MA29966B1 - Traitement des tumeurs neuroendocrines - Google Patents
Traitement des tumeurs neuroendocrinesInfo
- Publication number
- MA29966B1 MA29966B1 MA30950A MA30950A MA29966B1 MA 29966 B1 MA29966 B1 MA 29966B1 MA 30950 A MA30950 A MA 30950A MA 30950 A MA30950 A MA 30950A MA 29966 B1 MA29966 B1 MA 29966B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- neuroendocrine tumors
- tumors
- administration
- possibly
- Prior art date
Links
- 201000011519 neuroendocrine tumor Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 229940124302 mTOR inhibitor Drugs 0.000 abstract 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE UN PROCÉDÉ DE TRAITEMENT DES TUMEURS ENDOCRINES, QUI COMPREND L'ADMINISTRATION D'UN INHIBITEUR DE MTOR, ÉVENTUELLEMENT EN ASSOCIATION AVEC UN AUTRE MÉDICAMENT.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0523658A GB0523658D0 (en) | 2005-11-21 | 2005-11-21 | Organic compounds |
| GB0601082A GB0601082D0 (en) | 2006-01-19 | 2006-01-19 | Organic Compounds |
| GB0602747A GB0602747D0 (en) | 2006-02-10 | 2006-02-10 | Organic compounds |
| GB0607942A GB0607942D0 (en) | 2006-04-21 | 2006-04-21 | Organic compounds |
| GB0609272A GB0609272D0 (en) | 2006-05-10 | 2006-05-10 | Organic compounds |
| GB0609912A GB0609912D0 (en) | 2006-05-18 | 2006-05-18 | Organic compounds |
| EP06120660 | 2006-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA29966B1 true MA29966B1 (fr) | 2008-11-03 |
Family
ID=37671355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30950A MA29966B1 (fr) | 2005-11-21 | 2008-05-20 | Traitement des tumeurs neuroendocrines |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9006224B2 (fr) |
| EP (3) | EP2022498A3 (fr) |
| JP (3) | JP2009516671A (fr) |
| KR (2) | KR20080071600A (fr) |
| CN (1) | CN103446138A (fr) |
| AU (2) | AU2006314444C1 (fr) |
| BR (1) | BRPI0618808A2 (fr) |
| CA (2) | CA2933875C (fr) |
| CY (1) | CY1115299T1 (fr) |
| DK (1) | DK2275103T3 (fr) |
| ES (1) | ES2481671T3 (fr) |
| HR (1) | HRP20140708T1 (fr) |
| IL (3) | IL191475A (fr) |
| MA (1) | MA29966B1 (fr) |
| NO (4) | NO346575B1 (fr) |
| NZ (1) | NZ568182A (fr) |
| PL (1) | PL2275103T3 (fr) |
| PT (1) | PT2275103E (fr) |
| RU (1) | RU2487711C2 (fr) |
| SI (1) | SI2275103T1 (fr) |
| WO (1) | WO2007057457A2 (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL409579A1 (pl) | 2001-02-19 | 2015-03-02 | Novartis Ag | Leczenie raka |
| CA2645633A1 (fr) * | 2006-04-05 | 2007-11-01 | Novartis Ag | Combinaisons d'agents therapeutiques pour traiter un cancer |
| EP2606890A1 (fr) * | 2006-04-05 | 2013-06-26 | Novartis AG | Combinaisons d'inhibiteurs de BCR-ABL/C-KIT/PDGF-R TK pour traiter le cancer |
| AU2013205002B2 (en) * | 2008-03-21 | 2016-09-15 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| EP2278966B1 (fr) * | 2008-03-21 | 2019-10-09 | The University of Chicago | Traitement avec des antagonistes des opioïdes et des inhibiteurs mtor |
| CN102176900B (zh) | 2008-09-17 | 2017-09-26 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| US9057054B2 (en) | 2009-06-25 | 2015-06-16 | The Regents Of The University Of Michigan | Antigen-specific long-term memory T-cells |
| PT3354652T (pt) | 2010-03-10 | 2020-07-20 | Incyte Holdings Corp | Derivados de piperidin-4-ilazetidina como inibidores de jak1 |
| KR101978537B1 (ko) * | 2011-10-19 | 2019-05-14 | 시그날 파마소티칼 엘엘씨 | Tor 키나제 억제제를 사용한 암의 치료 |
| EP2961408A1 (fr) * | 2013-02-28 | 2016-01-06 | Signal Pharmaceuticals, LLC | Traitement du cancer avec des inhibiteurs de la kinase tor |
| WO2014144405A1 (fr) * | 2013-03-15 | 2014-09-18 | The Board Of Regents Of The University Of Texas System | Utilisation d'inhibiteurs de mtor pour la prévention du développement et de la croissance d'une tumeur neuroendocrine |
| EP3003313A1 (fr) | 2013-05-29 | 2016-04-13 | Signal Pharmaceuticals, LLC | Compositions pharmaceutiques a base de 7-(6-(2-hydroxypropan-2-yl) pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b] pyrazin-2(1h)-one, forme solide et utilisations |
| AU2014373683B2 (en) | 2013-12-31 | 2020-05-07 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| HUE071943T2 (hu) | 2015-02-03 | 2025-10-28 | Amryt Endo Inc | Akromegália kezelése oktreotid orális alkalmazásával |
| US11045436B2 (en) * | 2015-06-30 | 2021-06-29 | Shanghai Jiao Tong University | Applications for sulindac in preparing anti-lung cancer products |
| WO2017127710A1 (fr) * | 2016-01-21 | 2017-07-27 | Chiasma Inc. | Octréotide par voie orale pour le traitement de maladies |
| WO2018204477A1 (fr) * | 2017-05-02 | 2018-11-08 | Cornell University | Procédés et réactifs pour ciblage de tumeur avec une efficacité améliorée et une toxicité réduite |
| EP3641772B1 (fr) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Traitement du carcinome hépatocellulaire caractérisé par une infection par le virus de l'hépatite b |
| US20210024542A1 (en) * | 2018-02-09 | 2021-01-28 | Torcept Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of cancer |
| IL300091A (en) | 2018-05-01 | 2023-03-01 | Revolution Medicines Inc | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
| CN112368289B (zh) | 2018-05-01 | 2024-02-20 | 锐新医药公司 | 作为mtor抑制剂的c26-连接的雷帕霉素类似物 |
| US12090145B2 (en) * | 2018-08-20 | 2024-09-17 | Yale University | Combination therapy for treating or preventing depression or other mood diseases |
| WO2020191002A1 (fr) * | 2019-03-18 | 2020-09-24 | The Regents Of The University Of California | Compositions et procédés pour le traitement d'une maladie de cushing |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
| CN117412772A (zh) * | 2021-06-07 | 2024-01-16 | 纳米药业有限责任公司 | 用于双靶向治疗神经内分泌瘤的组合物和方法 |
| US11723888B2 (en) | 2021-12-09 | 2023-08-15 | Nanopharmaceuticals Llc | Polymer conjugated thyrointegrin antagonists |
| EP4525836A4 (fr) | 2022-05-18 | 2026-02-25 | Hadasit Medical Res Services&Development Ltd | Combinaison d'endocannabinoïdes et d'inhibiteurs de mtor dans le traitement de néoplasmes neuroendocriniens |
| AU2023275778A1 (en) | 2022-05-25 | 2024-12-12 | Revolution Medicines, Inc. | Methods of treating cancer with an mtor inhibitor |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100172B1 (fr) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Dérivés d'amides |
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| US5010099A (en) | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| GB9013448D0 (en) * | 1990-06-15 | 1990-08-08 | Sandoz Ltd | Pharmaceutical resorption-improved somatostatin compositions,their preparation and use |
| PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| TW225528B (fr) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
| US5234140A (en) | 1992-07-28 | 1993-08-10 | S. C. Johnson & Son, Inc. | Re-useable aerosol container |
| BR9207175A (pt) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| PE52896A1 (es) | 1994-10-26 | 1996-12-12 | Novartis Ag | Composicion farmaceutica |
| MX9707453A (es) | 1995-03-30 | 1997-12-31 | Pfizer | Derivados de quinazolina. |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| MX9800215A (es) | 1995-07-06 | 1998-03-31 | Novartis Ag | Pirrolopirimidas y procesos para su preparacion. |
| IT1277391B1 (it) * | 1995-07-28 | 1997-11-10 | Romano Deghenghi | Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| HU228446B1 (en) | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| ATE233098T1 (de) | 1996-06-11 | 2003-03-15 | Novartis Ag | Kombination eines somatostatin analogs und eines rapamycins |
| EP0907642B1 (fr) | 1996-06-24 | 2005-11-02 | Pfizer Inc. | Derives tricycliques substitues par phenylamino, destines au traitement des maladies hyperproliferatives |
| US5932613A (en) | 1996-07-03 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Anticancer agents |
| US6258823B1 (en) | 1996-07-12 | 2001-07-10 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| EP0923583A1 (fr) | 1996-08-30 | 1999-06-23 | Novartis AG | Procede de fabrication d'epothilones, et composes intermediaires obtenus au cours de ce procede |
| DE19638745C2 (de) | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
| CA2265630A1 (fr) | 1996-09-13 | 1998-03-19 | Gerald Mcmahon | Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs |
| EP0837063A1 (fr) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | Dérivés de 4-aminoquinazoline |
| DK1367057T3 (da) | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| DE69927790T2 (de) | 1998-02-25 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen |
| ATE459616T1 (de) | 1998-08-11 | 2010-03-15 | Novartis Ag | Isochinoline derivate mit angiogenesis-hemmender wirkung |
| UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| NZ511722A (en) | 1998-11-20 | 2004-05-28 | Kosan Biosciences Inc | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| WO2000037502A2 (fr) | 1998-12-22 | 2000-06-29 | Genentech, Inc. | Antagonistes du facteur de croissance endotheliale et leurs utilisations |
| WO2000059509A1 (fr) | 1999-03-30 | 2000-10-12 | Novartis Ag | Derives de phtalazine pour le traitement des maladies inflammatoires |
| AU783158B2 (en) | 1999-08-24 | 2005-09-29 | Ariad Pharmaceuticals, Inc. | 28-epirapalogs |
| RU2264405C2 (ru) | 1999-12-06 | 2005-11-20 | Новартис Аг | 40-o-(2-гидрокси)этилрапамицин в кристаллической несольватированной форме, фармацевтическая композиция, содержащая такой макролид в качестве действующего вещества, и способ его получения |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| AU2002221810B2 (en) | 2000-11-07 | 2005-06-23 | Novartis Ag | Indolylmaleimide derivatives as protein kinase C inhibitors |
| TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| PL409579A1 (pl) * | 2001-02-19 | 2015-03-02 | Novartis Ag | Leczenie raka |
| TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
| TWI296196B (en) | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
| EP1385551B1 (fr) | 2001-04-06 | 2008-09-03 | Wyeth | Combinaisons antineoplasiques contenants du cci-779 (derivée de rapamycine) associe a la gemcitabine ou au fluorouracile |
| EA007530B1 (ru) * | 2001-06-01 | 2006-10-27 | Уайт | Противоопухолевые комбинации |
| US20030008923A1 (en) | 2001-06-01 | 2003-01-09 | Wyeth | Antineoplastic combinations |
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| JP4547911B2 (ja) | 2002-02-01 | 2010-09-22 | アリアド・ファーマシューティカルズ・インコーポレイテッド | リン含有化合物およびその用途 |
| PE20040079A1 (es) | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
| AU2003248813A1 (en) | 2002-07-05 | 2004-01-23 | Beth Israel Deaconess Medical Center | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
| JP2006514021A (ja) | 2002-12-09 | 2006-04-27 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム | Janusチロシンキナーゼ3(Jak3)を選択的に阻害するための方法 |
| UA83484C2 (uk) | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
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| MXPA06007174A (es) | 2003-12-22 | 2006-08-23 | Novartis Ag | Biomarcadores para determinar la sensibilidad de enfermedades proliferativas a inhibidores mtor. |
| NZ546058A (en) | 2004-01-12 | 2010-09-30 | Ym Biosciences Australia Pty | Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors |
| US20060035907A1 (en) * | 2004-02-23 | 2006-02-16 | Christensen James G | Methods of treating abnormal cell growth using c-MET and m-TOR inhibitors |
| US7749698B2 (en) | 2004-02-23 | 2010-07-06 | Novartis Ag | p53 wild-type as biomarker for the treatment with mTOR inhibitors in combination with a cytotoxic agent |
| US8975248B2 (en) | 2004-12-15 | 2015-03-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combinations of therapeutic agents for treating cancer |
| WO2006071966A2 (fr) * | 2004-12-29 | 2006-07-06 | The Brigham And Women's Hospital, Inc. | Composes de rapamycine traitant la neurofibromatose de type 1 |
-
2006
- 2006-11-20 RU RU2008124827/15A patent/RU2487711C2/ru active
- 2006-11-20 JP JP2008540626A patent/JP2009516671A/ja not_active Withdrawn
- 2006-11-20 CA CA2933875A patent/CA2933875C/fr active Active
- 2006-11-20 EP EP08162295A patent/EP2022498A3/fr not_active Withdrawn
- 2006-11-20 AU AU2006314444A patent/AU2006314444C1/en active Active
- 2006-11-20 KR KR1020087014937A patent/KR20080071600A/ko not_active Ceased
- 2006-11-20 NO NO20170956A patent/NO346575B1/no unknown
- 2006-11-20 BR BRPI0618808-7A patent/BRPI0618808A2/pt not_active Application Discontinuation
- 2006-11-20 KR KR1020147001555A patent/KR20140012218A/ko not_active Ceased
- 2006-11-20 PT PT101751972T patent/PT2275103E/pt unknown
- 2006-11-20 CA CA2629245A patent/CA2629245C/fr active Active
- 2006-11-20 SI SI200631791T patent/SI2275103T1/sl unknown
- 2006-11-20 ES ES10175197.2T patent/ES2481671T3/es active Active
- 2006-11-20 US US12/094,173 patent/US9006224B2/en active Active
- 2006-11-20 EP EP10175197.2A patent/EP2275103B1/fr not_active Revoked
- 2006-11-20 NO NO20220050A patent/NO20220050A1/no not_active Application Discontinuation
- 2006-11-20 EP EP06819607A patent/EP1954269A2/fr not_active Withdrawn
- 2006-11-20 PL PL10175197T patent/PL2275103T3/pl unknown
- 2006-11-20 WO PCT/EP2006/068656 patent/WO2007057457A2/fr not_active Ceased
- 2006-11-20 DK DK10175197.2T patent/DK2275103T3/da active
- 2006-11-20 NZ NZ568182A patent/NZ568182A/en unknown
- 2006-11-20 CN CN2013103848215A patent/CN103446138A/zh active Pending
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2008
- 2008-05-15 IL IL191475A patent/IL191475A/en active IP Right Grant
- 2008-05-20 MA MA30950A patent/MA29966B1/fr unknown
- 2008-06-16 NO NO20082683A patent/NO344288B1/no unknown
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2010
- 2010-07-07 AU AU2010202866A patent/AU2010202866A1/en not_active Abandoned
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2013
- 2013-04-03 JP JP2013077748A patent/JP5833048B2/ja active Active
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2014
- 2014-06-20 CY CY20141100454T patent/CY1115299T1/el unknown
- 2014-07-22 HR HRP20140708TT patent/HRP20140708T1/hr unknown
- 2014-12-03 JP JP2014245402A patent/JP5963836B2/ja active Active
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2015
- 2015-01-29 US US14/608,644 patent/US20150148294A1/en not_active Abandoned
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2016
- 2016-06-22 NO NO20161045A patent/NO341023B1/no unknown
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2017
- 2017-01-13 US US15/405,501 patent/US20170128425A1/en not_active Abandoned
- 2017-02-21 IL IL250697A patent/IL250697A0/en unknown
- 2017-07-27 IL IL253698A patent/IL253698A0/en unknown
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