CR20250043A - Derivados bicíclicos de tetrahidrotiazepina - Google Patents

Derivados bicíclicos de tetrahidrotiazepina

Info

Publication number
CR20250043A
CR20250043A CR20250043A CR20250043A CR20250043A CR 20250043 A CR20250043 A CR 20250043A CR 20250043 A CR20250043 A CR 20250043A CR 20250043 A CR20250043 A CR 20250043A CR 20250043 A CR20250043 A CR 20250043A
Authority
CR
Costa Rica
Prior art keywords
tetrahydrothiazepine
derivatives
bicyclic
zvshn
yyfnwohz
Prior art date
Application number
CR20250043A
Other languages
English (en)
Inventor
Laetitia Janine Martin
Nenad Manevski
Roman Hutter
Barbara Johanna Mueller
Marco Brandstaetter
Holger Kuehne
Thomas Luebbers
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20250043A publication Critical patent/CR20250043A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona nuevos derivados bicíclicos de tetrahidrotiazepina que tienen la fórmula general (I) <img alt="" src="data:image/png;base64,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 (***)
CR20250043A 2022-08-11 2023-08-09 Derivados bicíclicos de tetrahidrotiazepina CR20250043A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22189820 2022-08-11
PCT/EP2023/071990 WO2024033389A1 (en) 2022-08-11 2023-08-09 Bicyclic tetrahydrothiazepine derivatives

Publications (1)

Publication Number Publication Date
CR20250043A true CR20250043A (es) 2025-03-25

Family

ID=82899256

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20250043A CR20250043A (es) 2022-08-11 2023-08-09 Derivados bicíclicos de tetrahidrotiazepina

Country Status (16)

Country Link
EP (1) EP4568959A1 (es)
JP (1) JP2025526681A (es)
KR (1) KR20250048020A (es)
CN (1) CN119677733A (es)
AR (1) AR130168A1 (es)
AU (1) AU2023322638A1 (es)
CA (1) CA3262845A1 (es)
CL (1) CL2025000381A1 (es)
CO (1) CO2025003011A2 (es)
CR (1) CR20250043A (es)
IL (1) IL316935A (es)
MA (1) MA71728A (es)
MX (1) MX2025000919A (es)
PE (1) PE20250876A1 (es)
TW (1) TW202417002A (es)
WO (1) WO2024033389A1 (es)

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Also Published As

Publication number Publication date
KR20250048020A (ko) 2025-04-07
EP4568959A1 (en) 2025-06-18
CO2025003011A2 (es) 2025-03-27
PE20250876A1 (es) 2025-03-28
JP2025526681A (ja) 2025-08-15
WO2024033389A1 (en) 2024-02-15
AU2023322638A1 (en) 2024-11-28
TW202417002A (zh) 2024-05-01
MA71728A (fr) 2025-05-30
MX2025000919A (es) 2025-03-07
AR130168A1 (es) 2024-11-13
CA3262845A1 (en) 2024-02-15
IL316935A (en) 2025-01-01
CL2025000381A1 (es) 2025-04-21
CN119677733A (zh) 2025-03-21

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