CR9918A - Derivados de pirazolo[1,5-alfa]pirimidinilo utiles como antagonistas de receptor de factor liberador de corticotropina - Google Patents

Derivados de pirazolo[1,5-alfa]pirimidinilo utiles como antagonistas de receptor de factor liberador de corticotropina

Info

Publication number: CR9918A
Authority: CR; Costa Rica
Prior art keywords: antigonist; pirazolo; pyrimidinyl; alpha; derivatives
Prior art date: 2005-09-30

Application number

CR9918A

Other languages

English (en)

Inventor

Frank Hossner

Original Assignee

Neurocrine Biosciences Inc

Bayer Cropsciense Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-30

Filing date

2008-04-23

Publication date

2009-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35395069&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR9918(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-04-23 Application filed by Neurocrine Biosciences Inc, Bayer Cropsciense Ag filed Critical Neurocrine Biosciences Inc

2009-02-03 Publication of CR9918A publication Critical patent/CR9918A/es

Links

-1 PYRIMIDINYL Chemical class 0.000 title 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
239000003488 releasing hormone Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CR9918A 2005-09-30 2008-04-23 Derivados de pirazolo[1,5-alfa]pirimidinilo utiles como antagonistas de receptor de factor liberador de corticotropina CR9918A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0519957.5A GB0519957D0 (en)	2005-09-30	2005-09-30	Chemical compound

Publications (1)

Publication Number	Publication Date
CR9918A true CR9918A (es)	2009-02-03

Family

ID=35395069

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CR9918A CR9918A (es)	2005-09-30	2008-04-23	Derivados de pirazolo[1,5-alfa]pirimidinilo utiles como antagonistas de receptor de factor liberador de corticotropina

Country Status (21)

Country	Link
US (1)	US7879862B2 (es)
EP (2)	EP1802627B1 (es)
JP (2)	JP4901744B2 (es)
KR (2)	KR20070088621A (es)
CN (1)	CN101273043B (es)
AR (2)	AR051461A1 (es)
AU (2)	AU2005295353B2 (es)
BR (1)	BRPI0616767A2 (es)
CA (2)	CA2584567C (es)
CR (1)	CR9918A (es)
EA (1)	EA200801000A1 (es)
GB (1)	GB0519957D0 (es)
IL (1)	IL190225A0 (es)
MA (1)	MA29850B1 (es)
NO (2)	NO20072541L (es)
NZ (1)	NZ554082A (es)
PE (2)	PE20060586A1 (es)
RU (1)	RU2007118683A (es)
TW (2)	TW200626599A (es)
UA (1)	UA92756C2 (es)
WO (2)	WO2006044958A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7196078B2 (en)	2002-09-04	2007-03-27	Schering Corpoartion	Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
AR046967A1 (es) *	2003-12-22	2006-01-04	Sb Pharmco Inc	Compuesto de pirazol[1,5-a]pirimidina, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
GB0519957D0 (en) *	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
US7579360B2 (en)	2005-06-09	2009-08-25	Bristol-Myers Squibb Company	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7572807B2 (en)	2005-06-09	2009-08-11	Bristol-Myers Squibb Company	Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
US8088779B2 (en)	2005-09-30	2012-01-03	Smithkline Beecham (Cork) Limited	Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
US8119658B2 (en)	2007-10-01	2012-02-21	Bristol-Myers Squibb Company	Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CN101932583A (zh)	2007-12-19	2010-12-29	沃泰克斯药物股份有限公司	用作JAK2抑制剂的吡唑并[1,5-a]嘧啶类
BRPI0911659B8 (pt)	2008-04-15	2021-05-25	Eisai R&D Man Co Ltd	composto 3-fenilpirazolo[5,1-b]tiazol e composição farmacêutica compreendendo o mesmo
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
AR078521A1 (es)	2009-10-08	2011-11-16	Eisai R&D Man Co Ltd	Compuesto pirazolotiazol
JPWO2011043387A1 (ja) *	2009-10-08	2013-03-04	エーザイ・アール・アンド・ディー・マネジメント株式会社	ピラゾロオキサゾール化合物
AR080056A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de ciclohexil-amida como antagonistas de los receptores de crf
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
JP5748777B2 (ja)	2010-02-02	2015-07-15	ノバルティスアーゲー	Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
US8546416B2 (en)	2011-05-27	2013-10-01	Novartis Ag	3-spirocyclic piperidine derivatives as ghrelin receptor agonists
US20140309226A1 (en)	2011-11-16	2014-10-16	Array Biopharma Inc.	Piperidinyl-substituted cyclic ureas as gpr119 modulators
WO2013160317A2 (en) *	2012-04-23	2013-10-31	Holsboermaschmeyer Neurochemie Gmbh	Crhr1 antagonists for use in the treatment of patients having crh overactivity
CA2867043A1 (en)	2012-05-03	2013-11-07	Novartis Ag	L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
RU2718918C2 (ru)	2014-01-21	2020-04-15	Ньюрокрайн Байосайенсиз, Инк.	Антагонисты рецептора cfr1 для лечения врожденной гиперплазии коры надпочечников
CN106061975B (zh) *	2014-01-22	2019-09-24	库洛维公司	作为抗病毒化合物的吡唑并[1,5-a]嘧啶
KR102662065B1 (ko)	2017-02-17	2024-05-07	트레베나, 인코포레이티드.	7-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법
WO2018165520A1 (en)	2017-03-10	2018-09-13	Vps-3, Inc.	Metalloenzyme inhibitor compounds
BR112021010847A2 (pt)	2018-12-07	2021-09-08	Neurocrine Biosciences Inc.	Antagonista de receptor de crf1, formulações farmacêuticas e formas sólidas das mesmas para o tratamento de hiperplasia adrenal congênita
CN114727974A (zh)	2019-07-30	2022-07-08	艾科尼佐治疗股份有限公司	Hdac6抑制剂及其用途
US12383536B2 (en)	2019-09-27	2025-08-12	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods of use
EP4076448A4 (en)	2019-12-20	2024-03-27	Tenaya Therapeutics, Inc.	Fluoroalkyl-oxadiazoles and uses thereof
EP4236939A4 (en) *	2020-10-27	2024-08-07	Trevena, Inc.	Crystalline and amorphous forms of a delta-opioid modulator
EP4333841A1 (en)	2021-05-04	2024-03-13	Tenaya Therapeutics, Inc.	2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4605642A (en)	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
EP0714898B1 (en)	1994-06-21	2001-11-14	Otsuka Pharmaceutical Factory, Inc.	PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
DE880523T1 (de)	1996-02-07	2002-07-04	Janssen Pharmaceutica N.V., Beerse	Pyrazolopyrimidine als crf rezeptor-antagonisten
US6664261B2 (en)	1996-02-07	2003-12-16	Neurocrine Biosciences, Inc.	Pyrazolopyrimidines as CRF receptor antagonists
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
SK286461B6 (sk) *	1996-07-24	2008-10-07	Bristol-Myers Squibb Pharma Company	[1,5-a]-Pyrazolo-1,3,5-triazíny, ich použitie a farmaceutické kompozície na ich báze
HU229024B1 (en)	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
JPH10101672A (ja)	1996-08-06	1998-04-21	Otsuka Pharmaceut Factory Inc	アデノシン増強剤
JPH10101671A (ja)	1996-08-08	1998-04-21	Otsuka Pharmaceut Factory Inc	一酸化窒素合成酵素阻害剤
ES2273369T3 (es)	1996-08-28	2007-05-01	Pfizer Inc.	Derivados 6,5 heterobiciclicos sustituidos.
EP1049699B1 (en)	1998-01-28	2004-04-21	Bristol-Myers Squibb Pharma Company	Pyrazolotriazines as crf antagonists
JP2000038350A (ja)	1998-05-18	2000-02-08	Yoshitomi Pharmaceut Ind Ltd	糖尿病治療薬
EP1149835A4 (en)	1999-01-29	2002-08-21	Sumitomo Chemical Co	AGENTS FOR INHIBITATION OF FAT
AU4203500A (en) *	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
EP1218381B1 (en) *	1999-09-30	2006-12-06	Neurogen Corporation	AMINO SUBSTITUTED PYRAZOLO¬1,5-a\|-1,5-PYRIMIDINES AND PYRAZOLO¬1,5-a\|-1,3,5-TRIAZINES
JP2003510325A (ja)	1999-09-30	2003-03-18	ニューロジェン・コーポレーション	ある種のアルキレンジアミン−置換ピラゾロ［１，５−ａ］−１，５−ピリミジン及びピラゾロ［１，５−ａ］−１，３，５−トリアジン
IL139197A0 (en)	1999-10-29	2001-11-25	Pfizer Prod Inc	Use of corticotropin releasing factor antagonists and related compositions
CA2446514A1 (en) *	2001-04-30	2002-11-07	Glaxo Group Limited	Fused pyrimidines as antagonists of the corticotropin releasing factor (crf)
US7462622B2 (en) *	2001-06-12	2008-12-09	Glaxo Group Limited	Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists
GB0117396D0 (en)	2001-07-17	2001-09-05	Glaxo Group Ltd	Chemical compounds
AU2003240488A1 (en)	2002-06-04	2003-12-19	Neogenesis Pharmaceuticals, Inc.	Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
DE602004005960T2 (de) *	2003-01-16	2008-01-17	Sb Pharmco Puerto Rico Inc.	Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten
EP1608652A1 (en)	2003-03-31	2005-12-28	Vernalis (Cambridge) Limited	Pyrazolopyrimidine compounds and their use in medicine
US20070021429A1 (en) *	2003-04-09	2007-01-25	Yves St-Denis	Condensed n-heterocyclic compounds and their use as crf receptor antagonists
GB0308208D0 (en) *	2003-04-09	2003-05-14	Glaxo Group Ltd	Chemical compounds
JP2007515474A (ja) *	2003-12-22	2007-06-14	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	Ｃｒｆ受容体アンタゴニストおよびそれらに関連する方法
AR046967A1 (es) *	2003-12-22	2006-01-04	Sb Pharmco Inc	Compuesto de pirazol[1,5-a]pirimidina, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
DE102004008807A1 (de) *	2004-02-20	2005-09-08	Bayer Cropscience Ag	Pyrazolopyrimidine
GB0519957D0 (en) *	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
DE602005014375D1 (de) *	2004-10-19	2009-06-18	Neurocrine Biosciences Inc	Crf-rezeptor-antagonisten und zugehörige verfahren
US8088779B2 (en) *	2005-09-30	2012-01-03	Smithkline Beecham (Cork) Limited	Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists

2005
- 2005-09-30 GB GBGB0519957.5A patent/GB0519957D0/en not_active Ceased
- 2005-10-17 TW TW094136095A patent/TW200626599A/zh unknown
- 2005-10-17 AR ARP050104337A patent/AR051461A1/es not_active Application Discontinuation
- 2005-10-17 PE PE2005001219A patent/PE20060586A1/es not_active Application Discontinuation
- 2005-10-19 WO PCT/US2005/037576 patent/WO2006044958A1/en not_active Ceased
- 2005-10-19 NZ NZ554082A patent/NZ554082A/en not_active IP Right Cessation
- 2005-10-19 US US11/576,957 patent/US7879862B2/en active Active
- 2005-10-19 EP EP05818308A patent/EP1802627B1/en not_active Expired - Lifetime
- 2005-10-19 KR KR1020077008794A patent/KR20070088621A/ko not_active Ceased
- 2005-10-19 RU RU2007118683/04A patent/RU2007118683A/ru not_active Application Discontinuation
- 2005-10-19 CA CA2584567A patent/CA2584567C/en not_active Expired - Fee Related
- 2005-10-19 AU AU2005295353A patent/AU2005295353B2/en not_active Ceased
- 2005-10-19 JP JP2007537996A patent/JP4901744B2/ja not_active Expired - Lifetime
2006
- 2006-09-28 UA UAA200803939A patent/UA92756C2/ru unknown
- 2006-09-28 AR ARP060104269A patent/AR056104A1/es not_active Application Discontinuation
- 2006-09-28 AU AU2006298995A patent/AU2006298995B2/en not_active Ceased
- 2006-09-28 EP EP06805979A patent/EP1934222B1/en active Active
- 2006-09-28 EA EA200801000A patent/EA200801000A1/ru unknown
- 2006-09-28 TW TW095135886A patent/TW200745121A/zh unknown
- 2006-09-28 JP JP2008532687A patent/JP2009510004A/ja not_active Ceased
- 2006-09-28 CA CA002624699A patent/CA2624699A1/en not_active Abandoned
- 2006-09-28 KR KR1020087007620A patent/KR20080063760A/ko not_active Withdrawn
- 2006-09-28 BR BRPI0616767-5A patent/BRPI0616767A2/pt not_active IP Right Cessation
- 2006-09-28 PE PE2006001185A patent/PE20070845A1/es not_active Application Discontinuation
- 2006-09-28 CN CN2006800355977A patent/CN101273043B/zh not_active Expired - Fee Related
- 2006-09-28 WO PCT/EP2006/009531 patent/WO2007039264A1/en not_active Ceased
2007
- 2007-05-16 NO NO20072541A patent/NO20072541L/no not_active Application Discontinuation
2008
- 2008-03-17 IL IL190225A patent/IL190225A0/en unknown
- 2008-04-04 MA MA30813A patent/MA29850B1/fr unknown
- 2008-04-23 NO NO20081941A patent/NO20081941L/no not_active Application Discontinuation
- 2008-04-23 CR CR9918A patent/CR9918A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2624699A1 (en)	2007-04-12
CA2584567A1 (en)	2006-04-27
AR051461A1 (es)	2007-01-17
AU2005295353A1 (en)	2006-04-27
NO20081941L (no)	2008-04-23
WO2007039264A1 (en)	2007-04-12
PE20060586A1 (es)	2006-09-20
JP2009510004A (ja)	2009-03-12
EP1934222A1 (en)	2008-06-25
JP4901744B2 (ja)	2012-03-21
JP2008517067A (ja)	2008-05-22
US7879862B2 (en)	2011-02-01
EA200801000A1 (ru)	2009-02-27
AR056104A1 (es)	2007-09-19
KR20080063760A (ko)	2008-07-07
US20080194589A1 (en)	2008-08-14
RU2007118683A (ru)	2008-11-27
KR20070088621A (ko)	2007-08-29
EP1802627B1 (en)	2012-08-29
CA2584567C (en)	2013-04-30
PE20070845A1 (es)	2007-08-25
AU2006298995B2 (en)	2012-06-14
EP1802627A1 (en)	2007-07-04
UA92756C2 (ru)	2010-12-10
EP1934222B1 (en)	2012-07-25
MA29850B1 (fr)	2008-10-03
TW200745121A (en)	2007-12-16
TW200626599A (en)	2006-08-01
WO2006044958A1 (en)	2006-04-27
AU2006298995A1 (en)	2007-04-12
WO2006044958A8 (en)	2006-06-08
AU2005295353B2 (en)	2012-01-12
CN101273043A (zh)	2008-09-24
GB0519957D0 (en)	2005-11-09
NZ554082A (en)	2010-12-24
CN101273043B (zh)	2011-08-03
IL190225A0 (en)	2009-09-22
BRPI0616767A2 (pt)	2011-06-28
NO20072541L (no)	2007-06-25

Legal Events

Date	Code	Title	Description
2013-04-05	FA	Abandonment or withdrawal (granting procedure)

Publication	Publication Date	Title
CR9918A (es)	2009-02-03	Derivados de pirazolo[1,5-alfa]pirimidinilo utiles como antagonistas de receptor de factor liberador de corticotropina
MA28824B1 (fr)	2007-08-01	Derives de pyrimidine
MA28813B1 (fr)	2007-08-01	Derives de pyrimidine
IL188725A0 (en)	2008-08-07	Pyrazine derivatives useful as adenosine receptor antagonists
BRPI0716936A2 (pt)	2013-09-17	derivados de adenosina como antigonistas de receptor de a2a
NL2000323A1 (nl)	2007-06-21	Pyrimidine-derivaten.
CU23886B1 (es)	2013-04-19	Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteínas quinasas b
EP2154967A4 (en)	2010-05-19	Pyrimidine derivatives
ATE481409T1 (de)	2010-10-15	Thiazolopyramidin/pyridinharnstoffderivate als antagonisten am adenosin-a2b-rezeptor
BRPI0911688A2 (pt)	2015-07-28	"compostos de pirimidina, composições e métodos de uso"
DOP2007000068A (es)	2007-10-31	Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
DK1995242T3 (da)	2012-12-17	Hidtil ukendt 1,2,3,4-tetrahydroquinoxalinderivat med glucocorticoidreceptorbindingsaktivitet.
ZA200708187B (en)	2008-11-26	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-D]pyrimidine derivatives
CR20130209A (es)	2013-09-19	Derivados de carboxamida como antagonistas del receptor muscarinico
GB0525080D0 (en)	2006-01-18	Pyrimidine derivatives
GB0525083D0 (en)	2006-01-18	Pyrimidine derivatives
ATE454377T1 (de)	2010-01-15	2-phenyl-6-aminocarbonylpyrimidinderivate und ihre verwendung als antagonisten am p2y12- rezeptor
ATE538130T1 (de)	2012-01-15	Pyrimidinderivate und ihre verwendung als p2y12- rezeptorantagonisten
DE602006010508D1 (de)	2009-12-31	Substituierte triazolderivate als oxytocinantagonisten
ATE421511T1 (de)	2009-02-15	Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
ATE487718T1 (de)	2010-11-15	Substituierte bizyklische pyrimidonderivate
PT1355639E (pt)	2006-06-30	Derivados de carboestirilo substituidos como agonistas do subtipo de receptores 5-ht1a
ATE449080T1 (de)	2009-12-15	4-phenyl-6-substituierte pyrimidin-2- carbonitrilderivate
ATE513817T1 (de)	2011-07-15	Pyrimidinderivate und ihre verwendung als pestizide
GB0525081D0 (en)	2006-01-18	Pyrimidine derivatives