CR9986A - Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina - Google Patents

Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Info

Publication number
CR9986A
CR9986A CR9986A CR9986A CR9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A CR 9986 A CR9986 A CR 9986A
Authority
CR
Costa Rica
Prior art keywords
rapamycin
ester
boronate
preparation
procedure
Prior art date
Application number
CR9986A
Other languages
English (en)
Inventor
Chunhao Zhang
Clifford William Coughlin
Anthony Pilcher
Adam P Michaud
James S Farina
Ayman Sahli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37813522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR9986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9986A publication Critical patent/CR9986A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se provee un procedimiento graduable para la preparación de un 42-éster de rapamicina mediante la reacción de un boronato de 42-éster de rapamicina con un diol y la purificación de 42-éster de rapamicina crudo por recristalización y tratamiento con un diol; se provee también un método para aislar y purificar un boronato de 42-éster de rapamicina de soluciones madre que comprenden acetona y contaminantes de rapamicina.
CR9986A 2005-12-07 2008-05-19 Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina CR9986A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74814305P 2005-12-07 2005-12-07

Publications (1)

Publication Number Publication Date
CR9986A true CR9986A (es) 2008-08-21

Family

ID=37813522

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9986A CR9986A (es) 2005-12-07 2008-05-19 Procedimiento graduable para la preparación de un 42-ester de rapamicina a partir de un boronato de 42-ester de rapamicina

Country Status (18)

Country Link
US (1) US7622578B2 (es)
EP (1) EP1957501A2 (es)
JP (1) JP2009518412A (es)
KR (1) KR20080077619A (es)
CN (1) CN101321770A (es)
AR (1) AR058284A1 (es)
AU (1) AU2006322024A1 (es)
BR (1) BRPI0619578A2 (es)
CA (1) CA2630645A1 (es)
CR (1) CR9986A (es)
EC (1) ECSP088516A (es)
GT (1) GT200800087A (es)
IL (1) IL191550A0 (es)
NO (1) NO20082375L (es)
PE (1) PE20070748A1 (es)
RU (2) RU2008120670A (es)
TW (1) TW200804399A (es)
WO (1) WO2007067560A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2344821C2 (ru) * 2002-07-30 2009-01-27 Уайт Парентеральные композиции, содержащие гидроксиэфиры рапамицина
JP2009520818A (ja) * 2005-12-20 2009-05-28 ワイス 薬物物質不純物の制御によるｃｃｉ−７７９製剤安定性の制御
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
CN102020661B (zh) * 2011-01-07 2013-02-13 天津市炜杰科技有限公司 一种驮瑞塞尔合成方法
RU2603261C2 (ru) * 2011-04-01 2016-11-27 Сандоз Аг Региоселективное ацилирование рапамицина в положении с-42
US9446977B2 (en) 2012-12-10 2016-09-20 Corning Incorporated Method and system for making a glass article with uniform mold temperature
GB202415232D0 (en) 2024-10-16 2024-11-27 Nacamed As Composition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385908A (en) 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
JP2004509898A (ja) * 2000-09-19 2004-04-02 ワイス 水溶性ラパマイシンエステル
JP4227649B2 (ja) 2003-08-07 2009-02-18 ワイス Ｃｃｉ−７７９の位置選択的合成
EP1660081A1 (en) * 2003-09-03 2006-05-31 Wyeth Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and pharmaceutical compositions containing the same
EP1751168A1 (en) 2004-04-14 2007-02-14 Wyeth Proline cci-779 (proline-rapamycin 42-ester with 2,2-bis (hydroxymethyl) propionic acid) and two-step enzymatic synthesis of proline cci-779 and cci-779 using microbial lipase
PL1735321T3 (pl) * 2004-04-14 2009-04-30 Wyeth Corp Proces wytwarzania 42-estrów rapamycyny i 32-estrów FK-506 z kwasem dikarboksylowym, prekursory koniugatów rapamycyny oraz przeciwciała
KR20070015544A (ko) * 2004-04-14 2007-02-05 와이어쓰 라파마이신 42-에스테르 유도체의 위치특이성 합성
TW200616633A (en) * 2004-08-10 2006-06-01 Wyeth Corp CCI-779 derivatives and methods of making same
RU2394036C2 (ru) * 2004-12-20 2010-07-10 Вайет Аналоги рапамицина и их применение при лечении неврологических, пролиферативных и воспалительных заболеваний
EP1828203A2 (en) * 2004-12-20 2007-09-05 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
JP2008530090A (ja) * 2005-02-09 2008-08-07 ワイス Ｃｃｉ−７７９多形及びその使用
BRPI0607390A2 (pt) * 2005-03-02 2017-08-22 Wyeth Corp Processo para recuperar cci-779 de licores mâe
AU2006221024A1 (en) * 2005-03-07 2006-09-14 Wyeth Oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin

Also Published As

Publication number Publication date
WO2007067560A2 (en) 2007-06-14
NO20082375L (no) 2008-09-04
US20070129541A1 (en) 2007-06-07
JP2009518412A (ja) 2009-05-07
IL191550A0 (en) 2008-12-29
EP1957501A2 (en) 2008-08-20
RU2008120670A (ru) 2010-01-20
ECSP088516A (es) 2008-07-30
RU2008142554A (ru) 2010-05-10
US7622578B2 (en) 2009-11-24
GT200800087A (es) 2008-10-06
WO2007067560A3 (en) 2007-08-02
KR20080077619A (ko) 2008-08-25
BRPI0619578A2 (pt) 2011-10-04
CA2630645A1 (en) 2007-06-14
AU2006322024A1 (en) 2007-06-14
PE20070748A1 (es) 2007-08-08
TW200804399A (en) 2008-01-16
AR058284A1 (es) 2008-01-30
CN101321770A (zh) 2008-12-10

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)