DK1735321T3 - Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer - Google Patents

Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer

Info

Publication number: DK1735321T3
Authority: DK; Denmark
Prior art keywords: rapamycin; esters; dicarboxylic acid; precursors; antibodies
Prior art date: 2004-04-14

Application number

DK05735488T

Other languages

English (en)

Inventor

Jianxin Gu

Ping Cai

Mark E Ruppen

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-14

Filing date

2005-04-12

Publication date

2009-01-12

2005-04-12 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-01-12 Application granted granted Critical

2009-01-12 Publication of DK1735321T3 publication Critical patent/DK1735321T3/da

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 4
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 4
229960002930 sirolimus Drugs 0.000 title abstract 4
150000002148 esters Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title abstract 2
239000002243 precursor Substances 0.000 title 1
102000004882 Lipase Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DK05735488T 2004-04-14 2005-04-12 Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer DK1735321T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US56196604P	2004-04-14	2004-04-14
PCT/US2005/012268 WO2005105812A1 (en)	2004-04-14	2005-04-12	Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies

Publications (1)

Publication Number	Publication Date
DK1735321T3 true DK1735321T3 (da)	2009-01-12

Family

ID=34965703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05735488T DK1735321T3 (da)	2004-04-14	2005-04-12	Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer

Country Status (14)

Country	Link
US (2)	US7445916B2 (da)
EP (1)	EP1735321B1 (da)
JP (1)	JP2007532655A (da)
CN (1)	CN1942478A (da)
AT (1)	ATE410431T1 (da)
AU (1)	AU2005238432A1 (da)
BR (1)	BRPI0509810A (da)
CA (1)	CA2562962A1 (da)
DE (1)	DE602005010228D1 (da)
DK (1)	DK1735321T3 (da)
ES (1)	ES2313328T3 (da)
MX (1)	MXPA06011882A (da)
PL (1)	PL1735321T3 (da)
WO (1)	WO2005105812A1 (da)

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AU2014373683B2 (en)	2013-12-31	2020-05-07	Rapamycin Holdings, Llc	Oral rapamycin nanoparticle preparations and use
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2005
- 2005-04-12 AU AU2005238432A patent/AU2005238432A1/en not_active Withdrawn
- 2005-04-12 DE DE602005010228T patent/DE602005010228D1/de not_active Expired - Fee Related
- 2005-04-12 WO PCT/US2005/012268 patent/WO2005105812A1/en not_active Ceased
- 2005-04-12 PL PL05735488T patent/PL1735321T3/pl unknown
- 2005-04-12 ES ES05735488T patent/ES2313328T3/es not_active Expired - Lifetime
- 2005-04-12 CA CA002562962A patent/CA2562962A1/en not_active Abandoned
- 2005-04-12 EP EP05735488A patent/EP1735321B1/en not_active Expired - Lifetime
- 2005-04-12 MX MXPA06011882A patent/MXPA06011882A/es active IP Right Grant
- 2005-04-12 CN CNA200580011299XA patent/CN1942478A/zh not_active Withdrawn
- 2005-04-12 US US11/104,349 patent/US7445916B2/en not_active Expired - Lifetime
- 2005-04-12 JP JP2007508443A patent/JP2007532655A/ja not_active Withdrawn
- 2005-04-12 AT AT05735488T patent/ATE410431T1/de not_active IP Right Cessation
- 2005-04-12 DK DK05735488T patent/DK1735321T3/da active
- 2005-04-12 BR BRPI0509810-6A patent/BRPI0509810A/pt not_active IP Right Cessation
2008
- 2008-09-29 US US12/240,230 patent/US7625726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2005105812A1 (en)	2005-11-10
US20050234087A1 (en)	2005-10-20
ES2313328T3 (es)	2009-03-01
ATE410431T1 (de)	2008-10-15
CN1942478A (zh)	2007-04-04
US7625726B2 (en)	2009-12-01
PL1735321T3 (pl)	2009-04-30
BRPI0509810A (pt)	2007-09-18
CA2562962A1 (en)	2005-11-10
MXPA06011882A (es)	2006-12-14
AU2005238432A1 (en)	2005-11-10
EP1735321A1 (en)	2006-12-27
US7445916B2 (en)	2008-11-04
JP2007532655A (ja)	2007-11-15
DE602005010228D1 (de)	2008-11-20
EP1735321B1 (en)	2008-10-08
US20090029426A1 (en)	2009-01-29

Publication	Publication Date	Title
DK1735321T3 (da)	2009-01-12	Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer
WO2003082795A3 (en)	2003-12-24	METHODS OF MANUFACTURING DERIVATIVES OF β-HYDROXYCARBOXYLIC ACIDS
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TW200745015A (en)	2007-12-16	Process for the preparation of carboxylic acids and/or derivatives thereof
DE60015815D1 (de)	2004-12-16	Drehendes Reibungsschweissverfahren zur Herstellung eines Bauteils und provisorisches Schweissen von Teilen des Bauteils
EP1077212A4 (en)	2001-11-21	METHOD FOR PRODUCING VIVIVES OF 6-CYANOMETHYL-1,3-DIOXANE-4-ACETIC ACID
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ZA200603970B (en)	2007-08-29	Process for the production of metal salts of trifluoromethane sulphonic acid and their use as esterification catalysts
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DK1790718T3 (da)	2009-06-29	Pulverformig lipasesammensætning og fremgangsmåde til fremstilling af forestret produkt under anvendelse af samme
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