CS228142B2 - Preparation of molecular coordinating complex - Google Patents

Preparation of molecular coordinating complex Download PDF

Info

Publication number: CS228142B2
Authority: CS; Czechoslovakia
Prior art keywords: polymer; cellulose; alcohol; weight; solvent
Prior art date: 1979-12-19

Application number

CS809008A

Other languages

Czech (cs)

English (en)

Inventor

Stewart T Leslie

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-12-19

Filing date

1980-12-18

Publication date

1984-05-14

1980-12-18 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

1984-05-14 Publication of CS228142B2 publication Critical patent/CS228142B2/cs

Links

238000002360 preparation method Methods 0.000 title claims description 6
229920000642 polymer Polymers 0.000 claims abstract description 109
229920002678 cellulose Polymers 0.000 claims abstract description 79
239000001913 cellulose Substances 0.000 claims abstract description 77
239000000203 mixture Substances 0.000 claims abstract description 59
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims abstract description 32
239000007787 solid Substances 0.000 claims abstract description 24
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 22
239000002798 polar solvent Substances 0.000 claims abstract description 16
125000001931 aliphatic group Chemical group 0.000 claims abstract description 6
239000000155 melt Substances 0.000 claims abstract description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
239000002904 solvent Substances 0.000 claims description 42
238000000034 method Methods 0.000 claims description 24
150000004696 coordination complex Chemical class 0.000 claims description 17
230000008569 process Effects 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 13
125000003158 alcohol group Chemical group 0.000 claims description 7
101000687448 Homo sapiens REST corepressor 1 Proteins 0.000 claims description 2
102100024864 REST corepressor 1 Human genes 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
239000011159 matrix material Substances 0.000 abstract description 24
238000013270 controlled release Methods 0.000 abstract description 8
238000009472 formulation Methods 0.000 abstract description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 35
238000007614 solvation Methods 0.000 description 34
239000000243 solution Substances 0.000 description 29
239000001257 hydrogen Substances 0.000 description 27
229910052739 hydrogen Inorganic materials 0.000 description 27
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 25
238000006243 chemical reaction Methods 0.000 description 22
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 20
239000000126 substance Substances 0.000 description 20
239000003795 chemical substances by application Substances 0.000 description 19
229920003063 hydroxymethyl cellulose Polymers 0.000 description 18
229940031574 hydroxymethyl cellulose Drugs 0.000 description 18
HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 18
150000001875 compounds Chemical class 0.000 description 17
239000000499 gel Substances 0.000 description 15
239000003826 tablet Substances 0.000 description 15
239000004480 active ingredient Substances 0.000 description 14
150000002191 fatty alcohols Chemical class 0.000 description 13
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 11
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
239000002245 particle Substances 0.000 description 10
239000011148 porous material Substances 0.000 description 10
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 9
239000004354 Hydroxyethyl cellulose Substances 0.000 description 9
239000002775 capsule Substances 0.000 description 9
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 9
239000008187 granular material Substances 0.000 description 9
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 9
229940043348 myristyl alcohol Drugs 0.000 description 9
239000013543 active substance Substances 0.000 description 8
239000013522 chelant Substances 0.000 description 8
238000004132 cross linking Methods 0.000 description 8
230000000694 effects Effects 0.000 description 8
239000000454 talc Substances 0.000 description 8
229910052623 talc Inorganic materials 0.000 description 8
230000015572 biosynthetic process Effects 0.000 description 7
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 6
230000008859 change Effects 0.000 description 6
239000003085 diluting agent Substances 0.000 description 6
238000001035 drying Methods 0.000 description 6
239000001863 hydroxypropyl cellulose Substances 0.000 description 6
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 6
239000008101 lactose Substances 0.000 description 6
229920000609 methyl cellulose Polymers 0.000 description 6
239000001923 methylcellulose Substances 0.000 description 6
239000000047 product Substances 0.000 description 6
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
229920006037 cross link polymer Polymers 0.000 description 5
230000007423 decrease Effects 0.000 description 5
150000004676 glycans Polymers 0.000 description 5
230000003993 interaction Effects 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
239000008188 pellet Substances 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
229920003086 cellulose ether Polymers 0.000 description 4
230000000875 corresponding effect Effects 0.000 description 4
238000009792 diffusion process Methods 0.000 description 4
239000006185 dispersion Substances 0.000 description 4
239000002552 dosage form Substances 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000000314 lubricant Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229910052751 metal Inorganic materials 0.000 description 4
239000002184 metal Substances 0.000 description 4
239000002808 molecular sieve Substances 0.000 description 4
230000035699 permeability Effects 0.000 description 4
229920001282 polysaccharide Polymers 0.000 description 4
239000005017 polysaccharide Substances 0.000 description 4
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 4
239000012453 solvate Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
230000032683 aging Effects 0.000 description 3
-1 aliphatic alcohols Chemical class 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
239000003054 catalyst Substances 0.000 description 3
229940082500 cetostearyl alcohol Drugs 0.000 description 3
125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
238000005259 measurement Methods 0.000 description 3
239000001103 potassium chloride Substances 0.000 description 3
235000011164 potassium chloride Nutrition 0.000 description 3
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 3
229960005205 prednisolone Drugs 0.000 description 3
230000008961 swelling Effects 0.000 description 3
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
229920003043 Cellulose fiber Polymers 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
239000000006 Nitroglycerin Substances 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
239000000654 additive Substances 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
229920013820 alkyl cellulose Polymers 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
229920003064 carboxyethyl cellulose Polymers 0.000 description 2
229960000541 cetyl alcohol Drugs 0.000 description 2
239000007795 chemical reaction product Substances 0.000 description 2
238000001246 colloidal dispersion Methods 0.000 description 2
230000008602 contraction Effects 0.000 description 2
230000003111 delayed effect Effects 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000003337 fertilizer Substances 0.000 description 2
238000001879 gelation Methods 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
229960003711 glyceryl trinitrate Drugs 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
229920001059 synthetic polymer Polymers 0.000 description 2
239000012085 test solution Substances 0.000 description 2
238000011200 topical administration Methods 0.000 description 2
238000009827 uniform distribution Methods 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000005233 alkylalcohol group Chemical group 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
125000004181 carboxyalkyl group Chemical group 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
230000007797 corrosion Effects 0.000 description 1
238000005260 corrosion Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000004880 explosion Methods 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000013007 heat curing Methods 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
229910052738 indium Inorganic materials 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
229920005615 natural polymer Polymers 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
230000035515 penetration Effects 0.000 description 1
239000012466 permeate Substances 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000002831 pharmacologic agent Substances 0.000 description 1
231100000572 poisoning Toxicity 0.000 description 1
230000000607 poisoning effect Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000004848 polyfunctional curative Substances 0.000 description 1
150000004804 polysaccharides Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002243 precursor Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000000518 rheometry Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229920005613 synthetic organic polymer Polymers 0.000 description 1
229920001187 thermosetting polymer Polymers 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
239000002699 waste material Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B11/00—Preparation of cellulose ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/05—Alcohols; Metal alcoholates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Materials Engineering (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Medicinal Preparation (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Compositions Of Macromolecular Compounds (AREA)
Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

CS809008A 1979-12-19 1980-12-18 Preparation of molecular coordinating complex CS228142B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IE248179		1979-12-19
IE2480/79A IE49324B1 (en)	1979-12-19	1979-12-19	Controlled release compositions

Publications (1)

Publication Number	Publication Date
CS228142B2 true CS228142B2 (en)	1984-05-14

Family

ID=26319271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS809008A CS228142B2 (en)	1979-12-19	1980-12-18	Preparation of molecular coordinating complex

Country Status (27)

Country	Link
US (1)	US4366310A (no)
EP (1)	EP0032004B1 (no)
JP (1)	JPS5698201A (no)
AU (1)	AU541246B2 (no)
BE (1)	BE886711A (no)
CA (1)	CA1168230A (no)
CS (1)	CS228142B2 (no)
DE (1)	DE3048028A1 (no)
DK (1)	DK170347B1 (no)
EG (1)	EG14984A (no)
ES (1)	ES497906A0 (no)
FI (1)	FI66623C (no)
FR (1)	FR2474507B1 (no)
GB (1)	GB2067569B (no)
GR (1)	GR72265B (no)
HU (1)	HU188085B (no)
IE (1)	IE49324B1 (no)
IL (1)	IL61677A (no)
MX (1)	MX158088A (no)
NL (1)	NL187401C (no)
NO (1)	NO152846C (no)
NZ (1)	NZ195793A (no)
PL (1)	PL133079B1 (no)
PT (1)	PT72214B (no)
SU (1)	SU1178326A3 (no)
YU (1)	YU40957B (no)
ZA (1)	ZA807716B (no)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1211266A (en) *	1982-11-12	1986-09-16	Alfred E. Lauchenauer	Shaped semi-solid articles
DE3306621A1 (de) *	1983-02-25	1984-08-30	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von celluloseethern mit einem dimethoxyethan enthaltenden dispergierhilfsmittel
GB8514665D0 (en) *	1985-06-11	1985-07-10	Eroceltique Sa	Oral pharmaceutical composition
GB8613688D0 (en) *	1986-06-05	1986-07-09	Euro Celtique Sa	Pharmaceutical composition
ES2058111T3 (es) *	1986-06-10	1994-11-01	Euro Celtique Sa	Composicion de liberacion controlada de dihidrocodeina.
GB8626098D0 (en) *	1986-10-31	1986-12-03	Euro Celtique Sa	Controlled release hydromorphone composition
US5023080A (en) *	1988-06-17	1991-06-11	Basic Bio Systems, Inc.	Time release protein
US5055300A (en) *	1988-06-17	1991-10-08	Basic Bio Systems, Inc.	Time release protein
US5079005A (en) *	1988-06-17	1992-01-07	Gupta Kashmiri L	Time release protein
US5476668A (en) *	1990-08-24	1995-12-19	Shin-Etsu Chemical Co., Ltd.	Base for film-coating pharmaceuticals and method for preparing same
NZ260408A (en)	1993-05-10	1996-05-28	Euro Celtique Sa	Controlled release preparation comprising tramadol
US5891471A (en) *	1993-11-23	1999-04-06	Euro-Celtique, S.A.	Pharmaceutical multiparticulates
KR100354702B1 (ko) *	1993-11-23	2002-12-28	유로-셀티크 소시에떼 아노뉨	약학조성물의제조방법및서방형조성물
US5843480A (en) *	1994-03-14	1998-12-01	Euro-Celtique, S.A.	Controlled release diamorphine formulation
GB9422154D0 (en)	1994-11-03	1994-12-21	Euro Celtique Sa	Pharmaceutical compositions and method of producing the same
US5965161A (en)	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
AU8532798A (en) *	1997-06-13	1998-12-30	Roland Bodmeier	Compounds which delay the release of active substances
TR200001942T2 (tr)	1997-12-22	2000-11-21	Euro-Celtique, S.A.	Opioid agonist/antagonist kombinasyonlar
SI2283842T1 (sl)	2000-02-08	2015-07-31	Euro-Celtique S.A.	Oralne formulacije opioidnih agonistov, varne pred zlorabo
EP1387673B1 (en)	2001-05-11	2010-12-29	Endo Pharmaceuticals Inc.	Abuse-resistant controlled-release opioid dosage form
DK1416842T3 (da)	2001-07-18	2009-03-16	Euro Celtique Sa	Farmaceutiske kombinationer af oxycodon og naloxon
ES2326794T3 (es)	2001-08-06	2009-10-20	Euro-Celtique S.A.	Formulaciones de agonistas opioides con antagonista liberable y secuestrado.
US20030068375A1 (en)	2001-08-06	2003-04-10	Curtis Wright	Pharmaceutical formulation containing gelling agent
US20030044458A1 (en)	2001-08-06	2003-03-06	Curtis Wright	Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030157168A1 (en)	2001-08-06	2003-08-21	Christopher Breder	Sequestered antagonist formulations
LT2425821T (lt)	2002-04-05	2017-07-25	Euro-Celtique S.A.	Farmacinis preparatas, turintis oksikodono ir naloksono
SI1551372T1 (en)	2002-09-20	2018-08-31	Alpharma Pharmaceuticals Llc	SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES
US20040202717A1 (en)	2003-04-08	2004-10-14	Mehta Atul M.	Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en)	2003-04-21	2011-08-21	Euro Celtique Sa	Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
ES2653568T3 (es)	2004-06-12	2018-02-07	Collegium Pharmaceutical, Inc.	Formulaciones de fármacos para la prevención del abuso
EP1702558A1 (en)	2005-02-28	2006-09-20	Euro-Celtique S.A.	Method and device for the assessment of bowel function
SI2484346T1 (sl)	2006-06-19	2017-05-31	Alpharma Pharmaceuticals Llc	Farmacevtski sestavki
EP1897543A1 (en)	2006-08-30	2008-03-12	Euro-Celtique S.A.	Buprenorphine- wafer for drug substitution therapy
US8623418B2 (en)	2007-12-17	2014-01-07	Alpharma Pharmaceuticals Llc	Pharmaceutical composition
JP2010159364A (ja) *	2009-01-09	2010-07-22	Kyoto Univ	セルロースの高温での着色を抑制する方法
PL2405915T3 (pl)	2009-03-10	2019-05-31	Euro Celtique Sa	Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
US10668060B2 (en)	2009-12-10	2020-06-02	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
MX340188B (es) *	2010-05-10	2016-06-30	Euro-Celtique S A *	Elaboracion de granulos sin activos y tabletas que comprenden los mismos.
WO2011141490A1 (en)	2010-05-10	2011-11-17	Euro-Celtique S.A.	Combination of active loaded granules with additional actives
SG184523A1 (en)	2010-05-10	2012-11-29	Euro Celtique Sa	Pharmaceutical compositions comprising hydromorphone and naloxone
PL2826467T3 (pl)	2010-12-22	2018-01-31	Purdue Pharma Lp	Zamknięte, zabezpieczone przed manipulowaniem formy dozowania o kontrolowanym uwalnianiu
PH12013501345A1 (en)	2010-12-23	2022-10-24	Purdue Pharma Lp	Tamper resistant solid oral dosage forms
PE20151301A1 (es)	2013-02-05	2015-09-16	Purdue Pharma Lp	Formulaciones farmaceuticas resistentes a la manipulacion indebida
US10751287B2 (en)	2013-03-15	2020-08-25	Purdue Pharma L.P.	Tamper resistant pharmaceutical formulations
KR20160034352A (ko)	2013-07-23	2016-03-29	유로-셀티큐 에스.에이.	장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
JP6232135B2 (ja)	2013-11-13	2017-11-15	ユーロ−セルティークエス．エイ．	疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン
US9737530B1 (en)	2016-06-23	2017-08-22	Collegium Pharmaceutical, Inc.	Process of making stable abuse-deterrent oral formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4264766A (en) *	1877-09-19	1981-04-28	Hoffmann-La Roche Inc.	Immunological diagnostic reagents
US2921883A (en) *	1957-05-03	1960-01-19	Smith Kline French Lab	Novel coating material for medicaments
US3133863A (en) *	1961-03-10	1964-05-19	Strong Cobb Arner Inc	Sustained release therapeutic tablet compositions comprising organic solvent-gelled gums
US3146167A (en) *	1961-10-05	1964-08-25	Smith Kline French Lab	Method of preparing sustained release pellets and products thereof
GB1405088A (en) *	1971-06-03	1975-09-03	Mundipharma Ag	Slow release formulation
US3988482A (en) *	1971-08-27	1976-10-26	Toyo Hakka Kogyo Kabushiki Kaisha	Menthol glycoside, process for preparing the same and method for releasing menthol therefrom
US3818107A (en) *	1972-09-28	1974-06-18	Brook D	Chewing gum with sustained flavor release compositions
US3899439A (en) *	1973-03-12	1975-08-12	Hercules Inc	Method of preparing aqueous dispersions of hydroxypropyl cellulose
DE2644678A1 (de) *	1976-10-02	1978-04-06	Dynamit Nobel Ag	Verfahren zur herstellung funktionalisierter cellulosen
JPS54105223A (en) *	1977-12-29	1979-08-18	Yamanouchi Pharmaceut Co Ltd	Coating agent for solid medicine
US4259355A (en) *	1979-03-05	1981-03-31	International Flavors & Fragrances Inc.	Chewing gum containing flavor composition and flavor composition therefor
US4226849A (en) *	1979-06-14	1980-10-07	Forest Laboratories Inc.	Sustained release therapeutic compositions
US4259314A (en) *	1979-12-10	1981-03-31	Hans Lowey	Method and composition for the preparation of controlled long-acting pharmaceuticals

1979
- 1979-12-19 IE IE2480/79A patent/IE49324B1/en not_active IP Right Cessation
1980
- 1980-07-17 PT PT72214A patent/PT72214B/pt unknown
- 1980-12-08 NZ NZ195793A patent/NZ195793A/xx unknown
- 1980-12-09 IL IL61677A patent/IL61677A/xx not_active IP Right Cessation
- 1980-12-09 GB GB8039449A patent/GB2067569B/en not_active Expired
- 1980-12-09 ZA ZA00807716A patent/ZA807716B/xx unknown
- 1980-12-09 EP EP80304430A patent/EP0032004B1/en not_active Expired
- 1980-12-10 US US06/214,625 patent/US4366310A/en not_active Expired - Lifetime
- 1980-12-10 FI FI803848A patent/FI66623C/fi not_active IP Right Cessation
- 1980-12-10 DK DK527680A patent/DK170347B1/da not_active IP Right Cessation
- 1980-12-11 AU AU65298/80A patent/AU541246B2/en not_active Expired
- 1980-12-15 CA CA000366770A patent/CA1168230A/en not_active Expired
- 1980-12-16 HU HU803005A patent/HU188085B/hu unknown
- 1980-12-17 NO NO803836A patent/NO152846C/no not_active IP Right Cessation
- 1980-12-17 BE BE0/203205A patent/BE886711A/fr not_active IP Right Cessation
- 1980-12-18 PL PL1980228573A patent/PL133079B1/pl unknown
- 1980-12-18 CS CS809008A patent/CS228142B2/cs unknown
- 1980-12-18 SU SU803221253A patent/SU1178326A3/ru active
- 1980-12-18 FR FR8026928A patent/FR2474507B1/fr not_active Expired
- 1980-12-18 NL NLAANVRAGE8006891,A patent/NL187401C/xx not_active IP Right Cessation
- 1980-12-18 JP JP17962980A patent/JPS5698201A/ja active Granted
- 1980-12-18 GR GR63716A patent/GR72265B/el unknown
- 1980-12-18 ES ES497906A patent/ES497906A0/es active Granted
- 1980-12-18 YU YU3210/80A patent/YU40957B/xx unknown
- 1980-12-19 DE DE19803048028 patent/DE3048028A1/de not_active Ceased
- 1980-12-20 EG EG80785A patent/EG14984A/xx active
1981
- 1981-01-05 MX MX185453A patent/MX158088A/es unknown

Also Published As

Publication number	Publication date
ES8303489A1 (es)	1983-02-01
PL133079B1 (en)	1985-05-31
MX158088A (es)	1989-01-06
NZ195793A (en)	1982-09-14
EP0032004A2 (en)	1981-07-15
IE792480L (en)	1981-06-19
IL61677A0 (en)	1981-01-30
PT72214A (en)	1980-08-01
PL228573A1 (no)	1982-07-19
AU6529880A (en)	1981-06-25
JPS5698201A (en)	1981-08-07
FI66623B (fi)	1984-07-31
ES497906A0 (es)	1983-02-01
EP0032004A3 (en)	1982-07-14
DK170347B1 (da)	1995-08-07
GB2067569A (en)	1981-07-30
ZA807716B (en)	1981-12-30
GB2067569B (en)	1983-09-01
DK527680A (da)	1981-08-05
BE886711A (fr)	1981-06-17
US4366310A (en)	1982-12-28
EG14984A (en)	1986-06-30
YU40957B (en)	1986-08-31
GR72265B (no)	1983-10-10
PT72214B (en)	1981-11-02
NO152846B (no)	1985-08-19
YU321080A (en)	1983-06-30
AU541246B2 (en)	1985-01-03
JPH0225921B2 (no)	1990-06-06
FR2474507B1 (fr)	1986-12-26
NO803836L (no)	1981-06-22
NL187401C (nl)	1991-09-16
HUT34891A (en)	1985-05-28
IE49324B1 (en)	1985-09-18
DE3048028A1 (de)	1981-09-10
FR2474507A1 (fr)	1981-07-31
EP0032004B1 (en)	1985-05-15
FI803848L (fi)	1981-06-20
HU188085B (en)	1986-03-28
CA1168230A (en)	1984-05-29
IL61677A (en)	1984-10-31
NL8006891A (nl)	1981-07-16
NO152846C (no)	1985-11-27
NL187401B (nl)	1991-04-16
FI66623C (fi)	1984-11-12
SU1178326A3 (ru)	1985-09-07

Publication	Publication Date	Title
FI66623B (fi)	1984-07-31	Molekylkoordinationskomplex och foerfarande foer dess framstaellning
RU2152802C2 (ru)	2000-07-20	Твердая фармацевтическая композиция и способ ее получения
CA1079638A (en)	1980-06-17	Coated granules of polyacrylic alkali metal salts and method of producing same
JPH06502636A (ja)	1994-03-24	制御放出組成物
JP4213340B2 (ja)	2009-01-21	水性バインダー系調製用凝集体
KR0177493B1 (ko)	1999-03-20	단사정계 결정구조를 갖고 감열, 감광 및 감습성이 있는 활성성분을 함유하는 정제의 제조방법
US4184888A (en)	1980-01-22	Effervescent adhesive-forming product
RU2093500C1 (ru)	1997-10-20	Способ приготовления пороховой массы при изготовлении пироксилиновых порохов
CA1063023A (en)	1979-09-25	Particulate compositions for ointment preparation
Kornblum	1969	Sustained‐action tablets prepared by employing a spray‐drying technique for granulation
DE112006001853T5 (de)	2008-05-15	Pharmazeutische Zusammensetzungen, die Clopidogrel-Bisulphat enthalten
JPH02131434A (ja)	1990-05-21	薬剤組成物
JP2004509943A (ja)	2004-04-02	圧縮２，２−ジブロモ−３−ニトリロプロピオンアミド
CA2259730A1 (en)	2000-07-18	Sustained release tablets containing bupropion hydrochloride
JPH10182448A (ja)	1998-07-07	圧縮製剤用組成物の製造方法
DE60311796T2 (de)	2007-11-22	Methode zur verbesserung der oberflächeneigenschaften von tabletten
RU2823423C1 (ru)	2024-07-23	Способ получения аморфной твердой дисперсии n-бутил-n-метил-1-фенилпирроло[1,2-а]пиразин-3-карбоксамида
JP2000007585A (ja)	2000-01-11	耐湿性固形製剤及びその製造方法
WAN et al.	1986	Action of methylcellulose on disintegration and dissolution properties of tablets
Khandai et al.	2015	Ionotropic cross-linked carbo-protein micro matrix system: an approach for improvement of drug release, compaction and tableting behavior of losartan potassium
CN110448694A (zh)	2019-11-15	一种含抗氧剂的苯磺酸左氨氯地平组合物及其制备方法和应用
JPH04164025A (ja)	1992-06-09	徐放性錠剤の製造方法
CN107961223A (zh)	2018-04-27	一种吉法酯片剂组合物
MXPA01003797A (en)	2001-12-04	HIGH PURITY COMPOSITION COMPRISING (7&agr;,17&agr;)- 17-HYDROXY- 7-METHYL- 19-NOR-17-PREGN- 5(10)-EN-20-YN-3-ONE
FR2836380A1 (fr)	2003-08-29	Procede de fabrication de comprimes de rilmenidine a liberation immediate et comprime obtenu