MA38948B1 - Dérivés de 2h-indazole antibactériens - Google Patents
Dérivés de 2h-indazole antibactériensInfo
- Publication number
- MA38948B1 MA38948B1 MA38948A MA38948A MA38948B1 MA 38948 B1 MA38948 B1 MA 38948B1 MA 38948 A MA38948 A MA 38948A MA 38948 A MA38948 A MA 38948A MA 38948 B1 MA38948 B1 MA 38948B1
- Authority
- MA
- Morocco
- Prior art keywords
- antibacterial
- indazole derivatives
- halogen
- indazole
- derivatives
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epidemiology (AREA)
Abstract
La présente invention concerne des composés antibactériens de formule (i) dans laquelle r1 est h ou halogène; r2 est alkynyloxy ou le groupe m; r3 est h ou halogène; m est un parmi les groupes (a, b, c, d) dans lequel a est une liaison, ch2 ch2, ch=ch ou c=c et r1a, r2a, r3a, r1b et r1c sont tels que définis dans la revendication 1; et des sels de ceux-ci.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013058537 | 2013-09-13 | ||
| PCT/IB2014/064458 WO2015036964A1 (fr) | 2013-09-13 | 2014-09-12 | Dérivés de 2h-indazole antibactériens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38948A1 MA38948A1 (fr) | 2017-05-31 |
| MA38948B1 true MA38948B1 (fr) | 2018-04-30 |
Family
ID=51688371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38948A MA38948B1 (fr) | 2013-09-13 | 2014-09-12 | Dérivés de 2h-indazole antibactériens |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9802901B2 (fr) |
| EP (1) | EP3044211B1 (fr) |
| JP (1) | JP6353909B2 (fr) |
| KR (1) | KR20160055889A (fr) |
| CN (1) | CN105531264B (fr) |
| AR (1) | AR097617A1 (fr) |
| AU (1) | AU2014319966B2 (fr) |
| BR (1) | BR112016007757A8 (fr) |
| CA (1) | CA2923146A1 (fr) |
| CL (1) | CL2016000568A1 (fr) |
| CY (1) | CY1120111T1 (fr) |
| DK (1) | DK3044211T3 (fr) |
| EA (1) | EA031562B1 (fr) |
| ES (1) | ES2662894T3 (fr) |
| HR (1) | HRP20180484T1 (fr) |
| HU (1) | HUE038519T2 (fr) |
| IL (1) | IL244500B (fr) |
| LT (1) | LT3044211T (fr) |
| MA (1) | MA38948B1 (fr) |
| MX (1) | MX361733B (fr) |
| MY (1) | MY179283A (fr) |
| PH (1) | PH12016500480A1 (fr) |
| PL (1) | PL3044211T3 (fr) |
| PT (1) | PT3044211T (fr) |
| SG (1) | SG11201601889YA (fr) |
| SI (1) | SI3044211T1 (fr) |
| TW (1) | TWI646084B (fr) |
| UA (1) | UA116484C2 (fr) |
| WO (1) | WO2015036964A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160098503A (ko) | 2013-12-19 | 2016-08-18 | 액테리온 파마슈티칼 리미티드 | 항균성 1h-인다졸 및 1h-인돌 유도체 |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| WO2015173329A1 (fr) | 2014-05-16 | 2015-11-19 | Actelion Pharmaceuticals Ltd | Dérivés antibactériens de quinazoline-4(3h)-one |
| BR112017010474A2 (pt) | 2014-11-19 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados antibacterianos de benzotiazol |
| AR105646A1 (es) * | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105839A1 (es) * | 2015-08-28 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos pirrolidin-2-ona anulares |
| AR105848A1 (es) * | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| AU2017267194A1 (en) * | 2016-05-17 | 2019-01-17 | Idorsia Pharmaceuticals Ltd | 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives |
| WO2019038362A1 (fr) | 2017-08-24 | 2019-02-28 | Idorsia Pharmaceuticals Ltd | Pyrroloimidazolones antibactériennes |
| CN113372276B (zh) * | 2021-05-25 | 2022-04-22 | 三峡大学 | 吲唑类衍生物及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2469304A1 (fr) | 2001-12-05 | 2003-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | Agents anti-bacteriens de 6-o-acyl cetolide |
| US6806279B2 (en) | 2001-12-17 | 2004-10-19 | Sunesis Pharmaceuticals, Inc. | Small-molecule inhibitors of interleukin-2 |
| SG2013013339A (en) | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| EP1828145A4 (fr) | 2004-12-10 | 2009-08-19 | Univ Emory | Analogues de nucleosides de cyclobutyle a substitution 2' et 3' pour le traitement des infections virales et de la proliferation cellulaire anormale |
| PT1863818E (pt) | 2005-03-23 | 2010-04-09 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2 |
| CA2691987C (fr) | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Agents antibacteriens |
| DE102008044132A1 (de) | 2008-11-27 | 2010-06-02 | BSH Bosch und Siemens Hausgeräte GmbH | Kältegerät mit zweiseitig anschlagbarer Tür |
| WO2010100475A1 (fr) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Dérivés de l'acide hydroxamique en tant qu'agents contre des bactéries à gram négatif |
| WO2010135536A2 (fr) | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Procédés pour moduler des taux d'acide urique |
| CN102548975A (zh) | 2009-07-07 | 2012-07-04 | 安瑟生物科技私人有限公司 | 组蛋白去乙酰化酶抑制剂 |
| CA2774250C (fr) * | 2009-10-13 | 2013-12-17 | Pfizer Inc. | Derives d'acide hydroxamique a liaison c utiles comme agents antibacteriens |
| JP5793766B2 (ja) | 2009-12-16 | 2015-10-14 | ファイザー・インク | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| EP2638006A1 (fr) | 2010-11-10 | 2013-09-18 | Achaogen, Inc. | Dérivés d'acide hydroxamique et leur utilisation dans le traitement d'infections bactériennes |
| KR20120079015A (ko) | 2011-01-03 | 2012-07-11 | 한미약품 주식회사 | Ｇ 단백질-커플링된 수용체의 조절을 위한 신규한 비사이클릭 화합물 |
| AP3336A (en) * | 2011-03-07 | 2015-07-31 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| WO2012137094A1 (fr) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Dérivés d'isoxazole utiles en tant qu'agents antibactériens |
| WO2012137099A1 (fr) * | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Dérivés d'imidazole, de pyrazole et de triazole, utiles en tant qu'agents antibactériens |
| EP2847162A1 (fr) | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Agents antibactériens |
| KR20160098503A (ko) | 2013-12-19 | 2016-08-18 | 액테리온 파마슈티칼 리미티드 | 항균성 1h-인다졸 및 1h-인돌 유도체 |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| WO2015173329A1 (fr) | 2014-05-16 | 2015-11-19 | Actelion Pharmaceuticals Ltd | Dérivés antibactériens de quinazoline-4(3h)-one |
-
2014
- 2014-09-10 AR ARP140103376A patent/AR097617A1/es unknown
- 2014-09-12 SG SG11201601889YA patent/SG11201601889YA/en unknown
- 2014-09-12 AU AU2014319966A patent/AU2014319966B2/en not_active Ceased
- 2014-09-12 DK DK14781948.6T patent/DK3044211T3/en active
- 2014-09-12 EP EP14781948.6A patent/EP3044211B1/fr not_active Not-in-force
- 2014-09-12 BR BR112016007757A patent/BR112016007757A8/pt not_active Application Discontinuation
- 2014-09-12 TW TW103131666A patent/TWI646084B/zh not_active IP Right Cessation
- 2014-09-12 KR KR1020167009718A patent/KR20160055889A/ko not_active Ceased
- 2014-09-12 ES ES14781948.6T patent/ES2662894T3/es active Active
- 2014-09-12 PL PL14781948T patent/PL3044211T3/pl unknown
- 2014-09-12 WO PCT/IB2014/064458 patent/WO2015036964A1/fr not_active Ceased
- 2014-09-12 JP JP2016542426A patent/JP6353909B2/ja not_active Expired - Fee Related
- 2014-09-12 CN CN201480049877.8A patent/CN105531264B/zh not_active Expired - Fee Related
- 2014-09-12 HU HUE14781948A patent/HUE038519T2/hu unknown
- 2014-09-12 MX MX2016003196A patent/MX361733B/es active IP Right Grant
- 2014-09-12 MY MYPI2016700850A patent/MY179283A/en unknown
- 2014-09-12 HR HRP20180484TT patent/HRP20180484T1/hr unknown
- 2014-09-12 MA MA38948A patent/MA38948B1/fr unknown
- 2014-09-12 SI SI201430662T patent/SI3044211T1/en unknown
- 2014-09-12 EA EA201600248A patent/EA031562B1/ru not_active IP Right Cessation
- 2014-09-12 US US15/021,649 patent/US9802901B2/en not_active Expired - Fee Related
- 2014-09-12 LT LTEP14781948.6T patent/LT3044211T/lt unknown
- 2014-09-12 CA CA2923146A patent/CA2923146A1/fr not_active Abandoned
- 2014-09-12 PT PT147819486T patent/PT3044211T/pt unknown
- 2014-12-09 UA UAA201603879A patent/UA116484C2/uk unknown
-
2016
- 2016-03-08 IL IL244500A patent/IL244500B/en not_active IP Right Cessation
- 2016-03-10 CL CL2016000568A patent/CL2016000568A1/es unknown
- 2016-03-11 PH PH12016500480A patent/PH12016500480A1/en unknown
-
2018
- 2018-03-30 CY CY20181100362T patent/CY1120111T1/el unknown
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