CR20260043A - Anticuerpos anti-proteína a-beta, métodos y usos de estos - Google Patents

Anticuerpos anti-proteína a-beta, métodos y usos de estos

Info

Publication number
CR20260043A
CR20260043A CR20260043A CR20260043A CR20260043A CR 20260043 A CR20260043 A CR 20260043A CR 20260043 A CR20260043 A CR 20260043A CR 20260043 A CR20260043 A CR 20260043A CR 20260043 A CR20260043 A CR 20260043A
Authority
CR
Costa Rica
Prior art keywords
cdrs
beta protein
methods
seq
protein antibodies
Prior art date
Application number
CR20260043A
Other languages
English (en)
Inventor
Jens Niewoehner
Per-Ola Freskgard
Markus Neubauer
Sabine Imhof-Jung
Petra Rueger
Guy Georges
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20260043A publication Critical patent/CR20260043A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se informa un anticuerpo que se une a la proteína A-beta humana, en donde el anticuerpo comprende un dominio variable de la cadena pesada (VH) y un dominio variable de la cadena liviana que comprende CDR seleccionadas de (1) CDR de SEQ ID NO: 85, 86, 87, 81, 82 y 83; o (2) CDR de SEQ ID NO: 85, 89, 87, 81, 82 y 83; o (3) CDR de SEQ ID NO: 85, 86, 87, 81, 82 y 91; o (4) CDR de SEQ ID NO: 85, 89, 87, 81, 82 y 91.
CR20260043A 2023-08-09 2024-08-06 Anticuerpos anti-proteína a-beta, métodos y usos de estos CR20260043A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP23190645 2023-08-09
PCT/EP2024/072205 WO2025032070A1 (en) 2023-08-09 2024-08-06 Anti-a-beta protein antibodies, methods and uses thereof

Publications (1)

Publication Number Publication Date
CR20260043A true CR20260043A (es) 2026-03-26

Family

ID=87567403

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20260043A CR20260043A (es) 2023-08-09 2024-08-06 Anticuerpos anti-proteína a-beta, métodos y usos de estos

Country Status (14)

Country Link
US (1) US20250051429A1 (es)
EP (1) EP4758169A1 (es)
JP (1) JP2025026427A (es)
KR (1) KR20260051039A (es)
CN (1) CN121620524A (es)
AR (1) AR133487A1 (es)
AU (1) AU2024322991A1 (es)
CL (1) CL2026000269A1 (es)
CO (1) CO2026000998A2 (es)
CR (1) CR20260043A (es)
IL (1) IL325709A (es)
MX (1) MX2026001340A (es)
TW (1) TW202513585A (es)
WO (1) WO2025032070A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL293018A (en) * 2019-11-22 2022-07-01 Lilly Co Eli trem2 antibodies and their uses

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Also Published As

Publication number Publication date
KR20260051039A (ko) 2026-04-15
IL325709A (en) 2026-02-01
EP4758169A1 (en) 2026-06-17
JP2025026427A (ja) 2025-02-21
AR133487A1 (es) 2025-10-01
CN121620524A (zh) 2026-03-06
MX2026001340A (es) 2026-03-02
CO2026000998A2 (es) 2026-03-05
TW202513585A (zh) 2025-04-01
WO2025032070A1 (en) 2025-02-13
AU2024322991A1 (en) 2026-01-08
CL2026000269A1 (es) 2026-04-24
US20250051429A1 (en) 2025-02-13