CU20070261A7 - Compuestos de motilida - Google Patents

Compuestos de motilida

Info

Publication number
CU20070261A7
CU20070261A7 CU20070261A CU20070261A CU20070261A7 CU 20070261 A7 CU20070261 A7 CU 20070261A7 CU 20070261 A CU20070261 A CU 20070261A CU 20070261 A CU20070261 A CU 20070261A CU 20070261 A7 CU20070261 A7 CU 20070261A7
Authority
CU
Cuba
Prior art keywords
compounds
motilida
useful
formula
structure according
Prior art date
Application number
CU20070261A
Other languages
English (en)
Other versions
CU23750B7 (es
Inventor
Mark A Burlingame
Yandong Li
Hao Zheng
Yue Chen
Hong Fu
Simon James Shaw
Yong Li
David C Myles
Christopher Carreras
Yaoquan Lyu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20070261A7 publication Critical patent/CU20070261A7/es
Publication of CU23750B7 publication Critical patent/CU23750B7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

Compuestos que tienen una estructura de acuerdo con la fórmula (I), donde Ra, Rb, Rc, Re y Rf son como se definen en esta invención, son útiles como agentes procinéticos.
CU20070261A 2005-05-24 2007-11-23 Compuestos de motilida CU23750B7 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68461205P 2005-05-24 2005-05-24
US71540605P 2005-09-08 2005-09-08
US74889805P 2005-12-08 2005-12-08
US11/416,519 US7582611B2 (en) 2005-05-24 2006-05-02 Motilide compounds

Publications (2)

Publication Number Publication Date
CU20070261A7 true CU20070261A7 (es) 2009-07-16
CU23750B7 CU23750B7 (es) 2012-01-31

Family

ID=37452327

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20070261A CU23750B7 (es) 2005-05-24 2007-11-23 Compuestos de motilida

Country Status (19)

Country Link
US (1) US7582611B2 (es)
EP (1) EP1888082B1 (es)
JP (1) JP4197359B2 (es)
KR (1) KR100956465B1 (es)
AP (1) AP2337A (es)
AU (1) AU2006249555B2 (es)
BR (1) BRPI0611374A2 (es)
CA (1) CA2609494C (es)
CU (1) CU23750B7 (es)
EA (1) EA014711B1 (es)
ES (1) ES2392860T3 (es)
GE (1) GEP20094854B (es)
IL (1) IL186752A (es)
MA (1) MA29485B1 (es)
MX (1) MX2007014255A (es)
NO (1) NO20076464L (es)
NZ (1) NZ562891A (es)
TN (1) TNSN07436A1 (es)
WO (1) WO2006127252A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0619556A2 (pt) * 2005-12-08 2011-10-04 Pfizer processo para desmetilação de grupo 3' -dimetil amino de compostos eritromicina
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
MX2009005977A (es) 2006-12-05 2009-06-17 Pfizer Polimorfos de motilida.
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
JP5663743B2 (ja) 2009-02-27 2015-02-04 ラクオリア創薬株式会社 モチリン受容体作動活性を有するオキシインドール誘導体
CN102762572A (zh) 2010-02-01 2012-10-31 诺瓦提斯公司 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU35369B (en) 1973-01-19 1980-12-31 Pliva Zagreb Process for preparing n-(benzenesulfonyl)-erythromycilamine derivatives
US3983103A (en) 1973-01-19 1976-09-28 Pliva Pharmaceutical And Chemical Works N-(Benzenesulfonyl)-erythromycylamine derivatives
US3855200A (en) 1973-04-23 1974-12-17 Polska Akademia Nauk Instytut Process for preparing 8-hydroxyerthromycin a and intermediates therefor
YU35363B (en) 1974-01-14 1980-12-31 Pliva Zagreb Process for obtaining n-(benzene-sulfonyl)-5-0desosaminyl-erythromycilamine derivatives
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
IT1196041B (it) 1984-03-08 1988-11-10 Pierrel Spa Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti
JPS60218321A (ja) 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
US5008249A (en) 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
US5175150A (en) 1985-08-31 1992-12-29 Kitasato, Kenkyusho Erythromycin derivative
IL99995A (en) 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DE69211845T2 (de) 1991-04-09 1997-01-23 Abbott Lab Macrozyklische laktam-prokinetika
US5523418A (en) 1991-04-09 1996-06-04 Abbott Laboratories Macrocyclic lactam prokinetic agents
DE4200145A1 (de) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1993013780A1 (en) 1992-01-21 1993-07-22 Abbott Laboratories 4''-deoxyerythromycin derivatives
CA2092045C (en) 1992-03-19 2004-08-10 Setsuo Harada Erythromycin derivatives, preparation and use thereof
MY113693A (en) 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
ZA966601B (en) 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
EP0918783A1 (en) 1996-05-07 1999-06-02 Abbott Laboratories 6-o-substituted erythromycins and method for making them
US5712253A (en) 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B
CA2259420C (en) * 1996-07-05 2007-09-18 Biotica Technology Limited Erythromycins and process for their preparation
HRP960497B1 (en) * 1996-10-28 2003-08-31 Pliva Pharm & Chem Works 9-n-ethenyl derivatives of 9(s)-erythromycylamine
US5922849A (en) 1996-11-22 1999-07-13 Abbott Laboratories Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
WO1999021868A1 (fr) 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
US6084079A (en) 1998-05-15 2000-07-04 Keyes; Robert F. Process for preparing N-demethyl-N-alkyl erythromycin derivatives
KR100317907B1 (ko) * 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
IT1306205B1 (it) * 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
CA2399198A1 (en) 2000-02-18 2001-08-23 Christopher Carreras Motilide compounds
KR100554562B1 (ko) * 2000-09-01 2006-03-03 쥬가이 세이야쿠 가부시키가이샤 에리트로마이신 유도체의 제조 방법
US20020094962A1 (en) 2000-12-01 2002-07-18 Gary Ashley Motilide compounds
JP2002241391A (ja) 2001-02-15 2002-08-28 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
EP1365726A2 (en) 2001-02-15 2003-12-03 Kosan Biosciences, Inc. Method for evaluating therapeutic efficacy
SI1532131T1 (sl) 2002-08-29 2009-04-30 Pfizer Motilidne spojine
US7407941B2 (en) 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
US7211568B2 (en) 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US20060075011A1 (en) * 2004-09-23 2006-04-06 Fujitsu Limited System and method for optimizing polynomial expressions in a processing environment
TW200633714A (en) 2004-12-28 2006-10-01 Chugai Pharmaceutical Co Ltd Drugs for the treatment and/or prophylaxis of gastroparesis symptom

Also Published As

Publication number Publication date
NZ562891A (en) 2011-01-28
MX2007014255A (es) 2008-01-22
CA2609494A1 (en) 2006-11-30
TNSN07436A1 (fr) 2009-03-17
AU2006249555A8 (en) 2006-11-30
EA200702290A1 (ru) 2008-04-28
HK1117739A1 (en) 2009-01-23
US7582611B2 (en) 2009-09-01
WO2006127252A1 (en) 2006-11-30
AP2007004220A0 (en) 2007-10-31
IL186752A0 (en) 2008-02-09
MA29485B1 (fr) 2008-05-02
EP1888082A4 (en) 2008-12-17
AU2006249555B2 (en) 2009-07-16
AU2006249555A1 (en) 2006-11-30
ES2392860T3 (es) 2012-12-14
NO20076464L (no) 2008-02-22
AP2337A (en) 2011-12-14
CA2609494C (en) 2010-12-21
BRPI0611374A2 (pt) 2010-08-31
GEP20094854B (en) 2009-12-10
KR20080013922A (ko) 2008-02-13
EA014711B1 (ru) 2011-02-28
US20060270616A1 (en) 2006-11-30
CU23750B7 (es) 2012-01-31
JP4197359B2 (ja) 2008-12-17
EP1888082B1 (en) 2012-09-12
JP2008542268A (ja) 2008-11-27
KR100956465B1 (ko) 2010-05-07
EP1888082A1 (en) 2008-02-20
IL186752A (en) 2011-10-31

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Legal Events

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FG Grant of patent
FD Lapse (for not paying fees)