12 WO PCT/EP2021/081459 patent/WO2022101377A1/en not_active Ceased
- 2021-11-12 AU AU2021379248A patent/AU2021379248A1/en active Pending
- 2021-11-12 EP EP21806745.2A patent/EP4244229A1/en active Pending
- 2021-11-12 US US17/524,759 patent/US11766443B2/en active Active
- 2021-11-12 CN CN202311341729.0A patent/CN117624188A/zh active Pending
- 2021-11-15 AR ARP210103159A patent/AR124070A1/es unknown
- 2021-11-15 TW TW110142333A patent/TWI913356B/zh active
-
2023
- 2023-05-08 CO CONC2023/0005894A patent/CO2023005894A2/es unknown
- 2023-05-11 CL CL2023001361A patent/CL2023001361A1/es unknown
- 2023-05-11 DO DO2023000090A patent/DOP2023000090A/es unknown
- 2023-05-16 JO JOJO/P/2023/0107A patent/JOP20230107A1/ar unknown
- 2023-05-16 SA SA523440809A patent/SA523440809B1/ar unknown
- 2023-05-17 EC ECSENADI202336210A patent/ECSP23036210A/es unknown
- 2023-07-14 US US18/221,936 patent/US20230355638A1/en active Pending
-
2024
- 2024-02-01 CL CL2024000317A patent/CL2024000317A1/es unknown
- 2024-03-29 JP JP2024055696A patent/JP7810743B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021379248A9 (en) | 2024-10-10 |
| IL302769A (en) | 2023-07-01 |
| TWI913356B (zh) | 2026-02-01 |
| EP4244229A1 (en) | 2023-09-20 |
| JP7810743B2 (ja) | 2026-02-03 |
| AR124070A1 (es) | 2023-02-08 |
| SA523440809B1 (ar) | 2024-10-08 |
| ECSP23036210A (es) | 2023-06-30 |
| WO2022101377A1 (en) | 2022-05-19 |
| TW202237620A (zh) | 2022-10-01 |
| JP7465368B2 (ja) | 2024-04-10 |
| CL2023001361A1 (es) | 2023-11-03 |
| CL2024000317A1 (es) | 2024-07-12 |
| CA3200710A1 (en) | 2022-05-19 |
| US20230355638A1 (en) | 2023-11-09 |
| MX2023005678A (es) | 2023-05-26 |
| DOP2023000090A (es) | 2023-06-15 |
| KR20230109692A (ko) | 2023-07-20 |
| US20220160725A1 (en) | 2022-05-26 |
| JP2023521200A (ja) | 2023-05-23 |
| JOP20230107A1 (ar) | 2023-05-16 |
| CO2023005894A2 (es) | 2023-05-29 |
| JP2024099528A (ja) | 2024-07-25 |
| PE20231855A1 (es) | 2023-11-21 |
| AU2021379248A1 (en) | 2023-06-22 |
| US11766443B2 (en) | 2023-09-26 |
| CN116745300A (zh) | 2023-09-12 |
| CN117624188A (zh) | 2024-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Feil Weber et al. | CARE TRANSITION FROM HOSPITAL TO HOME: INTEGRATIVE REVIEW. | |
| Corcoran et al. | NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memory | |
| AR085219A1 (es) | 6-cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del snc | |
| AR113890A1 (es) | Preparado farmacéutico con excelentes propiedades de estabilidad a la luz y disolución | |
| CL2019002601A1 (es) | Derivados pirazol[1,5-a]pirimidina sustituidos con alicíclicos farmacológicamente activos. | |
| CL2023001361A1 (es) | Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetas | |
| Elovic et al. | The use of atypical antipsychotics after traumatic brain injury | |
| Grau et al. | Is There Still a Role for Intravenous Heparin in Acute Stroke?: Yes | |
| Fukunaga et al. | The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading | |
| Meyer et al. | A note on Thomas Willis' views on the corpus striatum and the internal capsule | |
| Rajkumar | Supersensitivity psychosis and its response to asenapine in a patient with delusional disorder | |
| Cammarata-Scalisi et al. | Hallazgos clínicos y genéticos de dos casos con síndrome de Apert | |
| Sridhar et al. | Retinal diseases: Current medical and surgical updates and a look to the future | |
| Friedman | Analogies | |
| Avila et al. | Cardio-obstetrics: a critical, growing subspecialty | |
| Efird | UAB Faculty Development Grant Program awards nearly $100,000 to School of Medicine faculty | |
| CN108784966A (zh) | 可移动方便取物和康复两用装置 | |
| Gill et al. | Ensuring universal access to insulin--the International Insulin Foundation position statement. | |
| Rosenbaum et al. | Serotonin syndrome with propofol and remifentanil: mechanistic concern and alternative diagnosis | |
| Salem et al. | Duplication of the radial artery | |
| Nafrialdi | Twenty two years of the Medical Journal of Indonesia | |
| Patiño-Toscano | Pain management in open nephrectomy | |
| Arbore | Control of IFN-γ response via autocrine activation of the C5a complement receptors and the NLRP3 inflammasome within human T lymphocytes | |
| Tatar et al. | Clozapine--Induced Neuroleptic Malignant Syndrome Associated with Rapid Dose Escalation. | |
| Markova et al. | Response to “CYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers” |