CU20090064A7 - Nuevos derivados de benzamida como antagonistas de la bradiquinina - Google Patents

Nuevos derivados de benzamida como antagonistas de la bradiquinina

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Publication number
CU20090064A7
CU20090064A7 CU2009000064A CU20090064A CU20090064A7 CU 20090064 A7 CU20090064 A7 CU 20090064A7 CU 2009000064 A CU2009000064 A CU 2009000064A CU 20090064 A CU20090064 A CU 20090064A CU 20090064 A7 CU20090064 A7 CU 20090064A7
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CU
Cuba
Prior art keywords
antagonists
bradiquinina
benzamida
new derivatives
formula
Prior art date
Application number
CU2009000064A
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English (en)
Other versions
CU23857B1 (es
Inventor
Monika Vastag
Eva Szentirmay
Katalin Hornok
Gyula Beke
Eva Schmidt
Gyoergy Keseru
Istvan Vago
BOZO Eva KOVACSNE
Sandor Farkas
Original Assignee
Richter Gedeon Vegyseszeti Gyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyseszeti Gyar Rt filed Critical Richter Gedeon Vegyseszeti Gyar Rt
Publication of CU20090064A7 publication Critical patent/CU20090064A7/es
Publication of CU23857B1 publication Critical patent/CU23857B1/es

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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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Abstract

La presente inven ción se refiere a nuevos derivados de fenilsulfamoilbenzamida de fórmula (I) ESPACIO PARA FÓRMULA en la cual R1-R5 y Z son como se definen en las reivindicaciones, y los antípodas ópticos o racematos y/o sales y/o hidratos y/o solvatos de los mismos, los cuales son antagonistas selectivos de la bradiquinina B1, aprocesos para producir estos mismos compuestos, a las composiciones farmacológicas que los contienen y a su uso en la terapia o prevención de estados dolorosos e inflamatorios.
CU20090064A 2006-10-27 2009-04-22 Nuevos derivados de benzamida como antagonistas de la bradiquinina CU23857B1 (es)

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HU0600808A HUP0600808A3 (en) 2006-10-27 2006-10-27 New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
PCT/HU2007/000102 WO2008068540A1 (en) 2006-10-27 2007-10-27 New benzamide derivatives as bradykinin antagonists

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP1000312A3 (en) * 2007-10-27 2011-03-28 Richter Gedeon Nyrt New non peptide derivatives as bradykinin bl antagonists
CN102159077A (zh) * 2008-08-21 2011-08-17 吉瑞工厂 用于治疗神经性疼痛的方法
US20100048630A1 (en) * 2008-08-21 2010-02-25 Pradeep Banerjee Methods for treating cns disorders
PT2401256E (pt) * 2009-02-26 2013-05-13 Boehringer Ingelheim Int Compostos como antagonistas da bradicinina b1
ES2350077B1 (es) * 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
CN107205972A (zh) * 2014-04-23 2017-09-26 X-Rx股份有限公司 自分泌运动因子的取代的n‑(2‑(氨基)‑2‑氧代乙基)苯甲酰胺抑制剂及它们的制备和在治疗lpa‑依赖的或lpa‑介导的疾病中的用途
KR101676850B1 (ko) 2015-04-23 2016-11-18 한일화섬 주식회사 내구성이 우수한 스피커용 댐퍼 및 그 제조 방법
TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
US12649738B2 (en) 2020-03-26 2026-06-09 Richter Gedeon Nyrt. 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine derivatives as GABAA α5 receptor modulators
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1279843A (en) 1969-05-23 1972-06-28 Science Union & Cie Benzamidoethyl-piperazines and process for their preparation
US5714497A (en) 1993-02-15 1998-02-03 Sanofi Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
GB9804885D0 (en) 1998-03-06 1998-04-29 Merck Sharp & Dohme Therapeutic combination
GB9913079D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US6017961A (en) 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
AU2001268607A1 (en) 2000-06-21 2002-01-02 Bristol-Myers Squibb Company Piperidine amides as modulators of chemokine receptor activity
FR2822827B1 (fr) 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
WO2002099388A2 (en) 2001-06-07 2002-12-12 Merck & Co., Inc. Benzodiazepine bradykinin antagonists
KR100890676B1 (ko) 2001-07-24 2009-03-26 리히데 게데온 베기에스제티 기아르 알티 신규한 카르복시산 아미드 화합물
AU2003228825A1 (en) 2002-05-03 2003-11-17 Elan Pharmaceuticals, Inc. Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists
US6908921B2 (en) 2002-12-13 2005-06-21 Merck & Co., Inc. Quinoxalinone derivatives as bradykinin B1 antagonists
WO2005004810A2 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Arylsulfonamide derivatives
CA2544981A1 (en) 2003-11-12 2005-05-26 Merck & Co., Inc. 4-phenyl piperidine sulfonyl glycine transporter inhibitors
HU230518B1 (hu) 2005-12-20 2016-10-28 Richter Gedeon Nyrt. Bradykinin B1 receptor szelektív antagonista hatással rendelkező új fenatridin származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények
HUP0600810A3 (en) 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600809A3 (en) 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP1000312A3 (en) 2007-10-27 2011-03-28 Richter Gedeon Nyrt New non peptide derivatives as bradykinin bl antagonists
CN102037355A (zh) 2008-03-04 2011-04-27 里奇诊断学股份有限公司 基于多重生物标记物板块诊断和监测抑郁症
US20100048630A1 (en) 2008-08-21 2010-02-25 Pradeep Banerjee Methods for treating cns disorders
CN102159077A (zh) 2008-08-21 2011-08-17 吉瑞工厂 用于治疗神经性疼痛的方法
WO2011094308A2 (en) 2010-01-26 2011-08-04 Ridge Diagnostics, Inc. Multiple biomarker panels to stratify disease severity and monitor treatment of depression

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