CS204011B2 - Process for preparing substituted pentapeptides - Google Patents

Process for preparing substituted pentapeptides Download PDF

Info

Publication number: CS204011B2
Authority: CS; Czechoslovakia
Prior art keywords: methyl; alanyl; tyrosyl; phenylalanyl; glycyl
Prior art date: 1976-09-27

Application number

CS776044A

Other languages

Czech (cs)

English (en)

Inventor

Edward L Smithwick

Robert C A Frederickson

Robert T Shuman

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-27

Filing date

1977-09-16

Publication date

1981-03-31

1977-09-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1981-03-31 Publication of CS204011B2 publication Critical patent/CS204011B2/cs

Links

238000004519 manufacturing process Methods 0.000 title description 2
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 69
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238000000034 method Methods 0.000 claims description 36
238000002360 preparation method Methods 0.000 claims description 31
-1 tert-amyloxycarbonyl Chemical group 0.000 claims description 31
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IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 21
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230000008569 process Effects 0.000 claims description 17
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 16
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C07K14/702—Enkephalins with at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
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Engineering & Computer Science (AREA)
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Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CS776044A 1976-09-27 1977-09-16 Process for preparing substituted pentapeptides CS204011B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72672476A	1976-09-27	1976-09-27
US05/807,849 US4259234A (en)	1976-09-27	1977-06-20	Analgesic compounds

Publications (1)

Publication Number	Publication Date
CS204011B2 true CS204011B2 (en)	1981-03-31

Family

ID=27111374

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS776044A CS204011B2 (en)	1976-09-27	1977-09-16	Process for preparing substituted pentapeptides

Country Status (27)

Country	Link
US (1)	US4259234A (fr)
JP (1)	JPS5340736A (fr)
AR (1)	AR228937A1 (fr)
AT (1)	AT359219B (fr)
AU (1)	AU513702B2 (fr)
CA (1)	CA1201710A (fr)
CH (2)	CH636847A5 (fr)
CS (1)	CS204011B2 (fr)
DD (1)	DD132862A5 (fr)
DE (1)	DE2741393A1 (fr)
DK (1)	DK148904C (fr)
ES (1)	ES462658A1 (fr)
FR (1)	FR2365553A1 (fr)
GB (1)	GB1586521A (fr)
GR (1)	GR69224B (fr)
HK (1)	HK52681A (fr)
HU (1)	HU180723B (fr)
IE (1)	IE45576B1 (fr)
IL (1)	IL52872A (fr)
MY (1)	MY8200150A (fr)
NL (1)	NL7710502A (fr)
NZ (1)	NZ185084A (fr)
PL (1)	PL111136B1 (fr)
PT (1)	PT67026B (fr)
RO (1)	RO80379B (fr)
SE (1)	SE438339B (fr)
SU (1)	SU753358A3 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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US4261888A (en) *	1976-04-12	1981-04-14	Sandoz Ltd.	Organic compounds
ZA775285B (en) *	1976-09-01	1978-07-26	A Kastin	Novel methionine enkephalin derivatives
HU178001B (en) *	1976-09-16	1982-02-28	Gyogyszekutato Intezet	Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4322342A (en) *	1977-06-20	1982-03-30	Eli Lilly And Company	Analgesic compounds
EP0000559B1 (fr) *	1977-07-22	1983-10-05	The Wellcome Foundation Limited	Pentapeptide-N-alkoylamides et leurs sels, procédé de préparation de ces produits et leurs compositions pharmacologiques
US4264491A (en) *	1977-10-03	1981-04-28	Eli Lilly And Company	Analgesic compounds
FR2424253A1 (fr) *	1978-04-27	1979-11-23	Brun Lab Sa Le	Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
DE2933947A1 (de) *	1979-08-22	1981-03-12	Hoechst Ag, 6000 Frankfurt	Neue peptidamide und verfahren zu ihrer herstellung.
US4254024A (en) *	1979-10-16	1981-03-03	Pennwalt Corporation	Tetrapeptides and derivatives having opiate activity
US4351763A (en) *	1979-12-17	1982-09-28	Eli Lilly And Company	Pharmacologically active peptides
US4265808A (en) *	1979-12-17	1981-05-05	Eli Lilly And Company	Pharmacologically active peptides
US4251439A (en) *	1979-12-17	1981-02-17	Eli Lilly And Company	Pharmacologically active peptides
US4283330A (en) *	1979-12-17	1981-08-11	Eli Lilly And Company	Pharmacologically active peptides
US4283329A (en) *	1979-12-17	1981-08-11	Eli Lilly And Company	Pharmacologically active peptides
FR2488253A1 (fr) *	1980-08-08	1982-02-12	Roques Bernard	Nouveaux peptides et leur application en therapeutique
US4322339A (en) *	1980-10-20	1982-03-30	Eli Lilly And Company	Pharmacologically active peptides
EP0076557B1 (fr) *	1981-06-22	1985-11-13	Imperial Chemical Industries Plc	Peptides et pseudopeptides ayant au N-terminus deux substituants
US4430327A (en)	1982-05-18	1984-02-07	Eli Lilly And Company	Method for treating pregnant females for pain and anxiety
DE3915755A1 (de) *	1989-05-13	1990-11-29	Bayer Ag	Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
DE4102042A1 (de) *	1991-01-24	1992-07-30	Bayer Ag	Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
JPH09173654A (ja) *	1995-12-21	1997-07-08	Ritsuwa Yo	積木
EP1297830A1 (fr) *	2001-09-28	2003-04-02	Flamma Fabbrica Lombarda Ammino Acidi S.p.a.	L'utilisation des acides aminés alpha ou bèta, leurs esters, ou de dipeptides de ces acides aminés avec des dérivés d'histidine, dans la prévention ou le traitement de lésions de la peau causées par l'ozone atmosphérique

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GB1532181A (en) *	1976-02-02	1978-11-15	Beckman Instruments Inc	Pentapetides and a method of preparing them
FI770219A7 (fr) *	1976-02-02	1977-08-03	Sandoz Ag
NZ183712A (en) *	1976-04-08	1979-10-25	Ici Ltd	Polypeptide analogues of enkephalins, and pharmaceutical compositions
ZA775285B (en) *	1976-09-01	1978-07-26	A Kastin	Novel methionine enkephalin derivatives
HU178001B (en) *	1976-09-16	1982-02-28	Gyogyszekutato Intezet	Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4178371A (en) *	1977-12-15	1979-12-11	Reckitt & Colman Products Limited	Tetrapeptide derivatives

1977
- 1977-06-20 US US05/807,849 patent/US4259234A/en not_active Expired - Lifetime
- 1977-08-30 IE IE1805/77A patent/IE45576B1/en unknown
- 1977-09-01 GR GR54278A patent/GR69224B/el unknown
- 1977-09-01 IL IL52872A patent/IL52872A/xx unknown
- 1977-09-02 NZ NZ185084A patent/NZ185084A/xx unknown
- 1977-09-09 AU AU28565/77A patent/AU513702B2/en not_active Expired
- 1977-09-12 CA CA000286528A patent/CA1201710A/fr not_active Expired
- 1977-09-13 PT PT67026A patent/PT67026B/pt unknown
- 1977-09-14 DE DE19772741393 patent/DE2741393A1/de active Granted
- 1977-09-16 CS CS776044A patent/CS204011B2/cs unknown
- 1977-09-22 GB GB39459/77A patent/GB1586521A/en not_active Expired
- 1977-09-22 AR AR269298A patent/AR228937A1/es active
- 1977-09-23 CH CH1165977A patent/CH636847A5/de not_active IP Right Cessation
- 1977-09-26 NL NL7710502A patent/NL7710502A/xx not_active Application Discontinuation
- 1977-09-26 RO RO91664A patent/RO80379B/ro unknown
- 1977-09-26 PL PL1977201049A patent/PL111136B1/pl unknown
- 1977-09-26 ES ES462658A patent/ES462658A1/es not_active Expired
- 1977-09-26 SU SU772526421A patent/SU753358A3/ru active
- 1977-09-26 SE SE7710755A patent/SE438339B/sv not_active IP Right Cessation
- 1977-09-26 DK DK424577A patent/DK148904C/da not_active IP Right Cessation
- 1977-09-26 FR FR7728939A patent/FR2365553A1/fr active Granted
- 1977-09-26 DD DD7700201204A patent/DD132862A5/xx unknown
- 1977-09-26 AT AT685977A patent/AT359219B/de not_active IP Right Cessation
- 1977-09-26 HU HU77EI763A patent/HU180723B/hu unknown
- 1977-09-27 JP JP11659077A patent/JPS5340736A/ja active Granted
1981
- 1981-10-29 HK HK526/81A patent/HK52681A/xx unknown
1982
- 1982-12-30 MY MY150/82A patent/MY8200150A/xx unknown
1983
- 1983-03-09 CH CH128183A patent/CH643533A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATA685977A (de)	1980-03-15
RO80379A (fr)	1983-04-29
PL111136B1 (en)	1980-08-30
AU2856577A (en)	1979-03-15
PT67026B (en)	1979-02-14
JPS5340736A (en)	1978-04-13
NZ185084A (en)	1980-11-14
AR228937A1 (es)	1983-05-13
DE2741393C2 (fr)	1988-03-10
IE45576L (en)	1978-03-27
ES462658A1 (es)	1978-11-01
NL7710502A (nl)	1978-03-29
CA1201710A (fr)	1986-03-11
RO80379B (ro)	1983-04-30
SE438339B (sv)	1985-04-15
DD132862A5 (de)	1978-11-15
DE2741393A1 (de)	1978-03-30
HK52681A (en)	1981-11-06
IE45576B1 (en)	1982-10-06
US4259234A (en)	1981-03-31
PT67026A (en)	1977-10-01
SE7710755L (sv)	1978-03-28
DK424577A (da)	1978-03-28
AT359219B (de)	1980-10-27
MY8200150A (en)	1982-12-31
DK148904C (da)	1986-04-14
FR2365553B1 (fr)	1980-11-14
CH636847A5 (de)	1983-06-30
GR69224B (fr)	1982-05-10
CH643533A5 (de)	1984-06-15
HU180723B (en)	1983-04-29
FR2365553A1 (fr)	1978-04-21
GB1586521A (en)	1981-03-18
JPS6254800B2 (fr)	1987-11-17
PL201049A1 (pl)	1979-01-29
AU513702B2 (en)	1980-12-18
SU753358A3 (ru)	1980-07-30
IL52872A (en)	1983-07-31
DK148904B (da)	1985-11-11

Publication	Publication Date	Title
CS204011B2 (en)	1981-03-31	Process for preparing substituted pentapeptides
US5317014A (en)	1994-05-31	Peptides and pseudopeptides derived from tachykinin
US3832337A (en)	1974-08-27	Peptide enzyme inhibitors
US20240124517A1 (en)	2024-04-18	Method for producing peptide compound containing n-substituted-amino acid residue
US4472305A (en)	1984-09-18	Hexapeptide amides
CA2301687A1 (fr)	1999-02-25	Derives de phenylethylamine
JPH11292840A (ja)	1999-10-26	ノルスタチン誘導体又はその塩
US3740385A (en)	1973-06-19	N-terminal derivatives of secretin
KR0121793B1 (ko)	1997-11-27	L-프롤린 유도체, 이의 제조 방법 및 이를 함유하는 향정신성 생물학적 제제
EP0001684B1 (fr)	1981-09-02	Tétrapeptides, méthodes pour les préparer et leur application dans des compositions analgésiques
US6184345B1 (en)	2001-02-06	Branched building units for synthesizing cyclic peptides
US4407746A (en)	1983-10-04	Cyclohexyl and phenyl substituted enkephalins
US4322342A (en)	1982-03-30	Analgesic compounds
NZ198626A (en)	1984-02-03	Peptides and pharmaceutical compositions
US4092304A (en)	1978-05-30	4-Substituted enkephalin derivatives
Siemion et al.	1981	To the problem of biologically active conformation of enkephalin
HU185022B (en)	1984-11-28	Process for the preparation of biologically active tetrapeptide derivatives
Bańkowski et al.	2013	Synthesis, biological activity and resistance to proteolytic digestion of new cyclic dermorphin/deltorphin analogues
WO1993000359A1 (fr)	1993-01-07	Peptides modifies pouvant etre transportes vers le systeme nerveux central
HU190915B (en)	1986-12-28	Process for preparing new tripeptide derivatives
CA1178950A (fr)	1984-12-04	Obtention de (d-trp.sup.6)-lh-rh via l'heptapeptide de h-ser-tyr-d-trp-leu-arg-pro-gly-nh.sub.2
GB2130590A (en)	1984-06-06	Peptides
SE461042B (sv)	1989-12-18	Peptider med tillvaextbefraemjande aktivitet jaemte veterinaera kompositioner innehaallande naemnda peptider
JP2001505216A (ja)	2001-04-17	ブラジキニンｂ▲下２▼レセプターのペプチドアゴニスト
Ohno et al.	1970	Partial enzymic deprotection in the synthesis of a protected octapeptide bearing a free terminal carboxyl group