CS158391A3 - Factor precursor releasing pig growth-hormone - Google Patents

Factor precursor releasing pig growth-hormone Download PDF

Info

Publication number: CS158391A3
Authority: CS; Czechoslovakia
Prior art keywords: leu; gln; arg; ser; ala
Prior art date: 1990-05-29

Application number

CS911583A

Other languages

Czech (cs)

English (en)

Inventor

Ging Chan

Mark Louis Heiman

Hansen Maxwell Hsiung

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-29

Filing date

1991-05-27

Publication date

1992-01-15

1991-05-27 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1992-01-15 Publication of CS158391A3 publication Critical patent/CS158391A3/cs

Links

239000002243 precursor Substances 0.000 title description 32
101000868144 Sus scrofa Somatotropin Proteins 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 claims description 38
102000004196 processed proteins & peptides Human genes 0.000 claims description 35
229920001184 polypeptide Polymers 0.000 claims description 34
108020004414 DNA Proteins 0.000 claims description 29
150000003839 salts Chemical class 0.000 claims description 16
238000000034 method Methods 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 11
108010051696 Growth Hormone Proteins 0.000 claims description 9
102000018997 Growth Hormone Human genes 0.000 claims description 9
239000000122 growth hormone Substances 0.000 claims description 9
102000053602 DNA Human genes 0.000 claims description 8
150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 6
241001465754 Metazoa Species 0.000 claims description 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
150000001734 carboxylic acid salts Chemical class 0.000 claims description 3
239000001257 hydrogen Substances 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims description 3
-1 salt salts Chemical class 0.000 claims description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
150000001735 carboxylic acids Chemical class 0.000 claims description 2
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
230000001939 inductive effect Effects 0.000 claims description 2
108091028026 C-DNA Proteins 0.000 claims 1
150000007513 acids Chemical class 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
150000001875 compounds Chemical class 0.000 description 20
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 10
150000001413 amino acids Chemical group 0.000 description 9
239000000126 substance Substances 0.000 description 9
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
108090000623 proteins and genes Proteins 0.000 description 8
101710142969 Somatoliberin Proteins 0.000 description 6
102100022831 Somatoliberin Human genes 0.000 description 6
239000004471 Glycine Substances 0.000 description 5
239000004202 carbamide Substances 0.000 description 5
239000000463 material Substances 0.000 description 5
108700028369 Alleles Proteins 0.000 description 4
108091026890 Coding region Proteins 0.000 description 4
241000588724 Escherichia coli Species 0.000 description 4
239000000203 mixture Substances 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
108010076504 Protein Sorting Signals Proteins 0.000 description 3
241000282887 Suidae Species 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
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239000002552 dosage form Substances 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000011347 resin Substances 0.000 description 3
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239000000243 solution Substances 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
229920002684 Sepharose Polymers 0.000 description 2
150000003863 ammonium salts Chemical class 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
210000003527 eukaryotic cell Anatomy 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
239000013612 plasmid Substances 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
239000002904 solvent Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
239000013598 vector Substances 0.000 description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
108020004705 Codon Proteins 0.000 description 1
238000011537 Coomassie blue staining Methods 0.000 description 1
101100061188 Drosophila melanogaster dila gene Proteins 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
239000000095 Growth Hormone-Releasing Hormone Substances 0.000 description 1
101000825742 Homo sapiens Somatoliberin Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
241001494479 Pecora Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
241000282898 Sus scrofa Species 0.000 description 1
244000297179 Syringa vulgaris Species 0.000 description 1
235000004338 Syringa vulgaris Nutrition 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000005341 cation exchange Methods 0.000 description 1
KFGRVLINLVVMJA-MITYVQBRSA-N chembl440262 Chemical compound C([C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)C1=CC=C(O)C=C1 KFGRVLINLVVMJA-MITYVQBRSA-N 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
238000010367 cloning Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000002299 complementary DNA Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
108010091798 leucylleucine Proteins 0.000 description 1
239000002502 liposome Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
108010017391 lysylvaline Proteins 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
239000003488 releasing hormone Substances 0.000 description 1
210000003625 skull Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
108010056001 somatotropin releasing hormone (1-29) Proteins 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000008685 targeting Effects 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CS911583A 1990-05-29 1991-05-27 Factor precursor releasing pig growth-hormone CS158391A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53015090A	1990-05-29	1990-05-29

Publications (1)

Publication Number	Publication Date
CS158391A3 true CS158391A3 (en)	1992-01-15

Family

ID=24112624

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS911583A CS158391A3 (en)	1990-05-29	1991-05-27	Factor precursor releasing pig growth-hormone

Country Status (11)

Country	Link
EP (1)	EP0459747A1 (ja)
JP (1)	JPH0568559A (ja)
KR (1)	KR910020178A (ja)
AU (1)	AU639107B2 (ja)
CA (1)	CA2043049A1 (ja)
CS (1)	CS158391A3 (ja)
HU (1)	HUT58799A (ja)
IE (1)	IE911816A1 (ja)
IL (1)	IL98210A0 (ja)
NZ (1)	NZ238233A (ja)
ZA (1)	ZA913876B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS111292A3 (en) *	1991-04-19	1992-11-18	Lilly Co Eli	Dna compound encoding factor releasing growth-hormone of cattle and apharmaceutical composition containing said compound
CA2297375A1 (en) *	1997-07-24	1999-02-04	Valentis, Inc.	Ghrh expression system and methods of use
KR100358937B1 (ko) *	1998-04-23	2003-03-17	주식회사 엘지생명과학	성장호르몬 분비자극 활성을 가지는 수용성지모 추출물 및 그로부터 분리한 성장호르몬 분비촉진 인자
NZ566267A (en)	2003-05-01	2009-04-30	Merial Ltd	Canine GHRH gene, polypeptides and methods of use
US7468273B2 (en)	2003-05-01	2008-12-23	Meial Limited	Canine GHRH gene, polypeptides and methods of use
CN100404679C (zh) *	2005-09-23	2008-07-23	张永亮	GRF（1-32）与SS-HBsAg融合基因组合及其构建成的表达系统和药物制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0108387B1 (en) *	1982-11-04	1990-05-16	F. Hoffmann-La Roche Ag	Preparation of recombinant growth releasing factors
US4728609A (en) *	1983-01-10	1988-03-01	Hoffmann-La-Roche Inc.	Recombinant growth hormone releasing factor
US4610976A (en) *	1983-08-29	1986-09-09	The Salk Institute For Biological Studies	Porcine GRF
EP0212531A1 (en) *	1985-08-12	1987-03-04	Syntex (U.S.A.) Inc.	Bovine growth hormone releasing factor derivative

1991
- 1991-05-22 NZ NZ238233A patent/NZ238233A/en unknown
- 1991-05-22 ZA ZA913876A patent/ZA913876B/xx unknown
- 1991-05-22 CA CA002043049A patent/CA2043049A1/en not_active Abandoned
- 1991-05-22 IL IL98210A patent/IL98210A0/xx unknown
- 1991-05-24 JP JP3120153A patent/JPH0568559A/ja not_active Withdrawn
- 1991-05-27 CS CS911583A patent/CS158391A3/cs unknown
- 1991-05-27 KR KR1019910008644A patent/KR910020178A/ko not_active Ceased
- 1991-05-28 EP EP91304796A patent/EP0459747A1/en not_active Ceased
- 1991-05-28 HU HU911783A patent/HUT58799A/hu unknown
- 1991-05-28 AU AU78003/91A patent/AU639107B2/en not_active Ceased
- 1991-05-28 IE IE181691A patent/IE911816A1/en unknown

Also Published As

Publication number	Publication date
KR910020178A (ko)	1991-12-19
JPH0568559A (ja)	1993-03-23
HUT58799A (en)	1992-03-30
IL98210A0 (en)	1992-06-21
AU7800391A (en)	1991-12-05
CA2043049A1 (en)	1991-11-30
EP0459747A1 (en)	1991-12-04
NZ238233A (en)	1992-12-23
HU911783D0 (en)	1991-12-30
IE911816A1 (en)	1991-12-04
ZA913876B (en)	1993-01-27
AU639107B2 (en)	1993-07-15

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WO1993020203A2 (en)	1993-10-14	Stability-enhanced variants of parathyroid hormone
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TW200529868A (en)	2005-09-16	N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
US5416073A (en)	1995-05-16	Growth hormone-releasing peptides and method of treating animals, therewith
US7371844B2 (en)	2008-05-13	Nucleic acids encoding parathyroid hormone (PTH) derivatives
CS158391A3 (en)	1992-01-15	Factor precursor releasing pig growth-hormone
ES2316354T3 (es)	2009-04-16	Derivados polipeptidos de la hormona paratiroidea (pth).
JP2009545320A (ja)	2009-12-24	副甲状腺ホルモン（ｐｔｈ）のポリペプチド誘導体
AU625787B2 (en)	1992-07-16	Stabilized, potent grf analogs
AU660665B2 (en)	1995-07-06	Precursor form of bovine growth hormone releasing factor and related DNA compounds
WO2020165457A1 (en)	2020-08-20	Cortistatin or an analogue thereof as a pharmaceutically active agent in latent form
KR970009159B1 (ko)	1997-06-07	돼지 성장호르몬 동족체를 암호화하는 디엔에이
KR100233804B1 (ko)	1999-12-01	초활성 grf 유사체
NZ227770A (en)	1991-08-27	Growth hormone releasing factor (grf) peptide containing a cysteic acid residue in position 3 or 25
DE19508672A1 (de)	1996-09-12	Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
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